Tag: Activator

For research use only. We do not sell to patients. CIL56 CAS No. : 300802-28-2 Biological Activity：CIL56 is a potent and selective ferroptosis inducer. Ferroptosis is an iron-dependent form of regulated cell death (RCD). Research Area：Cancer Targets：Ferroptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Anti-Cancer Compound Library;Oxygen Sensing Compound Library;Ferroptosis Compound Library; Related Small Molecules:DB0614;Ciclopirox-d11;Ciclopirox […]

For research use only. We do not sell to patients. Cinaciguat hydrochloride CAS No. : 646995-35-9 Biological Activity：Cinaciguat hydrochloride is a potent soluble guanylate cyclase (GC) activator with EC50 of 15 nM in platelets. Research Area：Cardiovascular Disease Targets：Guanylate Cyclase Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Clinical […]

For research use only. We do not sell to patients. AMPK activator 4 CAS No. : 2493239-46-4 Biological Activity：AMPK activator 4 is a potent AMPK activator without inhibition of mitochondrial complex I. AMPK activator 4 selectively activates AMPK in the muscle tissues. AMPK activator 4 dose-dependently improves glucose tolerance in normal mice, and significantly lowers […]

For research use only. We do not sell to patients. Pinoresinol dimethyl ether CAS No. : 29106-36-3 Biological Activity：Pinoresinol dimethyl ether ((+)-Eudesmin) is a non-phenolic furofuran lignan isolated from Magnolia biondii with neuritogenic activity. Pinoresinol dimethyl ether ((+)-Eudesmin) can induce neuritis outgrowth from PC12 cells by stimulating up-stream MAPK, PKC and PKA pathways[2]. Research Area：Neurological […]

For research use only. We do not sell to patients. Notoginsenoside Fc CAS No. : 88122-52-5 Biological Activity：Notoginsenoside Fc, a protopanaxadiol- (PPD-) type saponin isolated from the leaves of Panax notoginseng, effectively counteracts platelet aggregation. Notoginsenoside Fc can accelerate reendothelialization following vascular injury in diabetic rats by promoting autophagy. Research Area：Cardiovascular Disease Targets：Autophagy Related Screening […]

For research use only. We do not sell to patients. Lu AE98134 CAS No. : 849000-18-6 Biological Activity：Lu AE98134, an activator of voltage-gated sodium channels, acts as a partly selective Nav1.1 channels positive modulator. Lu AE98134 also increases the activity of Nav1.2 and Nav1.5 channels but not of Nav1.4, Nav1.6 and Nav1.7 channels. Lu AE98134 […]

For research use only. We do not sell to patients. Ecteinascidin 770 CAS No. : 114899-80-8 Biological Activity：Ecteinascidin 770 (ET-770) is a 1,2,3,4-tetrahydroisoquinoline alkaloid with potent anti-cancer activities; inhibits U373MG cells with an IC50 of 4.83 nM. Research Area：Cancer Targets：Apoptosis Related Screening Libraries:Natural Product Library Plus;Bioactive Compound Library Plus; Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;BJE6-106;Dinaciclib;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase […]

For research use only. We do not sell to patients. Compound 48/80 CAS No. : 94724-12-6 Biological Activity：Compound 48/80 (Poly-p-methoxyphenethylmethylamine) is widely used in animal and tissue models as a “selective” mast cell activator. Compound 48/80 acts at the mast cell membrane to stimulate trimeric G-proteins and induces degranulation via phospholipase C and D pathways[2]. […]

For research use only. We do not sell to patients. PG01 CAS No. : 853138-65-5 Biological Activity：PG01 is a potent CFTR Cl– channel potentiator. PG01 can correct gating defects of CFTR mutants, is effective on b>E193K, G970R and G551D (CFTR mutants) with Kd values of 0.22 μM, 0.45 μM and 1.94 μM, respectively. PG01 is […]

For research use only. We do not sell to patients. CIQ CAS No. : 486427-17-2 Biological Activity：CIQ is a subunit-selective potentiator of NMDA receptors containing the NR2C or NR2D subunit. Research Area：Neurological Disease Targets：iGluR Related Screening Libraries:Bioactive Compound Library Plus;Membrane Transporter/Ion Channel Compound Library;Neuronal Signaling Compound Library;Neurotransmitter Receptor Compound Library; Related Small Molecules:Quinolinic acid-d3;1-Aminocyclobutanecarboxylic acid;Glycine-1-13C,15N;ZL006;PYD-106;NMDA-IN-2;JAMI1001A;(S)-Willardiine;Fanapanel;(S)-AMPA;L-Glutamic […]