Tag: Agonist|Activator

For research use only. We do not sell to patients. Bexarotene D4 CAS No. : 2182068-00-2 Biological Activity：Bexarotene D4 is a deuterium labeled Bexarotene (LGD1069). Bexarotene (LGD1069) is a selective retinoid X receptors (RXR) agonist for the treatment of cutaneous T-cell lymphoma[2][3][4][5]. Research Area：Cancer Targets：Autophagy|RAR/RXR Related Small Molecules:AGN 193109-d7;Retinoic acid;AC-261066;Magnolol;ER 50891;(+)-Talarozole;Trifarotene;β-Apo-13-carotenone;Bigelovin;CD2665;BMS453;9-cis-Retinoic acid;AGN-195183;Fenretinide;Liarozole dihydrochloride;BMS-195614;LE135;Tamibarotene;UVI 3003;PROTAC RAR […]

For research use only. We do not sell to patients. Cinnabarinic acid CAS No. : 606-59-7 Biological Activity：Cinnabarinic acid is a specific orthosteric agonist of mGlu4 by interacting with residues of the glutamate binding pocket of mGlu4, has no activity at other mGlu receptors. Cinnabarinic acid is an endogenous metabolite of the kynurenine pathway of […]

For research use only. We do not sell to patients. 7,8-Dihydroxyflavone CAS No. : 38183-03-8 Biological Activity：7,8-Dihydroxyflavone is a potent and selective TrkB agonist that mimics the physiological actions of Brain-derived neurotrophic factor (BDNF). Displays therapeutic efficacy toward various neurological diseases. Research Area：Neurological Disease Targets：Trk Receptor|Apoptosis Related Screening Libraries:Natural Product Library Plus;Bioactive Compound Library Plus;Apoptosis […]

For research use only. We do not sell to patients. Dabuzalgron CAS No. : 219311-44-1 Biological Activity：Dabuzalgron (Ro 115-1240) is an orally active and selective α-1A adrenergic receptor agonist for the treatment of urinary incontinence. Dabuzalgron protects against Doxorubicin-induced cardiotoxicity by preserving mitochondrial function. Research Area：Endocrinology|Cardiovascular Disease Targets：Adrenergic Receptor|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis […]

For research use only. We do not sell to patients. ZSET1446 CAS No. : 887603-94-3 Biological Activity：ZSET1446 is a novel cognitive enhancer that significantly improves learning deficits in various types of Alzheimer disease (AD) models. Research Area：Neurological Disease|Cancer Targets：nAChR|Calcium Channel Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Membrane Transporter/Ion Channel […]

For research use only. We do not sell to patients. Yoda 1 CAS No. : 448947-81-7 Biological Activity：Yoda 1 is a potent and selective Piezo1 agonist. Yoda 1 activates purified Piezo1 channels. Yoda 1 potently inhibits macropinocytosis induced by epidermal growth factor (EGF). Yoda 1 enhances Ca2+ influx followed by activation of the calcium-activated potassium […]

For research use only. We do not sell to patients. Inecalcitol CAS No. : 163217-09-2 Biological Activity：Inecalcitol (TX 522), a unique vitamin D3 analog, is an orally active vitamin D receptor (VDR) agonist with a Kd of 0.53 nM. Inecalcitol can induce cell apoptosis and has potent anticancer activities[2][3][4]. Research Area：Cancer Targets：VD/VDR|Apoptosis Related Screening Libraries:Drug […]

For research use only. We do not sell to patients. PI3K/Akt/CREB activator 1 CAS No. : 2708177-73-3 Biological Activity：PI3K/Akt/CREB activator 1 (compound AE-18) is a potent, orally active PI3K/Akt/CREB activator. PI3K/Akt/CREB activator 1 promotes neuronal proliferation, induced differentiation of Neuro-2a cells into a neuron-like morphology, and accelerated the establishment of axon-dendrite polarization of primary hippocampal […]

For research use only. We do not sell to patients. CHPG CAS No. : 170846-74-9 Biological Activity：CHPG is a selective mGluR5 agonist, and attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells. CHPG protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt […]

For research use only. We do not sell to patients. Siramesine hydrochloride CAS No. : 224177-60-0 Biological Activity：Siramesine (Lu 28-179) hydrochloride is a potent sigma-2 receptor agonist. Siramesine hydrochloride has a subnanomolar affinity for sigma-2 receptors (IC50=0.12 nM) and exhibits a 140-fold selectivity for sigma-2 receptors over sigma-1 receptors (IC50=17 nM). Siramesine hydrochloride triggers cell death through […]