Tag: Activator|Inhibitor

For research use only. We do not sell to patients. D-α-Hydroxyglutaric acid disodium CAS No. : 103404-90-6 Biological Activity：D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid disodium is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a Ki of 10.87 mM. […]

For research use only. We do not sell to patients. Calpeptin CAS No. : 117591-20-5 Biological Activity：Calpeptin is a potent, cell penetrating calpain inhibitor, with an ID50 of 40 nM for Calpain I in human platelets. Calpeptin is also an inhibitor of cathepsin K[2]. Research Area：Inflammation/Immunology Targets：Cathepsin|Proteasome|Apoptosis Related Screening Libraries:Covalent Screening Library Plus;Bioactive Compound Library […]

For research use only. We do not sell to patients. BJE6-106 CAS No. : 1564249-38-2 Biological Activity：BJE6-106 (B106) is a potent, selective 3rd generation PKCδ inhibitor with an IC50 of 0.05 μM and targets selectivity over classical PKC isozyme PKCα (IC50=50 μM). BJE6-106 (B106) induces caspase-dependent apoptosis. BJE6-106 (B106) possesses tumor-specific effect. Research Area：Cancer|Inflammation/Immunology Targets：PKC|Apoptosis […]

For research use only. We do not sell to patients. SNS-032 CAS No. : 345627-80-7 Biological Activity：SNS-032 (BMS-387032) is a potent and selective inhibitor of CDK2, CDK7, and CDK9 with IC50s of 38 nM, 62 nM and 4 nM, respectively. SNS-032 has antitumor effect. Research Area：Cancer Targets：CDK|Apoptosis Related Screening Libraries:Clinical Compound Library Plus;Bioactive Compound Library Plus;Apoptosis Compound Library;Cell […]

For research use only. We do not sell to patients. MitoTam bromide, hydrobromide CAS No. : 1634624-73-9 Biological Activity：MitoTam bromide, hydrobromide, a Tamoxifen derivative, is an electron transport chain (ETC) inhibitor. MitoTam bromide, hydrobromide reduces mitochondrial membrane potential in senescent cells and affects mitochondrial morphology[2]. MitoTam bromide, hydrobromide is an effective anticancer agent, suppresses respiratory […]

For research use only. We do not sell to patients. Apremilast CAS No. : 608141-41-9 Biological Activity：Apremilast (CC-10004) is an orally available inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4) with an IC50 of 74 nM. Apremilast inhibits TNF-α release by lipopolysaccharide (LPS) with an IC50 of 104 nM. Research Area：Inflammation/Immunology Targets：Phosphodiesterase (PDE)|TNF Receptor|Apoptosis Related Screening […]

For research use only. We do not sell to patients. WYE-354 CAS No. : 1062169-56-5 Biological Activity：WYE-354 is an ATP-competitive mTOR inhibitor with an IC50 of 5 nM. WYE-354 also inhibits PI3Kα and PI3Kγ with IC50s of 1.89 μM and 7.37 μM, respectively. WYE-354 inhibits both mTORC1 and mTORC2. WYE-354 induces autophagy activation in vitro[3]. […]

For research use only. We do not sell to patients. Sennidin A CAS No. : 641-12-3 Biological Activity：Sennidin A, isolated from the leaves of Cassia angustifolia, inhibits HCV NS3 helicase, with an IC50 of 0.8 μM. Sennidin A induces phosphorylation of Akt and glucose transporter 4 (GLUT4) translocation. Sennidin A stimulates the glucose incorporation[2]. Research […]

For research use only. We do not sell to patients. DBeQ CAS No. : 177355-84-9 Biological Activity：DBeQ is a selective, potent, reversible, and ATP-competitive p97 inhibitor, with an IC50 value of 1.5 μM and 1.6 μM for p97(wt) and p97(C522A), respectively; DBeQ also inhibits Vps4 with an IC50 of 11.5 μM. Research Area：Cancer Targets：Autophagy|Apoptosis|p97 Related […]

For research use only. We do not sell to patients. Articaine CAS No. : 23964-58-1 Biological Activity：Articaine (Hoe-045 free base) is an amide anaesthetic containing an ester group, reversibly binding to the α-subunit of the voltage-gated sodium channels within the inner cavity of the nerve, can provide effective pain relief. Articaine ameliorates LPS-induced acute kidney […]