Tag: Antagonist|Inducer

For research use only. We do not sell to patients. ENMD-1068 hydrochloride Biological Activity：ENMD-1068 hydrochloride is a selective protease-activated receptor 2 (PAR2) antagonist. ENMD-1068 hydrochloride reduces hepatic stellate cell activation and collagen expression by inhibiting TGF-β1/Smad signaling. ENMD-1068 hydrochloride also inhibits the proliferation of endometrial cells and induces apoptosis of epithelial cells in the lesion. […]

For research use only. We do not sell to patients. Raloxifene hydrochloride CAS No. : 82640-04-8 Biological Activity：Raloxifene hydrochloride (Keoxifene hydrochloride) is a second generation selective and orally active estrogen receptor modulator. Raloxifene hydrochloride produces estrogen-agonistic effects on bone and lipid metabolism and estrogen-antagonistic effects on uterine endometrium and breast tissue. Research Area：Endocrinology|Cancer Targets：Autophagy|Estrogen Receptor/ERR Related […]

For research use only. We do not sell to patients. APG-1387 CAS No. : 1570231-89-8 Biological Activity：APG-1387, a bivalent SMAC mimetic and an IAP antagonist, blocks the activity of IAPs family proteins (XIAP, cIAP-1, cIAP-2, and ML-IAP). APG-1387 induces degradation of cIAP-1 and XIAP proteins, as well as caspase-3 activation and PARP cleavage, which leads […]

For research use only. We do not sell to patients. Tolvaptan-D7 CAS No. : 1246818-18-7 Biological Activity：Tolvaptan-D7 (OPC-41061-D7) is the deuterium labeled Tolvaptan. Tolvaptan is a selective, competitive arginine vasopressin receptor 2 antagonist with an IC50 of 1.28μM for the inhibition of AVP-induced platelet aggregation[2]. Research Area：Cardiovascular Disease|Endocrinology|Cancer Targets：Autophagy|Vasopressin Receptor Related Small Molecules:Lixivaptan;Mozavaptan hydrochloride;Balovaptan;Big Endothelin-1 […]

For research use only. We do not sell to patients. Rupatadine Fumarate CAS No. : 182349-12-8 Biological Activity：Rupatadine (UR-12592) Fumarate is a potent, orally active and long-lasting dual PAF/H1 antagonist, with Kis of 0.55 μM and 0.1 μM, respectively. Rupatadine Fumarate can be used for the research of allergic rhinitis and urticaria[2][3]. Research Area：Inflammation/Immunology Targets：Autophagy|Histamine […]

For research use only. We do not sell to patients. Telmisartan-d3 CAS No. : 1189889-44-8 Biological Activity：Telmisartan-d3 is the deuterium labeled Telmisartan. Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM[2]. Research Area：Cardiovascular Disease|Endocrinology Targets：Autophagy|Angiotensin Receptor […]

For research use only. We do not sell to patients. Deutenzalutamide CAS No. : 1443331-82-5 Biological Activity：Deutenzalutamide (Enzalutamide-d3) is a deuterium labeled Enzalutamide (MDV3100). Enzalutamide is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells. Research Area：Cancer Targets：Androgen Receptor|Autophagy Related Small Molecules:VPC-14449;AC-262536;GTx-007;Linuron-d6;MI-136;VPC-13789;RD162;ARD-2585;PF-998425;GSK-2881078;PROTAC AR Degrader-4;RU 58841;Triptophenolide;ARD-61;Dehydroisoandrosterone 3-acetate;Topilutamide;CSRM617 hydrochloride;ARD-2128;A4B17;MK-0773;LH-RH II (chicken) […]

For research use only. We do not sell to patients. Bcl-xL antagonist 2 CAS No. : 1235032-75-3 Biological Activity：Bcl-xL antagonist 2 is a potent, selective, and orally active antagonist of BCL-XL with an IC50 and Ki of 0.091 μM and 65 nM, respectively. Bcl-xL antagonist 2 promotes the apoptosis of cancer cells. Bcl-xL antagonist 2 […]

For research use only. We do not sell to patients. Irbesartan-d6 Biological Activity：Irbesartan-d6 is the deuterium labeled Irbesartan. Irbesartan is a highly potent and specific angiotensin II type 1 (AT1) receptor antagonist with IC50 of 1.3 nM. Research Area：Cardiovascular Disease|Endocrinology Targets：Angiotensin Receptor|Apoptosis Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;Xevinapant;Mangiferin;Cambinol;Antioxidant agent-5;Apoptosis inducer 9;Bafetinib;Cyclovirobuxine […]

For research use only. We do not sell to patients. Prazosin hydrochloride CAS No. : 19237-84-4 Biological Activity：Prazosin hydrochloride is a well-tolerated, CNS-active α1-adrenergic receptor antagonist for the research of high blood pressure and alcohol use disorders. Prazosin hydrochloride potently inhibits Norepinephrine (NE)-stimulated 45Ca efflux with an IC50 of 0.15 nM[2].Prazosin hydrochloride inhibits organic cation […]