Tag: Activator|Inducer|Inhibitor

For research use only. We do not sell to patients. Lapatinib ditosylate CAS No. : 388082-77-7 Biological Activity：Lapatinib ditosylate (GW572016 ditosylate) is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively. Research Area：Cancer Targets：EGFR|Ferroptosis|Autophagy Related Screening Libraries:Drug Repurposing Compound […]

For research use only. We do not sell to patients. TD52 dihydrochloride Biological Activity：TD52 dihydrochloride, an Erlotinib (HY-50896) derivative, is an orally active, potent cancerous inhibitor of protein phosphatase 2A (CIP2A) inhibitor. TD52 dihydrochloride mediates the apoptotic effect in triple-negative breast cancer (TNBC) cells via regulating the CIP2A/PP2A/p-Akt signalling pathway. TD52 dihydrochloride indirectly reduced CIP2A […]

For research use only. We do not sell to patients. Olaparib CAS No. : 763113-22-0 Biological Activity：Olaparib (AZD2281; KU0059436) is a potent and orally active PARP inhibitor with IC50s of 5 and 1 nM for PARP1 and PARP2, respectively. Olaparib is an autophagy and mitophagy activator[2][3][4]. Research Area：Cancer Targets：PARP|Autophagy|Mitophagy Related Screening Libraries:Drug Repurposing Compound Library […]

For research use only. We do not sell to patients. Gallic acid hydrate CAS No. : 5995-86-8 Biological Activity：Gallic acid (3,4,5-Trihydroxybenzoic acid) hydrate is a natural polyhydroxyphenolic compound and an free radical scavenger to inhibit cyclooxygenase-2 (COX-2). Gallic acid hydrate has various activities, such as antimicrobial, antioxidant, antimicrobial, anti-inflammatory, and anticance activities[2]. Research Area：Cancer|Inflammation/Immunology Targets：Ferroptosis|Reactive […]

For research use only. We do not sell to patients. Gallic acid CAS No. : 149-91-7 Biological Activity：Gallic acid (3,4,5-Trihydroxybenzoic acid) is a natural polyhydroxyphenolic compound and an free radical scavenger to inhibit cyclooxygenase-2 (COX-2). Gallic acid has various activities, such as antimicrobial, antioxidant, antimicrobial, anti-inflammatory, and anticance activities[2]. Research Area：Cancer|Metabolic Disease Targets：Ferroptosis|Reactive Oxygen Species|Endogenous […]

For research use only. We do not sell to patients. Carbamazepine-d8 CAS No. : 1538624-35-9 Biological Activity：Carbamazepine-d8 is the deuterium labeled Carbamazepine. Carbamazepine, a sodium channel blocker, is an anticonvulsant drug, with an IC50 of 131 μM[2]. Research Area：Cancer|Neurological Disease Targets：Autophagy|Sodium Channel|Mitophagy Related Small Molecules:Lu AE98134;Zandatrigine;Curcumin;Veratridine;Melatonin-d3;Brompheniramine-d6 maleate;GX-674;Dibucaine;Sodium Channel inhibitor 2;3-Deoxyaconitine;20(S)-Ginsenoside Rg3;Resveratrol;Clioquinol;Tocainide hydrochloride;Licarbazepine-d4-1;Metaflumizone-d4;β-Pompilidotoxin;Nav1.1 activator 1;ICA-121431;Brompheniramine maleate;ABBV-318 […]

For research use only. We do not sell to patients. Pregnenolone CAS No. : 145-13-1 Biological Activity：Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. […]

For research use only. We do not sell to patients. RSVA405 CAS No. : 140405-36-3 Biological Activity：RSVA405 is a potent, orally active activator of AMPK, with an EC50 of 1 μM. RSVA405 facilitates CaMKKβ-dependent activation of AMPK, inhibits mTOR, and promotes autophagy to increase Aβ degradation. RSVA405 has anti-inflammatory effects through the inhibition of STAT3 […]

For research use only. We do not sell to patients. Lapatinib-d7 dihydrochloride Biological Activity：Lapatinib-d7 (GW572016-d7) dihydrochloride is the deuterium labeled Lapatinib dihydrochloride. Lapatinib (GW572016) dihydrochloride is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively. Research Area：Cancer Targets：EGFR|Ferroptosis|Autophagy Related […]

For research use only. We do not sell to patients. Pitavastatin-d5 sodium Biological Activity：Pitavastatin-d5 sodium (NK-104-d5 sodium) is the deuterium labeled Pitavastatin sodium. Pitavastatin (NK-104) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells. Pitavastatin is an efficient hepatocyte low-density lipoprotein-cholesterol […]