March 2025
IGF-I/IGF-1 Protein, Human (70a.a)
Description IGF-I/IGF-1 Protein, Human (70a.a) is a mitogenic cytokine, binds to IGF type 1 receptor, and modulates growth in many tissues, such as nervous tissue, lymphoid tissue, reproductive tissue, smooth muscle, endothelium, and bone; IGF-I/IGF-1 Protein also mediates neuroprotective mechanism. Background Insulin-like growth factor (IGF) system has been shown to modulate growth in many tissues, such […]
Nobel Prizes 2024：Three major awards announced
The Nobel Prize in Physiology or Medicine 2024 Discovery of micrornas and their role in post-transcriptional gene regulation On October 7, the Karolinska Institute in Sweden announced that the 2024 Nobel Prize in Physiology or Medicine will be awarded to American scientists Victor Ambros and Gary Ruvkun for their discovery of microRNA (miRNA) and its […]
How they used PKH 26 for cellular studies?
With the increasing trend of global aging, sarcopenia has become a significant public health issue. Sarcopenia, a loss of skeletal muscle mass and function associated with aging, is a progressive and widespread skeletal muscle disease. Goji berry, also known as “Gou qi zi” in China, is a traditional Chinese herb that can enhance the structure […]
Mitochondrial Quality Control: Mechanisms of Biogenesis, Dynamics, and Degradation
Mitochondrial biogenesis Mitochondrial quality control (MQC) is a comprehensive network that monitors mitochondrial quality and serves as an endogenous protective program, which is crucial for maintaining mitochondrial homeostasis and function[1]. MQC coordinates various processes, such as biogenesis, mitochondrial fission, fusion, mitochondrial protein degradation, and mitophagy, to collectively regulate and maintain mitochondrial homeostasis[2]. Typically, after a […]
PANoptosis: A Novel Inflammatory PCD Pathway !
Inflammatory PCD Pathway: PANoptosis PANoptosis is an inflammatory PCD pathway activated by specific triggers and regulated by the PANoptosome complex, which integrates key features of pyroptosis, apoptosis, and/or necroptosis. This is also the source of the “P,” “A,” and “N” in the term PANoptosis, but it cannot be solely represented by any one of these […]
National Natural Science Foundation Hotspot! What is Autophagy?
Autophagy Autophagy is a fundamental process that degrades various components within the cell. Autophagy can be non-selective, where cytoplasmic materials are sequestered into autophagosomes for engulfment, typically occurring during nutrient deprivation. In contrast, selective autophagy degrades specific targets, such as damaged organelles: mitophagy, lysophagy, and ER-phagy, playing a crucial role in cellular quality control (Fig. […]
Can the 16:8 Intermittent Fasting Method Help You Lose Weight ?
1. The Science Behind [16+8]: Intermittent Fasting First, the conclusion: It is feasible! The 16+8 weight loss method involves eating all three meals within an 8-hour window, followed by 16 hours of only water consumption, with no food intake. As early as 2022, Humaira Jamshed and colleagues published a randomized clinical trial in JAMA Internal […]
An Immune-Based Memory Mechanism: The Memory Circuit “Created” by TLR9 Inflammatory Signals and DNA Damage!
1. “Brain Inflammation” and DNA Damage: The Surprising Keys to Long-Term Memory When you hear “inflammation” and “DNA damage,” you might immediately think of disease or injury. However, in brains, these two processes are key steps in forming long-term memories, particularly related to specialized cells in our brain called hippocampal neurons. These neurons act like […]