Tag: p53 Activator

For research use only. We do not sell to patients. NSC59984 CAS No. : 803647-40-7 Biological Activity：NSC59984 induces mutant p53 protein degradation via MDM2 and the ubiquitin-proteasome pathway. NSC59984 acts by targeting GOF-mutant p53 and stimulates p73 to restore the p53 pathway signaling[2]. Research Area：Cancer Targets：MDM-2/p53 Related Screening Libraries:Covalent Screening Library Plus;Bioactive Compound Library Plus;Apoptosis […]

For research use only. We do not sell to patients. PhiKan 083 CAS No. : 880813-36-5 Biological Activity：PhiKan 083 is a carbazole derivative, which binds to the surface cavity and stabilizes Y220C (a p53 mutant), with a Kd of 167 μM. PhiKan 083 can be used for cancer research. Research Area：Cancer Targets：MDM-2/p53 Related Screening Libraries:Bioactive […]

For research use only. We do not sell to patients. NSC319726 CAS No. : 71555-25-4 Biological Activity：NSC319726 (ZMC1) is a mutant p53R175 reactivator; inhibits growth of fibroblasts expressing the p53R175 mutation (IC50 = 8 nM); shows no inhibition for p53 wild-type cells. Research Area：Cancer Targets：MDM-2/p53 Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Anti-Cancer Compound Library;Autophagy […]

For research use only. We do not sell to patients. Amifostine thiol dihydrochloride CAS No. : 14653-77-1 Biological Activity：Amifostine thiol (WR-1065) dihydrochloride can protect normal tissues from the toxic effects of certain cancer drugs and activate p53 through a JNK-dependent signaling pathway. Research Area：Cancer Targets：MDM-2/p53 Related Screening Libraries:Covalent Screening Library Plus;Bioactive Compound Library Plus;Apoptosis Compound […]

For research use only. We do not sell to patients. PK11000 CAS No. : 38275-34-2 Biological Activity：PK11000 is an alkylating agent, and stabilizes the DNA-binding domain of both WT and mutant p53 proteins by covalent cysteine modification without compromising DNA binding. PK11000 has anti-tumor activities. Research Area：Cancer Targets：DNA Alkylator/Crosslinker|MDM-2/p53 Related Screening Libraries:Covalent Screening Library Plus;Bioactive […]

For research use only. We do not sell to patients. CP-31398 dihydrochloride CAS No. : 1217195-61-3 Biological Activity：CP-31398 dihydrochloride stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53[2][3]. Research Area：Cancer Targets：MDM-2/p53 Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Anti-Cancer Compound Library;Autophagy Compound Library;Anti-Aging Compound Library;Ferroptosis […]

For research use only. We do not sell to patients. PhiKan 083 hydrochloride CAS No. : 1050480-30-2 Biological Activity：PhiKan 083 hydrochloride is a carbazole derivative, which binds to the surface cavity and stabilizes Y220C (a p53 mutant), with a Kd of 167 μM, and a relative binding affinity (Kd) of 150 μM in Ln229 cells[3]. […]

For research use only. We do not sell to patients. Kevetrin hydrochloride-13C2,15N3 CAS No. : 2300178-72-5 Biological Activity：Kevetrin hydrochloride-13C2,15N3 is the 13C-labeled and 15N-labeled Kevetrin (hydrochloride). Kevetrin hydrochloride is a small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity. Research Area：Cancer Targets：MDM-2/p53 Related Small Molecules:MDM2-p53-IN-15;MC-VC-PABC-SP 141;p53 and MDM2 proteins-interaction-inhibitor (racemic);Navtemadlin;MD-224;Mutant […]

For research use only. We do not sell to patients. NSC-207895 CAS No. : 58131-57-0 Biological Activity：NSC-207895 (XI-006), a DNA damaging agent, is an anticancer agent and p53 activator[2][3]. Research Area：Cancer Targets：MDM-2/p53 Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Anti-Cancer Compound Library;Autophagy Compound Library;Anti-Aging Compound Library;Ferroptosis Compound Library;Pyroptosis Compound Library;Glutamine Metabolism Compound Library;Anti-Pancreatic Cancer Compound […]

For research use only. We do not sell to patients. Tenovin-3 CAS No. : 1011301-27-1 Biological Activity：Tenovin-3 is a p53 activator[2]. Research Area：Cancer Targets：MDM-2/p53 Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Anti-Cancer Compound Library;Autophagy Compound Library;Anti-Aging Compound Library;Ferroptosis Compound Library;Pyroptosis Compound Library;Glutamine Metabolism Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Blood Cancer Compound Library;Anti-Cancer Metabolism Compound Library;Transcription Factor-Targeted […]