Tag: Inhibitor|Activator

For research use only. We do not sell to patients. ZJ43 CAS No. : 723331-20-2 Biological Activity：ZJ43 is a potent NAAG peptidase inhibitor, with an IC50 of 2.4 nM and a Ki of 0.8 nM. ZJ43 sufficiently activates group II mGluR and reduces some of the behavioral effects of PCP. ZJ43 shows an analgesic effect […]

For research use only. We do not sell to patients. AT9283 CAS No. : 896466-04-9 Biological Activity：AT9283 is a multi-targeted kinase inhibitor with potent activity against Aurora A/B, JAK2/3, Abl (T315I) and Flt3 (IC50s ranging from 1 to 30 nM). AT9283 inhibits growth and survival of multiple solid tumors in vitro and in vivo[2]. Research […]

For research use only. We do not sell to patients. ZLDI-8 CAS No. : 667880-38-8 Biological Activity：ZLDI-8 is a Notch activating/cleaving enzyme ADAM-17 inhibitor and inhibits the cleavage of Notch protein. ZLDI-8 decreases the expression of pro-survival/anti-apoptosis and epithelial-mesenchymal transition (EMT) related proteins. ZLDI-8 is also a competitive and irreversible tyrosine phosphatase (Lyp) inhibitor with […]

For research use only. We do not sell to patients. Pivanex CAS No. : 122110-53-6 Biological Activity：Pivanex (AN-9), a derivative of Butyric acid, is an orally active HDAC inhibitor. Pivanex down-regulates bcr-abl protein and enhances apoptosis. Pivanex has antimetastic and antiangiogenic properties. Research Area：Cancer|Inflammation/Immunology Targets：HDAC|Bcr-Abl|Apoptosis Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive […]

For research use only. We do not sell to patients. BS-181 CAS No. : 1092443-52-1 Biological Activity：BS-181 is a potent and selective CDK7 inhibitor (IC50=21 nM) than Seliciclib (HY-30237). BS-181 is also against CDK2, CDK5 and CDK9 with IC50 values of 880, 3000 and 4200 nM, respectively (fails to block CDK1, 4 and 6). BS-181 […]

For research use only. We do not sell to patients. Trametinib (DMSO solvate) CAS No. : 1187431-43-1 Biological Activity：Trametinib (DMSO solvate) (GSK-1120212 (DMSO solvate);JTP-74057 (DMSO solvate)) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM. Trametinib (DMSO solvate) activates autophagy and induces apoptosis[2]. Research Area：Cancer Targets：MEK|Apoptosis Related […]

For research use only. We do not sell to patients. Bicyclol CAS No. : 118159-48-1 Biological Activity：Bicyclol(SY 801) is a anti-hepatitis drug. Target: HBV Oral administration of bicyclol normalized the elevated serum transaminases (ALT, AST) by approximately 50% in chronic viral hepatitis B and C, and also showed certain level of inhibiting HBV and HCV […]

For research use only. We do not sell to patients. Coumermycin A1 CAS No. : 4434-05-3 Biological Activity：Coumermycin A1 is a JAK2 signal activator. Coumermycin A1 inhibits DNA Gyrase which thereby inhibits cell division in bacteria. Coumermycin A1 shows anti-orthopoxvirus activity. Research Area：Metabolic Disease Targets：JAK|Orthopoxvirus|Bacterial Related Small Molecules:AZ-3;Sandramycin;LLO (91-99);Gepotidacin;Oritavancin;Azlocillin sodium salt;JAK3/BTK-IN-1;Herbimycin A;Antibacterial agent 45;Leucomycin;Isouvaretin;Antibacterial agent […]

For research use only. We do not sell to patients. Sorafenib Tosylate CAS No. : 475207-59-1 Biological Activity：Sorafenib Tosylate (Bay 43-9006 Tosylate) is a potent and orally active Raf inhibitor with IC50s of 6 nM and 20 nM for Raf-1 and B-Raf, respectively. SorafenibTosylate is a multikinase inhibitor with IC50s of 90 nM, 15 nM, […]

For research use only. We do not sell to patients. Sepantronium bromide CAS No. : 781661-94-7 Biological Activity：Sepantronium bromide (YM-155) is a survivin inhibitor with an IC50 of 0.54 nM. Research Area：Cancer Targets：Autophagy|Survivin Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Apoptosis Compound Library;Anti-Cancer Compound Library;Clinical Compound Library;Autophagy Compound Library;Drug Repurposing […]