Tag: Antagonist|Activator

For research use only. We do not sell to patients. Avobenzone CAS No. : 70356-09-1 Biological Activity：Avobenzone, a dibenzoylmethane compound, is one of the most widely used filters in sunscreens for skin photoprotection in the UVA band. Avobenzone is an endocrine disruptor that directly binds to estrogen receptor β and acts as an estrogen agonist[2]. […]

For research use only. We do not sell to patients. Flupirtine-d4 hydrochloride CAS No. : 1324717-75-0 Biological Activity：Flupirtine-d4 (D 9998-d4) hydrochloride is the deuterium labeled Flupirtine. Flupirtine(D 9998) hydrochloride is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties[2]. Research Area：Neurological Disease Targets：Potassium Channel|iGluR Related Small Molecules:Kv3 modulator 2;CIQ;Quinolinic acid-d3;Brompheniramine-d6 maleate;Pinacidil;1-Aminocyclobutanecarboxylic […]

For research use only. We do not sell to patients. Candesartan Cilexetil CAS No. : 145040-37-5 Biological Activity：Candesartan Cilexetil (TCV-116) is an angiotensin II receptor antagonist used mainly for the treatment of hypertension. Target: Type-1 angiotensin II receptor Candesartan is generally well tolerated and significantly reduced cardiovascular deaths and hospital admissions for heart failure. Ejection […]

For research use only. We do not sell to patients. Macitentan CAS No. : 441798-33-0 Biological Activity：Macitentan (ACT-064992) is an orally active, non-peptide dual ETA and ETB (endothelin receptor) antagonist. Macitentan has the potential for idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH). Research Area：Cardiovascular Disease|Endocrinology|Cancer Targets：Endothelin Receptor|Apoptosis Related Screening Libraries:Drug Repurposing Compound Library […]

For research use only. We do not sell to patients. PU02 CAS No. : 313984-77-9 Biological Activity：PU02, a derivative of 6-MP (HY-13677), is a negative allosteric modulator (NAM) of 5-HT3 receptor, with IC50 values of 0.36 and 0.73 μM in HEK293 cells transfected with human 5-HT3A and 5-HT3AB receptors respectively[2]. Research Area：Cancer|Neurological Disease Targets：5-HT Receptor|Apoptosis […]

For research use only. We do not sell to patients. Minodronic acid CAS No. : 180064-38-4 Biological Activity：Minodronic acid (YM-529) is a third-generation bisphosphonate that directly and indirectly prevents proliferation, induces apoptosis, and inhibits metastasis of various types of cancer cells. Minodronic acid (YM-529) is an antagonist of purinergic P2X2/3 receptors involved in pain[2]. Research […]

For research use only. We do not sell to patients. Flupirtine CAS No. : 56995-20-1 Biological Activity：Flupirtine(D 9998) is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties. IC50 Value: Target: Potassium channel; NMDA receptor in vitro: High concentrations of flupirtine antagonized inward currents to NMDA(200 microM) at -70 mV with […]

For research use only. We do not sell to patients. Antagonist G TFA Biological Activity：Antagonist G TFA is a potent vasopressin antagonist. Antagonist G is also a weak antagonist of GRP and Bradykinin. Antagonist G induces AP-1 transcription and sensitizes cells to chemotherapy[2]. Research Area：Cancer Targets：Apoptosis|Vasopressin Receptor Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II […]

For research use only. We do not sell to patients. Penehyclidine CAS No. : 87827-02-9 Biological Activity：Penehyclidine, a anticholinergic agent, is a selective antagonist of M1 and M3 receptors. Penehyclidine activates NF-kβ in lung tissue and inhibits the release of inflammatory factors. Penehyclidine can alleviate the pulmonary inflammatory response in rats with chronic obstructive pulmonary […]

For research use only. We do not sell to patients. Zibotentan CAS No. : 186497-07-4 Biological Activity：Zibotentan (ZD4054) is a potent, selective and orally active endothelin A (ETA) receptor antagonist with a Ki of 13 nM. Zibotentan has no inhibitory effect on ETB. Zibotentan has anticancer effects and can be used for castration-resistant prostate cancer […]