Tag: Modulator|Inducer

For research use only. We do not sell to patients. MPP hydrochloride Biological Activity：MPP hydrochloride is a potent and selective ER (estrogen receptor) modulator. MPP hydrochloride induces significant apoptosis in the endometrial cancer and oLE cell lines. MPP hydrochloride reverses the positive effects of beta-estradiol. MPP hydrochloride has mixed agonist/antagonist action on murine uterine ERalpha […]

For research use only. We do not sell to patients. Anticancer agent 63 CAS No. : 2529657-32-5 Biological Activity：Anticancer agent 63 (compound 3h) shows active in reducing the viability of different cancer cell lines, including SW480, HeLa, A549 and MCF-7, with IC50 values at 24 h of 4.9, 11.5, 9.4, and 3.4 μM, respectively. Anticancer […]

For research use only. We do not sell to patients. Asiaticoside CAS No. : 16830-15-2 Biological Activity：Asiaticoside, a trisaccaride triterpene from Centella asiatica, suppresses TGF-β/Smad signaling through inducing Smad7 and inhibiting TGF-βRI and TGF-βRII in keloid fibroblasts; Asiaticoside shows antioxidant, anti-inflammatory, and anti-ulcer properties. Research Area：Inflammation/Immunology|Neurological Disease|Cardiovascular Disease|Cancer Targets：Reactive Oxygen Species|TGF-beta/Smad|Endogenous Metabolite|Apoptosis Related Screening Libraries:Natural […]

For research use only. We do not sell to patients. Sincalide ammonium CAS No. : 70706-98-8 Biological Activity：Sincalide ammonium (Cholecystokinin octapeptide ammonium, CCK-8 ammonium) is a rapid-acting amino acid polypeptide hormone analogue of cholecystokinin (CCK) for intravenous use in postevacuation cholecystography. Sincalide ammonium is a major bioactive segment of CCK that retains most of the […]

For research use only. We do not sell to patients. Toremifene citrate CAS No. : 89778-27-8 Biological Activity：Toremifene citrate (Z-Toremifene citrate) is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis. Toremifene citrate also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.07 µM and 2.6 µM, respectively[2]. […]

For research use only. We do not sell to patients. PB28 dihydrochloride CAS No. : 172907-03-8 Biological Activity：PB28 dihydrochloride, a cyclohexylpiperazine derivative, is a high affinity and selective sigma 2 (σ2) receptor agonist with a Ki of 0.68 nM. PB28 dihydrochloride is also a σ1 antagonist with a Ki of 0.38 nM. PB28 dihydrochloride is […]

For research use only. We do not sell to patients. ADH-6 CAS No. : 2227429-65-2 Biological Activity：ADH-6 is a tripyridylamide compound. ADH-6 abrogates self-assembly of the aggregation-nucleating subdomain of mutant p53 DBD. ADH-6 targets and dissociates mutant p53 aggregates in human cancer cells, which restores p53’s transcriptional activity, leading to cell cycle arrest and apoptosis. […]

For research use only. We do not sell to patients. PB28 CAS No. : 172906-90-0 Biological Activity：PB28 is a cyclohexylpiperazine derivative and a high affinity and selective sigma 2 (σ2) receptor agonist with a Ki of 0.68 nM. PB28 is also a σ1 antagonist with a Ki of 0.38 nM. PB28 is less affinity for […]

For research use only. We do not sell to patients. ACA-28 CAS No. : 948044-25-5 Biological Activity：ACA-28 (compound 2a) is a potent ERK MAPK signaling modulator. ACA-28 selectively inhibits cancer cell growth by inducing apoptosis with ERK hyperactivation ACA-28 inhibits cell growth of melanoma cells (SK-MEL-28) and normal melanocytes (NHEM), with IC50 values of 5.3 […]

For research use only. We do not sell to patients. Angiotensin II human acetate CAS No. : 68521-88-0 Biological Activity：Angiotensin II human (Angiotensin II) acetate is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human acetate plays a central role in regulating human blood pressure, which is mainly mediated by […]