haoyuan2014 - epigenetics modulation frontier

Kanamycins sulfate

Posted on March 22, 2025March 20, 2025 by haoyuan2014

Description Kanamycins sulfate is a broad-spectrum antibiotic, can be used in certain severe staphylococcal or Gram-negative bacillary infections. Kanamycin sulfate has certain ototoxicity[1][2]. Molecular Weight：582.58 Formula：C18H38N4O15S CAS No.：70560–51–9 Appearance：Solid Color：White to off-white SMILES：[Kanamycins (sulfate)] Shipping：Room temperature in continental US; may vary elsewhere. Storage：4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month […]

Clazosentan

Posted on March 21, 2025March 20, 2025 by haoyuan2014

Description：Clazosentan (Ro 61–1790) is a selective endothelin A (ETA) receptor antagonist. Clazosentan inhibits ET-1-mediated vasoconstriction. Clazosentan prevents cerebral vasospasm, vasospasm-related cerebral infarction[1][5]. In Vitro：Clazosentan (0.1 μM) inhibits the ETA receptor in cerebral arteries[3]. Clazosentan is a substrate of the organic anion-transporting polypeptide (OATP) 1B1/1B3[5]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for […]

Nemonoxacin

Posted on March 20, 2025March 20, 2025 by haoyuan2014

Description：Nemonoxacin (TG-873870) is an orally active and potent broad-spectrum antibiotic. Nemonoxacin shows good inhibitory activity against different species of staphylococci, streptococci, and enterococci, Neisseria gonorrhoeae, and Haemophilus influenza. Nemonoxacin can be used in the study of bacterial infections and community-acquired pneumonia[1][2][3]. IC50 & Target：Bacterial[1][2][3]. In Vitro：Nemonoxacin (0–5.51 µM; 24 h) shows good antibacterial activity in vitro[1]. MedChemExpress (MCE) has not independently confirmed the […]

GJ103 and Lamin B1 Antibody: How to Conduct Chronic Kidney Disease Research?

Posted on March 19, 2025March 19, 2025 by haoyuan2014

Chronic kidney disease (CKD) poses a significant global health issue, leading to the progressive loss of kidney function. Renal fibrosis commonly accompanies CKD, characterized by excessive deposition of extracellular matrix (ECM). This process causes tissue remodeling and scarring in the renal parenchyma. Myofibroblasts drive renal fibrosis through their proliferation and activation. 1. Role of Meis1 in CKD […]

GMP Small Molecules Empower Cell Therapy: Reshaping the Future of Medicine

Posted on March 19, 2025March 19, 2025 by haoyuan2014

In early January 2025, MIT Tech Review unveiled its annual list of top 10 breakthrough technologies poised to redefine the future. Among these, stem cell therapy stood out for its potential to treat diverse diseases—including neurodegenerative disorders, diabetes, cancer, and heart failure. This groundbreaking approach uses stem cells to replace damaged cells, offering hope for […]

AI Deep Learning Accelerates Drug Development

Posted on March 18, 2025March 18, 2025 by haoyuan2014

Deep learning is a subset of artificial intelligence (AI) that mimics the neural networks of the human brain to learn from large amounts of data, enabling machines to solve complex problems. Deep learning technology has made significant progress in the biomedical field. Researchers have developed a series of application based on deep learning for disease […]

ZYZ-488

Posted on March 18, 2025 by haoyuan2014

Product Name : ZYZ-488Description:ZYZ-488 is a competitive apoptotic protease activating factor-1 (Apaf-1) inhibitor. ZYZ-488 inhibits the activation of binding protein procaspase-9 and procaspase-3.CAS: 1470302-79-4Molecular Weight:487.46Formula: C20H29N3O11Chemical Name: (2S, 3S, 4S, 5R, 6S)-6-4-[(4-carbamimidamidobutoxy)carbonyl]-2, 6-dimethoxyphenoxy-3, 4, 5-trihydroxyoxane-2-carboxylic acidSmiles : COC1=CC(=CC(OC)=C1O[C@@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C(O)=O)C(=O)OCCCCNC(N)=NInChiKey: PVTAIJDQJJZCJP-WXZWTWHISA-NInChi : InChI=1S/C20H29N3O11/c1-30-10-7-9(18(29)32-6-4-3-5-23-20(21)22)8-11(31-2)15(10)33-19-14(26)12(24)13(25)16(34-19)17(27)28/h7-8,12-14,16,19,24-26H,3-6H2,1-2H3,(H,27,28)(H4,21,22,23)/t12-,13-,14+,16-,19+/m0/s1Purity: ≥98% (or refer to the Certificate of Analysis)Shipping Condition: Shipped under ambient temperature as […]

PTX3 (human), (recombinant)

Posted on March 17, 2025 by haoyuan2014

Product Name : PTX3 (human), (recombinant)Sequence: Purity: Molecular Weight:~42kDa. Due to glycosylation, PTX3 may migrate between 40-45kDa.Solubility : Appearance: Use/Stability : Description: CAS : Solubility: Formula: Additional Information : | Alternative Name Pentraxin 3, TSG14, TNF stimulated gene-14 | Application Notes ELISA and Western blot standard together with MAb to PTX3 ) and PAb to […]

Ginsenoside Rh2

Posted on March 17, 2025 by haoyuan2014

Product Name : Ginsenoside Rh2Description:Ginsenoside Rh2 is isolated from the root of Ginseng. Ginsenoside Rh2 induces the activation of caspase-8 and caspase-9. Ginsenoside Rh2 induces cancer cell apoptosis in a multi-path manner.CAS: 78214-33-2Molecular Weight:622.87Formula: C36H62O8Chemical Name: (2R, 3R, 4S, 5S, 6R)-2-{[(1S, 3aR, 3bR, 5aR, 7S, 9aR, 9bR, 11R, 11aR)-11-hydroxy-1-[(2S)-2-hydroxy-6-methylhept-5-en-2-yl]-3a, 3b, 6, 6, 9a-pentamethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-7-yl]oxy}-6-(hydroxymethyl)oxane-3, 4, 5-triolSmiles […]

PDK1 polyclonal antibody

Posted on March 16, 2025 by haoyuan2014

Product Name : PDK1 polyclonal antibodySequence: Purity: Molecular Weight:Solubility : Appearance: Use/Stability : Description: PDK-1 (Pyruvate dehydrogenase kinase-1) is a 48 kDa protein kinase. It is a member of the mitrochondrial matrix protein kinase family and is related to the histidine protein kinases found in prokaryotes. PDK-1 is responsible for phosphorylation and concomitant inactivation of […]