Tag: Inhibitor|Inducer

For research use only. We do not sell to patients. Bomedemstat ditosylate CAS No. : 1990504-72-7 Biological Activity：Bomedemstat (IMG-7289) ditosylate is an orally active and irreversible lysine-specific demethylase 1 (LSD1) inhibitor. Bomedemstat ditosylate can increase H3K4 and H3K9 methylation, and then alter gene expression. Bomedemstat ditosylate shows anti-cancer activities, inhibits cancer cell proliferation and induces […]

For research use only. We do not sell to patients. Enpp/Carbonic anhydrase-IN-1 Biological Activity：Enpp/Carbonic anhydrase-IN-1 (compound 1e) is a potent Enpp and carbonic anhydrase inhibitor with IC50s of 1.36, 1.35, 3.00, 0.88, 1.02 µM for NPP1, NPP2, NPP3, CA-II, CA-IX respectively. Enpp/Carbonic anhydrase-IN-1 shows antiproliferative activity for cancer cells and low cytotoxic against normal cells. […]

For research use only. We do not sell to patients. Dinaciclib CAS No. : 779353-01-4 Biological Activity：Dinaciclib (SCH 727965) is a potent inhibitor of CDK, with IC50s of 1 nM, 1 nM, 3 nM, and 4 nM for CDK2, CDK5, CDK1, and CDK9, respectively. Research Area：Cancer Targets：CDK|Apoptosis Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug […]

For research use only. We do not sell to patients. Cambinol CAS No. : 14513-15-6 Biological Activity：Cambinol is a SIRT1 and SIRT2 inhibitor with IC50 values of 56 μM and 59 μM, respectively. Cambinol is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor)[2]. Research Area：Cancer Targets：Sirtuin|Apoptosis|Phospholipase Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound […]

For research use only. We do not sell to patients. Bafetinib CAS No. : 859212-16-1 Biological Activity：Bafetinib is a potent and orally active Lyn/Bcr-Abl tyrosine kinase inhibitor. Bafetinib augments the activities of several proapoptotic Bcl-2 homology (BH)3-only proteins (Bim, Bad, Bmf and Bik) and induces apoptosis in Ph+ leukemia cells via Bcl-2 family-regulated intrinsic apoptosis […]

For research use only. We do not sell to patients. STAT3-IN-10 CAS No. : 2499491-04-0 Biological Activity：STAT3-IN-10 is a STAT3 inhibitor with an IC50 value of 5.18 µM. STAT3-IN-10 directly binds to STAT3 SH2 domain, induces cancer cells apoptosis. Research Area：Cancer Targets：STAT|Apoptosis Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;BJE6-106;Dinaciclib;Cirsilineol;Ecteinascidin 770;MDM2-p53-IN-15;Ochromycinone;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;Xevinapant;Mangiferin;Cambinol;Antioxidant agent-5;Apoptosis inducer 9;Bafetinib;Cyclovirobuxine […]

For research use only. We do not sell to patients. Rigosertib sodium CAS No. : 592542-60-4 Biological Activity：Rigosertib sodium (ON-01910 sodium) is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition the PI3K/Akt pathway, promotes the phosphorylation of histone H2AX and induces G2/M arrest in cell cycle[2]. Rigosertib sodium is a […]

For research use only. We do not sell to patients. (R)-Verapamil-d7 hydrochloride Biological Activity：(R)-Verapamil D7 hydrochloride ((R)-(+)-Verapamil D7 hydrochloride) is a deuterium labeled (R)-Verapamil hydrochloride. (R)-Verapamil hydrochloride ((R)-(+)-Verapamil hydrochloride) is a P-Glycoprotein inhibitor. (R)-Verapamil hydrochloride blocks MRP1 mediated transport, resulting in chemosensitization of MRP1-overexpressing cells to anticancer drugs[2]. Research Area：Cancer Targets：P-glycoprotein|Apoptosis Related Small Molecules:Physalin A;Bomedemstat […]

For research use only. We do not sell to patients. LSD1/ER-IN-1 Biological Activity：LSD1/ER-IN-1 (compound 11g) is a potent ER and LSD1 inhibitor, with an IC50 of 1.55 μM (LSD1). LSD1/ER-IN-1 has high affinity selectivity for ERα protein, with α/β ratio of 7.11. LSD1/ER-IN-1 shows good antiproliferative activity against MCF-7 breast cancer cells, with an IC50 […]

For research use only. We do not sell to patients. JGB1741 CAS No. : 1256375-38-8 Biological Activity：JGB1741 (ILS-JGB-1741) is a potent and specific SIRT1 activity inhibitor with an IC50 of ∼15 μM. JGB1741 is a weak SIRT2 and SIRT3 inhibitor with an all IC50>100 μM. JGB1741 increases the acetylated p53 levels leading to p53-mediated apoptosis […]