Tag: Inhibitor|Agonist

For research use only. We do not sell to patients. Fluticasone propionate-d3 Biological Activity：Fluticasone propionate-d3 is the deuterium labeled Fluticasone propionate. Fluticasone propionate, a potent topical anti-inflammatory corticosteroid, is a selective glucocorticoid receptor agonist, with an absolute affinity (KD) of 0.5 nM. Fluticasone propionate shows little or no activity at other steroid receptors. Anti-viral activity[2]. […]

For research use only. We do not sell to patients. 5-Aminosalicylic Acid-D3 hydrochloride CAS No. : 1346601-18-0 Biological Activity：5-Aminosalicylic Acid-D3 (Mesalamine-D3) hydrochloride is the deuterium labeled 5-Aminosalicylic Acid. 5-Aminosalicylic acid (Mesalamine) hydrochloride acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB. Research Area：Inflammation/Immunology|Cancer Targets：PAK|NF-κB|PPAR|Endogenous Metabolite Related Small Molecules:D-α-Hydroxyglutaric acid […]

For research use only. We do not sell to patients. Loratadine-d5 CAS No. : 1398065-63-8 Biological Activity：Loratadine-d5 (Loratidine-d5) is the deuterium labeled Loratadine. Loratadine (SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. Loratadine has anti-dengue-virus (DENV) activity. Loratadine can inhibit immunologic release of inflammatory mediators. Research Area：Infection|Endocrinology|Inflammation/Immunology Targets：Influenza […]

For research use only. We do not sell to patients. MeBIO CAS No. : 667463-95-8 Biological Activity：MeBIO is a potent AhR (aryl hydrocarbon receptor) agonist, with IC50 of 44 μM (GSK-3) and 55 μM (CDK1/cyclin B), respectively. MeBIO is inactive on GSK-3β. Research Area：Others Targets：CDK|GSK-3|Aryl Hydrocarbon Receptor Related Screening Libraries:Bioactive Compound Library Plus;Cell Cycle/DNA Damage […]

For research use only. We do not sell to patients. Ginsenoside Rc CAS No. : 11021-14-0 Biological Activity：Ginsenoside Rc, one of major Ginsenosides from Panax ginseng, enhances GABA receptorA (GABAA)-mediated ion channel currents (IGABA). Ginsenoside Rc inhibits the expression of TNF-α and IL-1β. Research Area：Cancer|Inflammation/Immunology|Neurological Disease Targets：TNF Receptor|Interleukin Related|GABA Receptor Related Screening Libraries:Natural Product Library […]

For research use only. We do not sell to patients. 5-Aminosalicylic Acid CAS No. : 89-57-6 Biological Activity：5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB. Research Area：Inflammation/Immunology|Cancer Targets：PAK|NF-κB|PPAR|Endogenous Metabolite Related Screening Libraries:Natural Product Library Plus;Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive […]

For research use only. We do not sell to patients. Corydaline CAS No. : 518-69-4 Biological Activity：Corydaline ((+)-Corydaline), an isoquinoline alkaloid isolated from Corydalis yanhusuo, is an AChE inhibitor with an IC50 of 226 µM. Corydaline is a μ-opioid receptor (Ki of 1.23 µM) agonist and inhibits enterovirus 71 (EV71) replication (IC50 of 25.23 µM). […]

For research use only. We do not sell to patients. (R)-Praziquantel-d11 CAS No. : 1399880-38-6 Biological Activity：(R)-Praziquantel D11 is the deuterium labeled (R)-Praziquantel. (R)-Praziquantel, the active enantiomer of Praziquantel, is a partial agonist of the human 5-HT2B receptor. (R)-Praziquantel acts as an antischistosomal eutomer. Research Area：Infection Targets：Parasite|5-HT Receptor Related Small Molecules:(+)-Isopulegol;F 13714;SR9186;Antileishmanial agent-2;Azlocillin sodium salt;Mosapride-d5;Nuciferine;SQ109;Trypanothione […]

For research use only. We do not sell to patients. Beclometasone dipropionate CAS No. : 5534-09-8 Biological Activity：Beclometasone dipropionate, the prodrug of Beclometasone, is an orally active and potent glucocorticoid recepter agonist. Beclometasone dipropionate acts via a glucocorticoid receptor and suppresses inflammation and hyperproliferation. Beclometasone dipropionate can be used for asthma [2]. Research Area：Inflammation/Immunology|Endocrinology Targets：Glucocorticoid […]

For research use only. We do not sell to patients. 6-OAU CAS No. : 83797-69-7 Biological Activity：6-OAU (GTPL5846) (6-n-octylaminouracil) is an GPR84 (G protein-coupled receptor 84) agonist, with an EC50 value of 105 nM. 6-OAU works as a chemoattractant to both PMNs and macrophages, and amplifies the proinflammatory cytokine IL-8, shows proinflammatory function. 6-OAU also […]