Tag: Antagonist|Agonist

For research use only. We do not sell to patients. Navafenterol saccharinate CAS No. : 1648550-37-1 Biological Activity：Navafenterol (AZD-8871) saccharinate is an inhaled dual-acting, potent, selective, and long-lasting M3-antagonist/β2-agonist (MABA) with long-lasting effects and favorable safety profile. The pIC50 is 9.5 for human M3 receptor, and the pEC50 is 9.5 for β2-adrenoceptor. Navafenterol saccharinate can be used for […]

For research use only. We do not sell to patients. Tropisetron CAS No. : 89565-68-4 Biological Activity：Tropisetron (SDZ-ICS-930 free base) is a selective 5-HT3 receptor antagonist and α7-nicotinic receptor agonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor. IC50 value: 70.1 ± 0.9 nM [1] Target: 5-HT3 receptor in vitro: Tropisetron specifically […]

For research use only. We do not sell to patients. Urapidil hydrochloride CAS No. : 64887-14-5 Biological Activity：Urapidil hydrochloride is an orally active α1-adrenoceptor antagonist and 5-HT1A receptor agonist with a pIC50 of 6.13 and 4.38 against α1- and α2-adrenoceptor, respectively. Urapidil hydrochloride shows antihypertensive effect[2]. Research Area：Cardiovascular Disease|Endocrinology Targets：Adrenergic Receptor|5-HT Receptor Related Screening Libraries:Drug […]

For research use only. We do not sell to patients. Ursodeoxycholic acid-d5 CAS No. : 93701-18-9 Biological Activity：Ursodeoxycholic acid-d5 (Ursodiol-d5) is the deuterium labeled Ursodeoxycholic acid. Ursodeoxycholic acid (Ursodeoxycholate) is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and […]

For research use only. We do not sell to patients. Nemonapride CAS No. : 75272-39-8 Biological Activity：Nemonapride is a highly potent dopamine D2 receptor antagonist with a Ki of 0.06 nM. Nemonapride also activates 5-HT1A receptor with an IC50 of 34 nM. Nemonapride is an antipsychotic that readily passes through the blood brain barrier and […]

For research use only. We do not sell to patients. Navafenterol CAS No. : 1435519-06-4 Biological Activity：Navafenterol (AZD-8871) is an inhaled dual-acting, potent, selective, and long-lasting M3-antagonist/β2-agonist (MABA) with long-lasting effects and favorable safety profile. The pIC50 is 9.5 for human M3 receptor, and the pEC50 is 9.5 for β2-adrenoceptor. Navafenterol can be used for the research of […]

For research use only. We do not sell to patients. Agomelatine-d6 CAS No. : 1079389-42-6 Biological Activity：Agomelatine-d6 (S-20098-d6) is deuterium labeled Agomelatine. Agomelatine is a specific agonist of MT1 and MT2 receptors . Research Area：Neurological Disease Targets：5-HT Receptor|Melatonin Receptor Related Small Molecules:F 13714;Mosapride-d5;Nuciferine;Renzapride;Melatonin-d3;LY 344864 racemate;Harmine hydrochloride;Valerenic acid;Arotinolol;Melitracen-d6 hydrochloride;WAY-100635;Nelotanserin;Flupentixol-d4 dihydrochloride;Cariprazine-d6 hydrochloride;Tetrahydro-β-carboline;CP-809101;Volinanserin-d4 hydrochloride;Masupirdine free base;BRL-15572 dihydrochloride;LY393558 Trending […]

For research use only. We do not sell to patients. Triciferol CAS No. : 957214-00-5 Biological Activity：Triciferol functions as a multiple ligand with combined VDR agonist and HDAC antagonist activities. Triciferol binds directly to the VDR (IC50=87 nM), and functions as an agonist with 1,25D-like potency on several 1,25D target genes. Triciferol induces marked tubulin […]

For research use only. We do not sell to patients. Agomelatine CAS No. : 138112-76-2 Biological Activity：Agomelatine (S-20098) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively. Agomelatine is a selective 5-HT2C receptor antagonist with pKis of 6.4 and […]

For research use only. We do not sell to patients. EST73502 monohydrochloride CAS No. : 2535970-65-9 Biological Activity：EST73502 monohydrochloride is a selective, orally active and blood-brain barrier (BBB) penetrant dual μ-opioid receptor (MOR) agonist and σ1 receptor (σ1R) antagonist, with Kis of 64 nM and 118 nM for MOR and σ1R, respectively. EST73502 monohydrochloride has […]