Tag: Antagonist

For research use only. We do not sell to patients. Nicotinamide N-oxide CAS No. : 1986-81-8 Biological Activity：Nicotinamide N-oxide, an in vivo nicotinamide metabolite, is a potent, and selective antagonist of the CXCR2 receptor. Research Area：Inflammation/Immunology|Endocrinology Targets：Drug Metabolite|CXCR|Endogenous Metabolite Related Screening Libraries:Natural Product Library Plus;Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Immunology/Inflammation Compound Library;Metabolism/Protease Compound Library;Natural […]

For research use only. We do not sell to patients. V116517 CAS No. : 1073616-61-1 Biological Activity：V116517 is a potent, orally active transient receptor potential vanilloid (TRPV1) antagonist. V116517 shows potent activity in inhibiting both capsaicin (CAP)- and acid (pH 5)-induced currents in rat DRG neurons expressing native TRPV (IC50=423.2 nM for CAP; IC50=180.3 nM […]

For research use only. We do not sell to patients. GNE-6468 CAS No. : 1677668-27-7 Biological Activity：GNE-6468 is a highly potent and selective RORγ (RORc) inverse agonist with an EC50 value of 13 nM for HEK-293 cell. GNE-6468 exhibits an EC50 of 30 nM for IL-17 PBMC. Research Area：Inflammation/Immunology Targets：ROR Related Screening Libraries:Bioactive Compound Library […]

For research use only. We do not sell to patients. SR3335 CAS No. : 293753-05-6 Biological Activity：SR3335 (ML 176) is a selective RORα inverse agonist that directly binds to RORα with a Ki of 220 nM[2]. Research Area：Metabolic Disease Targets：ROR Related Screening Libraries:Bioactive Compound Library Plus;Metabolism/Protease Compound Library;Small Molecule Immuno-Oncology Compound Library;Anti-diabetic Compound Library;Transcription Factor-Targeted […]

For research use only. We do not sell to patients. NTRC-824 CAS No. : 1623002-61-8 Biological Activity：NTRC-824 (Compound 5) is a potent, selective and neurotensin-like nonpeptide neurotensin receptor type 2 (NTS2) antagonist with an IC50 of 38 nM and a Ki of 202 nM. NTRC-824 is >150-fold selectivity for NTS2 over NTS1 (Ki >30 μM). […]

For research use only. We do not sell to patients. Alizapride hydrochloride CAS No. : 59338-87-3 Biological Activity：Alizapride is a potent antiemetic, acting as a dopamine receptor antagonist. Alizapride also used in human digestive disorders[3]. Research Area：Cancer|Neurological Disease Targets：Dopamine Receptor Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library […]

For research use only. We do not sell to patients. LY3020371 hydrochloride CAS No. : 1377615-44-5 Biological Activity：LY3020371 hydrochloride is a potent, selective metabotropic glutamate 2/3 receptor (mGlu2/3) antagonist with Ki of 5.3 and 2.5 nM, potently blocks cAMP formation with IC50 of 16.2 nM. LY3020371 hydrochloride exerts an antidepressant-like signature in vivo[2]. Research Area：Neurological […]

For research use only. We do not sell to patients. ORL1 antagonist 1 CAS No. : 1174985-59-1 Biological Activity：ORL1 antagonist 1 is an opioid receptor-like 1 (ORL1) antagonist with an IC50 of 61 nM. Research Area：Metabolic Disease|Neurological Disease Targets：Opioid Receptor Related Small Molecules:Loperamide-d6 N-Oxide;Deltorphin 2 TFA;Nalfurafine;β-Lipotropin (60-65);GSK1521498 free base;Trimebutine-d5 fumarate;Dynorphin B (1-13) (TFA);Dermorphin Analog;β-Endorphin (6-31), […]

For research use only. We do not sell to patients. GSK2332255B CAS No. : 1366233-41-1 Biological Activity：GSK2332255B is a potent, selective TRPC3 and TRPC6 antagonist with IC50s of 5 nM and 4 nM for rat TRPC3 and rat TRPC6. GSK2332255B shows ≥100-fold selectivity for TRPC3/6 over other calcium-permeable channels. Research Area：Cardiovascular Disease Targets：TRP Channel Related […]

For research use only. We do not sell to patients. Loxiglumide CAS No. : 107097-80-3 Biological Activity：Loxiglumide is a cholecystokinin (CCK-1) receptor antagonist. Research Area：Metabolic Disease|Endocrinology Targets：Cholecystokinin Receptor Related Screening Libraries:Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Neuronal Signaling Compound Library;Endocrinology Compound Library;Neurotransmitter Receptor Compound Library;Targeted Diversity Library;Human Metabolite Library; Related Small Molecules:Gastrin I, human;(Rac)-Sograzepide;Nastorazepide;Proglumide;Lorglumide sodium […]