Tag: Inhibitor|MDM2 Inhibitor

For research use only. We do not sell to patients. p53 and MDM2 proteins-interaction-inhibitor (racemic) CAS No. : 939983-14-9 Biological Activity：p53 and MDM2 proteins-interaction-inhibitor (racemic) (Compound 2j) is an inhibitor of the interaction between p53 and MDM2 proteins. Research Area：Cancer Targets：MDM-2/p53|E1/E2/E3 Enzyme Related Small Molecules:UBE2T/FANCL-IN-1;MDM2-p53-IN-15;MC-VC-PABC-SP 141;Navtemadlin;MD-224;DI-1859;Mutant p53 modulator-1;MDM2/4-p53-IN-2;MX69;p-nitro-Pifithrin-α;RG7112;MMRi62;Anticancer agent 50;NSC59984;Pifithrin-β hydrobromide;Ivaltinostat formic;GEM-5;Teslexivir;TRAF6 peptide;Tenovin-6;PK11007;AM-8735;NAcM-OPT;GN25;RO-5963;PhiKan 083;C16-Ceramide;Pifithrin-α hydrobromide […]

For research use only. We do not sell to patients. Navtemadlin CAS No. : 1352066-68-2 Biological Activity：Navtemadlin (AMG 232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction, with an IC50 of 0.6 nM. Navtemadlin binds to MDM2 with a Kd of 0.045 nM[2]. Research Area：Cancer Targets：MDM-2/p53|E1/E2/E3 Enzyme Related Screening Libraries:Drug Repurposing Compound […]

For research use only. We do not sell to patients. MD-224 CAS No. : 2136247-12-4 Biological Activity：MD-224 is a first-in-class and highly potent small-molecule human murine double minute 2 (MDM2) degrader based on the proteolysistargeting chimera (PROTAC) concept. MD-224 consists of ligands for Cereblon and MDM2. MD-224 induces rapid degradation of MDM2 at concentrations

For research use only. We do not sell to patients. RG7112 CAS No. : 939981-39-2 Biological Activity：RG7112 is a potent, selective, first clinical, orally active and blood-brain barrier crossed MDM2-p53 inhibitor, with an IC50 of 18 nM and a KD of 11 nM for binding to MDM2. Research Area：Cancer Targets：MDM-2/p53|E1/E2/E3 Enzyme Related Screening Libraries:Clinical Compound […]

For research use only. We do not sell to patients. Siremadlin CAS No. : 1448867-41-1 Biological Activity：Siremadlin (NVP-HDM201) is a potent, orally bioavailable and highly specific p53-MDM2 interaction inhibitor. Research Area：Cancer Targets：MDM-2/p53|E1/E2/E3 Enzyme Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Apoptosis Compound Library;Metabolism/Protease Compound Library;Anti-Cancer Compound Library;Clinical Compound Library;Autophagy Compound […]

For research use only. We do not sell to patients. SJ-172550 CAS No. : 431979-47-4 Biological Activity：SJ-172550 is a small molecule inhibitor of MDMX; competes for the wild type p53 peptide binding to MDMX with an EC50 of 5 μM. Research Area：Cancer Targets：MDM-2/p53|E1/E2/E3 Enzyme Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Metabolism/Protease Compound Library;Anti-Cancer Compound […]

For research use only. We do not sell to patients. MI-773 CAS No. : 1303607-07-9 Biological Activity：MI-773 is a potent MDM2-p53 protein‐protein interaction (PPI) inhibitor with high binding affinity against MDM2 (Kd=8.2 nM). MI-773 has antitumor activity[2]. Research Area：Cancer Targets：MDM-2/p53|E1/E2/E3 Enzyme Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Metabolism/Protease Compound Library;Anti-Cancer Compound Library;Autophagy Compound Library;Peptidomimetic […]

For research use only. We do not sell to patients. MD-222 CAS No. : 2136246-72-3 Biological Activity：MD-222 is the first-in-class highly potent PROTAC degrader of MDM2. MD-222 consists of ligands for Cereblon and MDM2. MD-222 induces rapid degradation of the MDM2 protein and activation of wild-type p53 in cells. MD-222 has anticancer effects[2]. Research Area：Cancer […]

For research use only. We do not sell to patients. CTX1 CAS No. : 501935-96-2 Biological Activity：CTX1 is a p53 activator that overcomes HdmX-mediated p53 repression. CTX1 exhibits potent anti-cancer activity in a mouse acute myeloid leukemia (AML) model system. Research Area：Cancer Targets：MDM-2/p53|E1/E2/E3 Enzyme Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Metabolism/Protease Compound Library;Anti-Cancer Compound […]

For research use only. We do not sell to patients. p53 and MDM2 proteins-interaction-inhibitor (chiral) CAS No. : 939981-37-0 Biological Activity：p53 and MDM2 proteins-interaction-inhibitor (chiral) (Compound 32) is an inhibitor of the interaction between p53 and MDM2 proteins. Research Area：Cancer Targets：MDM-2/p53|E1/E2/E3 Enzyme Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Metabolism/Protease Compound Library;Anti-Cancer Compound Library;Autophagy Compound […]