Tag: Activator|Inhibitor

For research use only. We do not sell to patients. Niraparib tosylate CAS No. : 1038915-73-9 Biological Activity：Niraparib tosylate (MK-4827 tosylate) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with an IC50 of 3.8 and 2.1 nM, respectively. Niraparib tosylate leads to inhibition of repair of DNA damage, activates apoptosis and shows […]

For research use only. We do not sell to patients. Batabulin sodium CAS No. : 195533-98-3 Biological Activity：Batabulin sodium (T138067 sodium) is an antitumor agent, which binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. Batabulin sodium affects cell morphology and leads to cell-cycle arrest ultimately induces apoptotic cell […]

For research use only. We do not sell to patients. I-CBP112 CAS No. : 1640282-31-0 Biological Activity：I-CBP112 is a specific and potent acetyl-lysine competitive protein-protein interaction inhibitor, that inhibits the CBP/p300 bromodomains, enhances acetylation by p300. Research Area：Cancer Targets：Epigenetic Reader Domain|Histone Acetyltransferase Related Screening Libraries:Bioactive Compound Library Plus;Epigenetics Compound Library;Histone Modification Research Compound Library;Anti-Cancer Compound […]

For research use only. We do not sell to patients. NL-1 CAS No. : 188532-26-5 Biological Activity：NL-1 is a mitoNEET inhibitor with antileukemic effect. NL-1 inhibits REH and REH/Ara-C cells growth with IC50s of 47.35 µM and 56.26 µM, respectively. NL-1-mediated death in leukemic cells requires the activation of the autophagic pathway. Research Area：Cancer Targets：Autophagy|Mitochondrial […]

For research use only. We do not sell to patients. Enoxacin-d8 CAS No. : 1329642-60-5 Biological Activity：Enoxacin-d8 (AT 2266-d8) is the deuterium labeled Enoxacin. Enoxacin (AT 2266), a fluoroquinolone, interferes with DNA replication and inhibits bacterial DNA gyrase (IC50=126 µg/ml) and topoisomerase IV (IC50=26.5 µg/ml). Enoxacin is a miRNA processing activator and enhances siRNA-mediated mRNA […]

For research use only. We do not sell to patients. Pravastatin sodium CAS No. : 81131-70-6 Biological Activity：Pravastatin sodium (CS-514 sodium) is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM. Research Area：Cardiovascular Disease|Cancer Targets：Ferroptosis|Autophagy|HMG-CoA Reductase (HMGCR) Related Screening Libraries:Natural Product Library Plus;Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library […]

For research use only. We do not sell to patients. (-)-Epicatechin CAS No. : 490-46-0 Biological Activity：(-)-Epicatechin inhibits cyclooxygenase-1 (COX-1) with an IC50 of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB. Research Area：Cancer|Inflammation/Immunology Targets：Ferroptosis|Endogenous Metabolite|COX Related Screening Libraries:Natural Product Library Plus;Drug Repurposing […]

For research use only. We do not sell to patients. S2116 CAS No. : 2262489-89-2 Biological Activity：S2116, a N-alkylated tranylcypromine (TCP) derivative, is a potent lysine-specific demethylase 1 (LSD1) inhibitor. S2116 increases H3K9 methylation and reciprocal H3K27 deacetylation at super-enhancer regions. S2116 induces apoptosis in TCP-resistant T-cell acute lymphoblastic leukemia (T-ALL) cells by repressing transcription […]

For research use only. We do not sell to patients. POMHEX CAS No. : 2004714-34-3 Biological Activity：POMHEX, a racemic mixture and a cell-permeable pivaloyloxymethyl (POM) prodrug of HEX, is a potent, ENO2-specific inhibitor of enolase. POMHEX exhibits low-nanomolar potency against ENO1-deleted cells in vitro and is capable of eradicating ENO1-deleted xenografted tumours in vivo. POMHEX […]

For research use only. We do not sell to patients. Rifamycin S CAS No. : 13553-79-2 Biological Activity：Rifamycin S, a quinone, is an antibiotic against Gram-positive bacteria (including MRSA). Rifamycin S is the oxidized forms of a reversible oxidation-reduction system involving two electrons. Rifamycin S generates reactive oxygen species (ROS) and inhibits microsomal lipid peroxidation. […]