Tag: Agonist|Activator

For research use only. We do not sell to patients. Goserelin acetate CAS No. : 145781-92-6 Biological Activity：Goserelin acetate (ICI-118630 acetate), a decapeptide analogue of gonadotropin-releasing hormone (GnRH/LHRH), functions as a GnRH agonist. Goserelin acetate can be used for the research of breast cancer, epithelial ovarian cancer and prostate cancer[2]. Research Area：Endocrinology|Cancer Targets：GnRH Receptor|Apoptosis Related […]

For research use only. We do not sell to patients. Rilmenidine CAS No. : 54187-04-1 Biological Activity：Rilmenidine, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine is an alpha 2-adrenoceptor agonist. Rilmenidine induces autophagy. Rilmenidine acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na+/H+ […]

For research use only. We do not sell to patients. AS1269574 CAS No. : 330981-72-1 Biological Activity：AS1269574 is a potent, orally available GPR119 agonist, with an EC50 of 2.5 μM in HEK293 cells expressing human GPR119. AS1269574 activates TRPA1 cation channels to stimulate glucagon-like peptide-1 (GLP-1) secretion. AS1269574 specifically induces glucose-dependent insulin secretion from pancreatic […]

For research use only. We do not sell to patients. Etilefrine CAS No. : 709-55-7 Biological Activity：Etilefrine (3-[2-(ethylamino)-1-hydroxyethyl]phenol) is an α adrenergic agonist[2]. Etilefrine also is an AMPK activator. Etilefrine can be used for the research of postural hypotension[3]. Research Area：Cardiovascular Disease Targets：Adrenergic Receptor|AMPK Related Small Molecules:AMPK activator 4;Todralazine;ARC 239 dihydrochloride;Yohimbine;Glaucine;Salbutamol;BI-167107;Talibegron hydrochloride;ZLN024;YLF-466D;Arotinolol;SR59230A;BAY-3827;Higenamine hydrochloride;Navafenterol saccharinate;Isoprenaline hydrochloride […]

For research use only. We do not sell to patients. Adapalene sodium salt CAS No. : 911110-93-5 Biological Activity：Adapalene (CD271) sodium salt, a third-generation synthetic retinoid, is widely used for the research of acne. Adapalene sodium salt is a potent RAR agonist, with AC50s of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, […]

For research use only. We do not sell to patients. PRE-084 hydrochloride CAS No. : 75136-54-8 Biological Activity：PRE-084 hydrochloride is a highly selective σ1 receptor (S1R) agonist, with an IC50 of 44 nM. PRE-084 hydrochloride exhibits good neuroprotective effects, can improve motor function and motor neuron survival in mice. PRE-084 hydrochloride also can ameliorate myocardial […]

For research use only. We do not sell to patients. Pamoic acid disodium CAS No. : 6640-22-8 Biological Activity：Pamoic acid disodium is a potent GPR35 agonist with an EC50 value of 79 nM. Pamoic acid disodium induces GPR35 internalization and activates ERK1/2 with EC50 values of 22 nM and 65 nM, respectively. Pamoic acid disodium […]

For research use only. We do not sell to patients. EHP-101 CAS No. : 1818428-24-8 Biological Activity：EHP-101 (VCE-004.8) is an orally active, specific PPARγ and CB2 receptor dual agonist. EHP-101 inhibits prolyl-hydroxylases (PHDs) and activates the HIF pathway. EHP-101, a semi-synthetic multitarget cannabinoquinoid, has potent anti-inflammatory activity. EHP-101 attenuates adipogenesis and prevents diet-induced obesity[2]. Research […]

For research use only. We do not sell to patients. AZD7325 CAS No. : 942437-37-8 Biological Activity：AZD7325 is a potent and orally active partial selective PAM of GABAAα2 and Aα3 receptor (Ki=0.3 and 1.3 nM, respectively), and has less antagonistic efficacy at the Aα1 and Aα5 receptor subtypes[4]. AZD7325 is a moderate CYP1A2 and a potent CYP3A4 inducer in vitro[2]. AZD7325 […]

For research use only. We do not sell to patients. Rilmenidine phosphate CAS No. : 85409-38-7 Biological Activity：Rilmenidine phosphate, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine phosphate is an alpha 2-adrenoceptor agonist. Rilmenidine phosphate induces autophagy. Rilmenidine phosphate acts both centrally by reducing sympathetic overactivity and in the […]