Tag: Antagonist

For research use only. We do not sell to patients. Levobetaxolol CAS No. : 93221-48-8 Biological Activity：Levobetaxolol is a potent and high affinity β-adrenergic antagonist with IC50 values of 33.2, 2970, 709 nM for guinea pig atrial β1, tracheal β2 and rat colonic β3 receptors, respectively. Levobetaxolol reduces IOP (intraocular pressure). Levobetaxolol exhibits a micromolar […]

For research use only. We do not sell to patients. Yohimbine CAS No. : 146-48-5 Biological Activity：Yohimbine is a potent and relatively nonselective alpha 2-adrenergic receptor (AR) antagonist, with IC50 of 0.6 μM. IC50 value: 0.6 uM [1] Target: alpha 2-adrenergic receptor in vitro: Yohimbine inhibits alpha2-receptor antagonist with Ki of 1.05 nM, 1.19 nM, […]

For research use only. We do not sell to patients. Calcium-Sensing Receptor Antagonists I CAS No. : 478963-79-0 Biological Activity：Calcium-Sensing Receptor Antagonists I is an antagonist of calcium-sensing parathyroid hormone receptors. Research Area：Others Targets：CaSR Related Screening Libraries:Covalent Screening Library Plus;Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Covalent Screening Library; Related Small Molecules:Calhex 231 hydrochloride;SB-423562;Ligustroflavone;NPS 2390;AC-265347;GSK3004774;Etelcalcetide hydrochloride;Gadolinium […]

For research use only. We do not sell to patients. Amifampridine phosphate CAS No. : 446254-47-3 Biological Activity：Amifampridine (3,4-Diaminopyridine) phosphate is an orally active, potent and cell permeable voltage-gated potassium (Kv) channel blocker (PCB). Amifampridine phosphate is efficacy in the reversal of BoNT/A (HY-P79153) intoxication. Amifampridine phosphate increases transmitter release from neuromuscular junctions (NMJs). Amifampridine […]

For research use only. We do not sell to patients. (R)-Elagolix CAS No. : 834153-87-6 Biological Activity：Elagolix is a highly potent, selective, orally-active, short-duration, non-peptide antagonist of the gonadotropin-releasing hormone receptor (GnRHR) (KD = 54 pM). Target: GnRH in vitro: Elagolix is a short-acting, nonpeptide, GnRH antagonist, administered orally, that unlike injectable depot GnRH agonists […]

For research use only. We do not sell to patients. Giredestrant CAS No. : 1953133-47-5 Biological Activity：Giredestrant (GDC-9545), a non-steroidal estrogen receptor (ER) ligand, is an orally active and selective ER antagonist. Giredestrant potently competes with Estradiol for binding and induces a conformational change within the ER ligand binding domain. Giredestrant has anti-tumor activity. Research […]

For research use only. We do not sell to patients. Giredestrant tartrate CAS No. : 2407529-33-1 Biological Activity：Giredestrant tartrate (GDC-9545 tartrate), a non-steroidal ER ligand, is an orally active and selective estrogen receptor (ER) antagonist. Giredestrant tartrate potently competes with estradiol for binding and induces a conformational change within the ER ligand binding domain. Anti-tumor […]

For research use only. We do not sell to patients. Fesoterodine CAS No. : 286930-02-7 Biological Activity：Fesoterodine is an orally active, nonsubtype selective, competitive muscarinic receptor (mAChR) antagonist with pKi values of 8.0, 7.7, 7.4, 7.3, 7.5 for M1, M2, M3, M4, M5 receptors, respectively. Fesoterodine is used for the overactive bladder (OAB)[2]. Research Area：Metabolic […]

For research use only. We do not sell to patients. ML-193 CAS No. : 713121-80-3 Biological Activity：ML-193 (CID 1261822) is a potent and selective antagonist of GPR55, with an IC50 of 221 nM. ML-193 shows more than 27-fold selectivity for GPR55 over GPR35, CB1 and CB2. ML-193 can improve the motor and the sensorimotor deficits […]

For research use only. We do not sell to patients. Tripelennamine CAS No. : 91-81-6 Biological Activity：Tripelennamine, an ethylenediamine derivative, is a potent histamine H1-receptor antagonist. Tripelennamine lessens the allergic response of the organism caused by histamine. Tripelennamine can be used for the research of rhinitis, conjunctivitis, and allergic and anaphylactic reactions[2][3]. Research Area：Endocrinology|Inflammation/Immunology Targets：Histamine […]