Tag: Antagonist

For research use only. We do not sell to patients. PACAP (6-38), human, ovine, rat CAS No. : 143748-18-9 Biological Activity：PACAP (6-38), human, ovine, rat is a potent PACAP receptor antagonist with IC50s of 30, 600, and 40 nM for PACAP type I receptor, PACAP type II receptor VIP1, and PACAP type II receptor VIP2, […]

For research use only. We do not sell to patients. GW-1100 CAS No. : 306974-70-9 Biological Activity：GW-1100 is a selective GPR40 antagonist with a pIC50 of 6.9. Research Area：Metabolic Disease Targets：Free Fatty Acid Receptor Related Screening Libraries:Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Human Metabolite Library; Related Small Molecules:Grifolic acid;Ginsenoside Rb2;AP5;GPR40 Activator 1;AM-1638;DC260126;TUG-770;LY2881835;FFA1 agonist-1;GPR120 Agonist 3;AS2034178 […]

For research use only. We do not sell to patients. Gefapixant citrate CAS No. : 2310299-91-1 Biological Activity：Gefapixant citrate is an orally active and potent purinergic P2X3 receptor (P2X3R) antagonist, with IC50 values of ~30 nM versus recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors. Gefapixant citrate can be used for the research […]

For research use only. We do not sell to patients. RORγt inverse agonist 30 CAS No. : 1445901-41-6 Biological Activity：RORγt inverse agonist 30 (Compound 1) is a potent RORγt inverse agonist with the IC50 of 46 nM. Targeting the nuclear receptor RORγt is effective in autoimmune disorders. Research Area：Inflammation/Immunology Targets：ROR Related Small Molecules:RORγt inhibitor 1;GNE-6468;SR3335;GNE-0946;RORγt […]

For research use only. We do not sell to patients. (S)-MCPG CAS No. : 150145-89-4 Biological Activity：(S)-MCPG ((+)-MCPG) is a potent group I/II metabotropic glutamate receptor (mGluRs) antagonist and the active isomer of (RS)-MCPG (HY-100371). (S)-MCPG can be used for the study of the function of mGluRs in spatial learning[2]. Research Area：Neurological Disease Targets：mGluR Related […]

For research use only. We do not sell to patients. ARC 239 dihydrochloride CAS No. : 55974-42-0 Biological Activity：ARC 239 dihydrochloride is a selective α2B/2C adrenoceptor antagonist (pKd values are 5.95, 7.41 and 7.56 at α2A, α2B, and α2C receptors respectively). ARC 239 dihydrochloride binds to CHO cell membranes expressing human recombinant a2A-, a2B- or […]

For research use only. We do not sell to patients. Hydroxy ziprasidone CAS No. : 884305-08-2 Biological Activity：Hydroxy ziprasidone is an impurity of Ziprasidone. Ziprasidone, an antipsychotic agent, is a combined 5-HT (serotonin) and dopamine receptor antagonist[2]. Research Area：Neurological Disease Targets：Dopamine Receptor|5-HT Receptor Related Small Molecules:F 13714;Alizapride hydrochloride;Thioproperazine;Mosapride-d5;Bromopride-d3;Nuciferine;Glaucine;Renzapride;SB-277011 dihydrochloride;LY 344864 racemate;Harmine hydrochloride;MIF-1 TFA;Valerenic acid;Arotinolol;Sulpiride;(Rac)-Razpipadon;Melitracen-d6 hydrochloride;Clebopride […]

For research use only. We do not sell to patients. Talnetant hydrochloride CAS No. : 204519-66-4 Biological Activity：Talnetant (SB 223412) hydrochloride is a selective, competitive, brain-permeable NK3 receptor antagonist with a Ki of 1.4 nM in hNK-3-CHO cells. Talnetant hydrochloride is 100-fold more selective for hNK-3 relative to the hNK-2 receptor and has no affinity […]

For research use only. We do not sell to patients. Diltiazem hydrochloride CAS No. : 33286-22-5 Biological Activity：Diltiazem hydrochloride is a Ca2+ influx inhibitor (slow channel blocker or calcium antagonist). Research Area：Cardiovascular Disease Targets：Calcium Channel Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Membrane Transporter/Ion Channel Compound Library;Neuronal […]

For research use only. We do not sell to patients. Pranlukast-d4 CAS No. : 2713172-43-9 Biological Activity：Pranlukast-d4 is deuterium labeled Pranlukast. Pranlukast is a highly potent, selective and competitive antagonist of peptide leukotrienes. Pranlukast inhibits [3H]LTE4, [3H]LTD4, and [3H]LTC4 bindings to lung membranes with Kis of 0.63±0.11, 0.99±0.19, and 5640±680 nM, respectively. Research Area：Inflammation/Immunology Targets：Leukotriene […]