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(R)-Elagolix

CAS No. : 834153-87-6

Biological Activity：Elagolix is a highly potent, selective, orally-active, short-duration, non-peptide antagonist of the gonadotropin-releasing hormone receptor (GnRHR) (KD = 54 pM).
Target: GnRH
in vitro: Elagolix is a short-acting, nonpeptide, GnRH antagonist, administered orally, that unlike injectable depot GnRH agonists and antagonists, produces a dose-dependent suppression of ovarian estrogen production, that is, from partial suppression at lower doses to full suppression at higher doses. Elagolix is regarded as the frontrunner of a new class of GnRH inhibitors that have been denoted as second-generation, due to their non-peptide nature and oral bioavailability.

Research Area：Cancer|Endocrinology

Targets：GnRH Receptor

Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;GPCR/G Protein Compound Library;FDA-Approved Drug Library;Anti-Cancer Compound Library;Drug Repurposing Compound Library;Endocrinology Compound Library;Anti-COVID-19 Compound Library;Orally Active Compound Library;FDA Approved & Pharmacopeial Drug Library;Drug-Induced Liver Injury (DILI) Compound Library;FDA-Approved Anticancer Drug Library;Human Metabolite Library;

Related Small Molecules:Linzagolix;Relugolix-d6;[D-Ala6]-LH-RH;Relugolix;Teverelix;Alarelin Acetate;[D-Leu6, Val7]-LH-RH (1-9) Ethyl Amide;Kisspeptin 13;opigolix;sGnRH-A;Lecirelin;GnRH-R antagonist 1;Ozarelix;LH-RH (7-10);BAY-298;Acyline;GnRH-I;Lamprey LH-RH I;BAY-784;BAY 1214784;GnRH antagonist 2;[D-Lys6]-LH-RH

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