Tag: Inhibitor|Modulator

For research use only. We do not sell to patients. Bryostatin 1 CAS No. : 83314-01-6 Biological Activity：Bryostatin 1 is a natural macrolide isolated from the bryozoan Bugula neritina and is a potent and central nervous system (CNS)-permeable PKC modulator. Bryostatin 1 binds to the isolated C1 domain of Munc13-1 and the full-length Munc13-1 protein […]

For research use only. We do not sell to patients. Fulvene-5 CAS No. : 1075723-01-1 Biological Activity：Fulvene-5 is a potent NADPH oxidase 4 (NOX4) inhibitor with antioxidant properties. Fulvene-5 is a reactive oxygen species (ROS) modifying agent and a potent radioprotector. Fulvene-5 has antitumor activity[2][3]. Research Area：Cancer Targets：Reactive Oxygen Species|NADPH Oxidase Related Small Molecules:D-α-Hydroxyglutaric acid […]

For research use only. We do not sell to patients. BX795 CAS No. : 702675-74-9 Biological Activity：BX795 is a potent and selective inhibitor of PDK1, with an IC50 of 6 nM. BX795 is also a potent and relatively specific inhibitor of TBK1 and IKKɛ, with an IC50 of 6 and 41 nM, respectively. BX795 blocks […]

For research use only. We do not sell to patients. (E/Z)-Sulindac sulfide CAS No. : 32004-67-4 Biological Activity：(E/Z)-Sulindac sulfide is a potent γ-secretase modulator (GSM). (E/Z)-Sulindac sulfide selectively reduces Aβ42 production in favor of shorter Aβ species. (E/Z)-Sulindac sulfide can be used for researching Alzheimer’s disease. Research Area：Neurological Disease Targets：γ-secretase|Amyloid-β Related Small Molecules:β-Amyloid (13-27);γ-Secretase modulator […]

For research use only. We do not sell to patients. Sulindac sodium CAS No. : 63804-15-9 Biological Activity：Sulindac (MK-231) is an orally active nonsteroidal anti-inflammatory agent. Sulindac also is an immunomodulatory agent. Sulindac can be used for the research of arthritis of the spine, gouty arthritis and kinds of cancer including colorectal cancer (CRC) and […]

For research use only. We do not sell to patients. Avanafil dibenzenesulfonate CAS No. : 330784-48-0 Biological Activity：Avanafil (TA-1790) dibenzenesulfonate is a potent and selective phosphodiesterase-5 (PDE-5) inhibitor with IC50 values of 5.2 nM, 630 nM, 5700 nM, 6200 nM, 12000 nM, 27000 nM, 51000 nM and 53000 nM for PDE-5, PDE-6, PDE-4, PDE-10, PDE-8, […]

For research use only. We do not sell to patients. Vps34-IN-1 CAS No. : 1383716-33-3 Biological Activity：Vps34-IN-1 is an inhibitor of Vps34 extracted from patent WO2012085815A1, compound example 16a, with an IC50 of 4 nM. Vps34-IN-1 modulates autophagy[2]. Research Area：Cancer Targets：Autophagy|PI3K Related Screening Libraries:Covalent Screening Library Plus;Bioactive Compound Library Plus;Kinase Inhibitor Library;PI3K/Akt/mTOR Compound Library;Stem Cell […]