Tag: Inducer|Inhibitor

For research use only. We do not sell to patients. IHMT-TRK-284 CAS No. : 2416844-79-4 Biological Activity：IHMT-TRK-284 (Compound 34) is a potent, orally active type II TRK kinase inhibitor with IC50 values of 10.5, 0.7, and 2.6 nM to TRKA, B, and C respectively. IHMT-TRK-284 displays great selectivity profile in the kinome and good in […]

For research use only. We do not sell to patients. Abacavir monosulfate CAS No. : 216699-07-9 Biological Activity：Abacavir monosulfate is a competitive, orally active nucleoside reverse transcriptase inhibitor. Abacavir monosulfate can inhibits the replication of HIV. Abacavir monosulfate shows anticancer activity in prostate cancer cell lines. Abacavir monosulfate can trespass the blood-brain-barrier and suppresses telomerase […]

For research use only. We do not sell to patients. Licochalcone D CAS No. : 144506-15-0 Biological Activity：Licochalcone D, a flavonoid compound mainly existing in the root of Glycyrrhiza uralensis, is a potent and orally active inhibitor of NF-kappaB (NF-κB) p65. Licochalcone D possesses antioxidant, anti-inflammatory, anti-cancer properties[2]. Research Area：Cancer|Metabolic Disease|Inflammation/Immunology Targets：NF-κB|Reactive Oxygen Species|Apoptosis Related […]

For research use only. We do not sell to patients. T025 CAS No. : 2407433-00-3 Biological Activity：T025 is an orally active and highly potent inhibitor of Cdc2-like kinase (CLKs), with Kd values of 4.8, 0.096, 6.5, 0.61, 0.074, 1.5 and 32 nM for CLK1, CLK2, CLK3, CLK4, DYRK1A, DYRK1B and DYRK2, respectively. T025 induces caspase-3/7-mediated […]

For research use only. We do not sell to patients. Flavopiridol CAS No. : 146426-40-6 Biological Activity：Flavopiridol (Alvocidib) is a broad spectrum and competitive inhibitor of CDKs, inhibiting CDK1, CDK2, CDK4 with IC50s of 30, 170, 100 nM, respectively. Research Area：Cancer Targets：Autophagy|CDK|HIV|Apoptosis Related Screening Libraries:Natural Product-like Compound Library;Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive […]

For research use only. We do not sell to patients. 1A-116 CAS No. : 1430208-73-3 Biological Activity：1A-116, a potent Rac1 inhibitor, is specific for W56 residues, can prevent EGF-induced Rac1 activation and block Rac1-P-Rex1 interaction. 1A-116 can induce apoptosis and inhibit cell proliferation, migration and cycle progression in a concentration-dependent manner. 1A-116 also demonstrates a […]

For research use only. We do not sell to patients. FLT3-IN-13 Biological Activity：FLT3-IN-13 (compound 20) is a potent and effective antileukemic topoisomerase II and FLT3 dual inhibitor with IC50 values of 2.26 μM and 2.26 μM, respectively. FLT3-IN-13 arrests cell cycle at G2/M phase and induce apoptosis. FLT3-IN-13 has anticytotoxic activity, particularly against leukemia. Research […]

For research use only. We do not sell to patients. PS-1145 CAS No. : 431898-65-6 Biological Activity：PS-1145 is an IκB kinase (IKK) inhibitor with an IC50 of 88 nM. Research Area：Cancer Targets：IKK|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Immunology/Inflammation Compound Library;Kinase Inhibitor Library;NF-κB Signaling Compound Library;Stem Cell Signaling Compound Library;Anti-Cancer Compound Library;Anti-Aging Compound Library;Differentiation […]

For research use only. We do not sell to patients. PCAF-IN-2 CAS No. : 56173-05-8 Biological Activity：PCAF-IN-2 (compound 17) is a potent PCAF inhibitor with an IC50 value of 5.31 µM. PCAF-IN-2 shows anti-tumour activity. CAF-IN-2 induces apoptosis and arrest the cell cycle at the G2/M phase. Research Area：Cancer Targets：Apoptosis|Histone Acetyltransferase Related Small Molecules:Physalin A;Bomedemstat […]

For research use only. We do not sell to patients. Erlotinib Hydrochloride CAS No. : 183319-69-9 Biological Activity：Erlotinib Hydrochloride (CP-358774 Hydrochloride) inhibits purified EGFR kinase with an IC50 of 2 nM. Research Area：Cancer Targets：EGFR|Autophagy Related Screening Libraries:Covalent Screening Library Plus;Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;JAK/STAT […]