Tag: Inducer|Inhibitor

For research use only. We do not sell to patients. Ponatinib-d8 CAS No. : 1562993-37-6 Biological Activity：Ponatinib D8 (AP24534 D8) is a deuterium labeled Ponatinib. Ponatinib (AP24534) is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, […]

For research use only. We do not sell to patients. Genistein CAS No. : 446-72-0 Biological Activity：Genistein, a soy isoflavone, is a multiple tyrosine kinases (e.g., EGFR) inhibitor which acts as a chemotherapeutic agent against different types of cancer, mainly by altering apoptosis, the cell cycle, and angiogenesis and inhibiting metastasis. Research Area：Cancer Targets：EGFR|Autophagy|Endogenous Metabolite|Apoptosis […]

For research use only. We do not sell to patients. Methotrexate-d3 CAS No. : 432545-63-6 Biological Activity：Methotrexate-d3 (Amethopterin-d3) is the deuterium labeled Methotrexate. Methotrexate (Amethopterin), an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate, also an immunosuppressant and antineoplastic agent, […]

For research use only. We do not sell to patients. ARN5187 trihydrochloride CAS No. : 1700693-96-4 Biological Activity：ARN5187 trihydrochloride is a lysosomotropic REV-ERBβ ligand with a dual inhibitory activity toward REV-ERB-mediated transcriptional regulation and autophagy. ARN5187 trihydrochloride shows lysosomotropic potency and cytotoxicity. ARN5187 trihydrochloride induces apoptosis[2]. Research Area：Cancer Targets：Autophagy|Apoptosis Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;BJE6-106;Dinaciclib;Ecteinascidin […]

For research use only. We do not sell to patients. Dacarbazine-d6 CAS No. : 1185241-28-4 Biological Activity：Dacarbazine-d6 (Imidazole Carboxamide-d6) is the deuterium labeled Dacarbazine. Dacarbazine(DTIC-Dome; DTIC) is an antineoplastic agent. It has significant activity against melanomas. Research Area：Cancer Targets：Nucleoside Antimetabolite/Analog|Apoptosis Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;m7GpppCpG;BJE6-106;7-TFA-ap-7-Deaza-dA;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;Xevinapant;Mangiferin;Cambinol;Antioxidant agent-5;Apoptosis inducer 9;Bafetinib Trending products：Recombinant […]

For research use only. We do not sell to patients. STAT3-IN-1 CAS No. : 2059952-75-7 Biological Activity：STAT3-IN-1 (compound 7d) is an excellent, selective and orally active STAT3 inhibitor, with IC50 values of 1.82 μM and 2.14 μM in HT29 and MDA-MB 231 cells, respectively. STAT3-IN-1 (compound 7d) induces tumor cells apoptosis. Research Area：Cancer Targets：STAT|Apoptosis Related […]

For research use only. We do not sell to patients. MS1943 CAS No. : 2225938-17-8 Biological Activity：MS1943 is a first-in-class, orally bioavailable EZH2 selective degrader, with an IC50 of 120 nM. MS1943 significantly reduces EZH2 protein levels in numerous triple-negative breast cancer (TNBC) and other cancer and noncancerous cell lines. MS1943 effectively blocks proliferation of […]

For research use only. We do not sell to patients. Oenothein B CAS No. : 104987-36-2 Biological Activity：Oenothein B is a dimeric macrocyclic ellagitannin and has widely pharmacological activities, including antioxidant, anti-inflammatory, antifungal, anti-HCV, and antitumor properties. Oenothein B is a potent and specific inhibitor of poly(ADP-ribose) glycohydrolase[2]. Research Area：Cancer|Infection|Inflammation/Immunology Targets：Fungal|HCV|Bacterial|Apoptosis Related Small Molecules:Antifungal agent […]

For research use only. We do not sell to patients. Ciprofloxacin CAS No. : 85721-33-1 Biological Activity：Ciprofloxacin (Bay-09867) is a potent, orally active topoisomerase IV inhibitor. Ciprofloxacin induces mitochondrial DNA and nuclear DNA damage and lead to mitochondrial dysfunction, ROS production. Ciprofloxacin has anti-proliferative activity and induces apoptosis. Ciprofloxacin is a fluoroquinolone antibiotic, exhibiting potent […]

For research use only. We do not sell to patients. PI-103-d8 Biological Activity：PI-103-d8 is the deuterium labeled PI-103. PI-103 is a potent PI3K and mTOR inhibitor with IC50s of 8 nM, 88 nM, 48 nM, 150 nM, 20 nM, and 83 nM for p110α, p110β, p110δ, p110γ, mTORC1, and mTORC2. PI-103 also inhibits DNA-PK with […]