Tag: Inducer|Inhibitor

For research use only. We do not sell to patients. Cyclovirobuxine D CAS No. : 860-79-7 Biological Activity：Cyclovirobuxine D (CVB-D) is the main active component of the traditional Chinese medicine Buxus microphylla. Cyclovirobuxine D induces autophagy and attenuates the phosphorylation of Akt and mTOR. Cyclovirobuxine D inhibits cell proliferation of gastric cancer cells through suppression […]

For research use only. We do not sell to patients. Aliskiren hydrochloride CAS No. : 173399-03-6 Biological Activity：Aliskiren (CGP 60536; CGP60536B; SPP 100) hydrochloride is an orally active and selective renin inhibitor, with IC50 of 1.5 nM. Aliskiren hydrochloride can be used for the research of hypertension, cardiovascular diseases and cancer cachexia–[4]. Research Area：Cancer|Cardiovascular Disease […]

For research use only. We do not sell to patients. AZ 628 CAS No. : 878739-06-1 Biological Activity：AZ 628 is a pan-Raf kinase inhibitor with IC50s of 105, 34 and 29 nM for B-Raf, B-RafV600E, and c-Raf-1, respectively. Research Area：Cancer Targets：Raf|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Immunology/Inflammation Compound Library;Kinase Inhibitor Library;MAPK Compound Library;Anti-Cancer […]

For research use only. We do not sell to patients. Cytarabine-d2 CAS No. : 40632-26-6 Biological Activity：Cytarabine-d2 is the deuterium labeled Cytarabine. Cytarabine, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC50 of 16 nM. Cytarabine has antiviral effects against HSV[2]. Research Area：Cancer|Infection Targets：HSV|Nucleoside […]

For research use only. We do not sell to patients. Colistin sulfate CAS No. : 1264-72-8 Biological Activity：Colistin sulfate is a polypeptide antibiotic which inhibits gram-negative bacteria by binding to lipopolysaccharides and phospholipids in the outer cell membrane of gram-negative bacteria. Research Area：Infection Targets：Autophagy|Bacterial|Antibiotic Related Screening Libraries:Natural Product Library Plus;Drug Repurposing Compound Library Plus;FDA-Approved Drug […]

For research use only. We do not sell to patients. BIX-01294 trihydrochloride CAS No. : 1392399-03-9 Biological Activity：BIX-01294 trihydrochloride is a reversible and highly selective G9a and GLP Histone Methyltransferase inhibitor, with IC50s of of 1.7 μM and 0.9 μM, respectively. BIX-01294 trihydrochloride inhibits G9a/GLP by competing for binding with the amino acids N-terminal of […]

For research use only. We do not sell to patients. Samuraciclib hydrochloride hydrate Biological Activity：Samuraciclib (CT7001) hydrochloride hydrate is a potent, selective, ATP-competitive and orally active CDK7 inhibitor, with an IC50 of 41 nM. Samuraciclib hydrochloride hydrate displays 45-, 15-, 230- and 30-fold selectivity over CDK1, CDK2 (IC50 of 578 nM), CDK5 and CDK9, respectively. […]

For research use only. We do not sell to patients. Hypericin CAS No. : 548-04-9 Biological Activity：Hypericin is a naturally occurring substance found in Hyperlcurn perforatum L. Hypericin is an inhibitor of PKC (protein kinase C), MAO (monoaminoxidase), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450). Hypericin shows antitumor, antiviral, antidepressive activities, and can induce […]

For research use only. We do not sell to patients. KRAS G12D inhibitor 14 CAS No. : 2765254-39-3 Biological Activity：KRAS G12D inhibitor 14 is a potent KRAS G12D inhibitor with a KD of 33 nM for binding to KRAS G12D protein. KRAS G12D inhibitor 14 decreases the active form of KRAS G12D (KRAS G12D-GTP) but […]

For research use only. We do not sell to patients. Cidofovir dihydrate CAS No. : 149394-66-1 Biological Activity：Cidofovir (GS 0504; HPMPC; (S)-HPMPC) dihydrate is an acyclic monophosphate nucleotide analogue and CMV inhibitor with antiviral activity. Cidofovir dihydrate inhibits cytomegalovirus (CMV) replication by selectively inhibiting viral DNA polymerase. Cidofovir dihydrate induces apoptosis and can be used […]