Tag: Antagonist|Inhibitor

For research use only. We do not sell to patients. Wf-516 CAS No. : 310392-94-0 Biological Activity：Wf-516 is an inhibitor of 5-HT reuptake, and an antagonist of 5-HT1A and 5-HT2A receptors, with Ki of 5 nM and 40 nM for 5-HT1A receptor and 5-HT2A receptor in humans, respectively, and has potent antidepressant activity. Research Area：Neurological […]

For research use only. We do not sell to patients. SM-6586 CAS No. : 103898-38-0 Biological Activity：SM-6586 is a calcium channel antagonist and inhibitor of Na+/H+ and Na+/Ca2+ exchange transport, potentially for the treatment of cerebrovasular diseases and hypertension. Research Area：Cardiovascular Disease Targets：Calcium Channel|Na+/Ca2+ Exchanger Related Small Molecules:Benidipine hydrochloride;CaV1.3 antagonist-1;14-Deoxyandrographolide;(Rac)-MEM 1003;SN 6;Glaucine;Efonidipine hydrochloride monoethanolate;L-Ascorbic acid […]

For research use only. We do not sell to patients. LY 178002 CAS No. : 107889-32-7 Biological Activity：LY 178002 is a potent inhibitor of 5-lipoxygenase (5-LPO), phospholipase A2, with IC50 of 0.6 μM for 5-lipoxygenase, inhibits cellular production of LTB4 by human polymorphonuclear leukocytes, and shows relatively weak inhibition on cyclooxygenase. Research Area：Inflammation/Immunology Targets：Lipoxygenase|Phospholipase|COX Related […]

For research use only. We do not sell to patients. NPS 2390 CAS No. : 226878-01-9 Biological Activity：NPS 2390 is a noncompetitive antagonist of mGluR1 and mGluR5. NPS 2390 is also a potent CaSR (calcium-sensing receptor) inhibitor[2][3]. Research Area：Neurological Disease|Cardiovascular Disease Targets：CaSR|mGluR Related Small Molecules:LY3020371 hydrochloride;ZJ43;FPTQ;(S)-MCPG;Calcium-Sensing Receptor Antagonists I;mGluR2 modulator 1;VU6010572;Mavoglurant racemate;DFMTI;JNJ16259685;Auglurant;FITM;(-)-Camphoric acid;LY367385 hydrochloride;Cinnabarinic acid;LY379268;AZD […]

For research use only. We do not sell to patients. N-Arachidonoylserotonin CAS No. : 187947-37-1 Biological Activity：N-Arachidonoylserotonin (Arachidonyl serotonin; AA-5-HT) is a potent fatty acid amide hydrolase (FAAH) inhibitor with an IC50 value of 1~12 µM. N-Arachidonoylserotonin acts also as an antagonist of transient receptor potential vanilloid-type 1 (TRPV1) channels (IC50=70~100 nM). N-Arachidonoylserotonin is analgesic […]

For research use only. We do not sell to patients. Furosemide CAS No. : 54-31-9 Biological Activity：Furosemide is a potent and orally active inhibitor of Na+/K+/2Cl– (NKCC) cotransporter, NKCC1 and NKCC2. Furosemide is also a GABAA receptors antagonist and displays 100-fold selectivity for α6-containing receptors than α1-containing receptors. Furosemide acts as a loop diuretic and used for the study of […]

For research use only. We do not sell to patients. SANT-1 CAS No. : 304909-07-7 Biological Activity：SANT-1, a potent Smo antagonist, inhibits Hedgehog signaling. SANT-1 shows IC50s of 20 nM and 30 nM in Shh-LIGHT2 and SmoA1-LIGHT2 assay, respectively. Research Area：Cancer Targets：Smo|Hedgehog Related Screening Libraries:Bioactive Compound Library Plus;Stem Cell Signaling Compound Library;Wnt/Hedgehog/Notch Compound Library;Anti-Cancer Compound […]

For research use only. We do not sell to patients. (Rac)-Nebivolol CAS No. : 99200-09-6 Biological Activity：(Rac)-Nebivolol ((Rac)-R 065824) is a racemic isomer of Nebivolol. Nebivolol is a selective β1-adrenergic receptor antagonist with an IC50 value of 0.8 nM. Nebivolol can prevent up-regulation of Nox2/NADPH oxidase and lipoperoxidation in the early stages of ethanol-induced cardiac […]

For research use only. We do not sell to patients. Vicriviroc maleate CAS No. : 599179-03-0 Biological Activity：Vicriviroc maleate (SCH-417690 maleate; SCH-D maleate) is a potent, selective, oral bioavailable and CNS penetrated antagonist of CCR5, with a Ki of 2.5 nM, and also inhibits HIV-1 in PBMC cells, with IC90s of 3.3 nM (JrFL), 2.8 […]

For research use only. We do not sell to patients. 3,3′-Diindolylmethane CAS No. : 1968-05-4 Biological Activity：3,3′-Diindolylmethane is a strong, pure androgen receptor (AR) antagonist. Research Area：Cancer Targets：Androgen Receptor|Autophagy Related Screening Libraries:Natural Product Library Plus;Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Natural Product Library;Anti-Cancer Compound Library;Clinical Compound Library;Autophagy Compound Library;Drug Repurposing Compound […]