Tag: Antagonist|Inhibitor

For research use only. We do not sell to patients. Methicillin CAS No. : 61-32-5 Biological Activity：Methicillin is a narrow-spectrum β-lactam antibiotic, acts by inhibiting penicillin-binding proteins (PBPs). Methicillin is active against Staphylococcus aureus and Staphylococcus epidermidis that are resistant to other penicillins.Methicillin can be used for the research of skin infections, osteomyelitis, and endocarditis. […]

For research use only. We do not sell to patients. Furosemide sodium CAS No. : 41733-55-5 Biological Activity：Furosemide sodium is a potent and orally active inhibitor of Na+/K+/2Cl– (NKCC) cotransporter, NKCC1 and NKCC2. Furosemide sodium is also a GABAA receptors antagonist and displays 100-fold selectivity for α6-containing receptors than α1-containing receptors. Furosemide sodium acts as a loop diuretic and used […]

For research use only. We do not sell to patients. Bisindolylmaleimide X hydrochloride CAS No. : 145317-11-9 Biological Activity：Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride) is a potent and selective protein kinase C (PKC) inhibitor. Bisindolylmaleimide X hydrochloride is a potent cyclin-dependent kinase 2 (CDK2) antagonist with an IC50 of 200 nM. Research Area：Cardiovascular Disease Targets：CDK|PKC Related […]

For research use only. We do not sell to patients. Clemizole hydrochloride CAS No. : 1163-36-6 Biological Activity：Clemizole hydrochloride is an H1 histamine receptor antagonist, is found to substantially inhibit HCV replication. Clemizole hydrochloride is an inhibitor of TRPC5 channel. The IC50 of Clemizole hydrochloride for RNA binding by NS4B is 24 nM, whereas its […]

For research use only. We do not sell to patients. Lotilaner CAS No. : 1369852-71-0 Biological Activity：Lotilaner is a parasiticide, acts as a potent non-competitive antagonist of insects GABACl receptors, with an IC50 of 23.84 nM for Drosophila melanogaster GABA receptor. No effect on a dog GABAA receptor. Research Area：Infection Targets：Parasite|GABA Receptor Related Screening Libraries:Bioactive […]

For research use only. We do not sell to patients. Metoprolol tartrate CAS No. : 56392-17-7 Biological Activity：Metoprolol tartrate is an orally active, selective β1-adrenoceptor antagonist. Metoprolol tartrate shows anti-inflammation, antitumor and anti-angiogenic properties[2][3]. Research Area：Cancer|Infection|Endocrinology|Cardiovascular Disease Targets：Adrenergic Receptor|Apoptosis Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;Todralazine;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;ARC 239 dihydrochloride;Xevinapant;Mangiferin;Cambinol;Antioxidant agent-5;Apoptosis inducer 9 Trending […]

For research use only. We do not sell to patients. Asenapine-d7 Biological Activity：Asenapine-d7 (Org 5222-d7) is the deuterium labeled Asenapine. Asenapine (Org 5222), an atypical antipsychotic, is an antagonist of serotonin receptors (pKi: 8.4-10.5), adrenoceptors (pKi: 8.9-9.5), dopamine receptors (pKi: 8.9-9.4) and histamine receptors (pKi: 8.2-9.0). Asenapine can be used in the research of schizophrenia […]

For research use only. We do not sell to patients. Cyclopamine CAS No. : 4449-51-8 Biological Activity：Cyclopamine is a Hedgehog (Hh) pathway antagonist with an IC50 of 46 nM in the Hh cell assay. Cyclopamine is also a selective Smo inhibitor. Research Area：Cancer Targets：Smo|Hedgehog|Endogenous Metabolite Related Screening Libraries:Covalent Screening Library Plus;Natural Product Library Plus;Bioactive Compound […]

For research use only. We do not sell to patients. AMD 3465 hexahydrobromide CAS No. : 185991-07-5 Biological Activity：AMD 3465 hexahydrobromide (GENZ-644494 hexahydrobromide) is a potent antagonist of CXCR4, inhibits binding of 12G5 mAb and CXCL12AF647 to CXCR4, with IC50s of 0.75 nM and 18 nM in SupT1 cells; AMD 3465 also potently inhibits the […]

For research use only. We do not sell to patients. Risperidone CAS No. : 106266-06-2 Biological Activity：Risperidone is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively. Research Area：Neurological Disease Targets：Dopamine Receptor|5-HT Receptor|P-glycoprotein Related Screening Libraries:Drug Repurposing Compound […]