Tag: Activator|Inhibitor

For research use only. We do not sell to patients. Purvalanol A CAS No. : 212844-53-6 Biological Activity：Purvalanol A is a potent CDK inhibitor, which inhibits cdc2-cyclin B, cdk2-cyclin A, cdk2-cyclin E, cdk4-cyclin D1, and cdk5-p35 with IC50s of 4, 70, 35, 850, 75 nM, resepctively. Research Area：Cancer Targets：Autophagy|CDK|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis […]

For research use only. We do not sell to patients. PKCβ inhibitor 1 CAS No. : 257879-35-9 Biological Activity：PKCβ inhibitor 1 is a potent, ATP-competitive, and selective PKCβ inhibitor with IC50s of 21 and 5 nM for human PKCβ1 and PKCβ2, respectively. PKCβ inhibitor 1 exhibits selectivity of more than 60-fold in favor of PKCβ2 […]

For research use only. We do not sell to patients. Rosuvastatin D3 CAS No. : 1133429-16-9 Biological Activity：Rosuvastatin D3 (ZD 4522 D3) is a deuterium labeled Rosuvastatin. Rosuvastatin (ZD 4522) is a competitive HMG-CoA reductase inhibitor with an IC50 of 11 nM. Rosuvastatin potently blocks human ether-a-go-go related gene (hERG) current with an IC50 of […]

For research use only. We do not sell to patients. Oltipraz CAS No. : 64224-21-1 Biological Activity：Oltipraz has an inhibitory effect on HIF-1α activation in a time-dependent manner, completely abrogating HIF-1α induction at ≥10 μM concentrations, the IC50 of Oltipraz for HIF-1α inhibition is 10 μM. Oltipraz is a potent Nrf2 activator. Research Area：Cancer Targets：Parasite|Keap1-Nrf2|HIF/HIF […]

For research use only. We do not sell to patients. PD-1/PD-L1-IN-10 CAS No. : 2487550-41-2 Biological Activity：PD-1/PD-L1-IN-10 (compound B2) is an orally active PD-1/PD-L1 inhibitor (IC50 of 2.7 nM) with potent anticancer efficacy. Research Area：Cancer Targets：PD-1/PD-L1|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Immunology/Inflammation Compound Library;Anti-Cancer Compound Library;Small Molecule Immuno-Oncology Compound Library;Anti-Breast Cancer Compound Library;Anti-Lung […]

For research use only. We do not sell to patients. Ixazomib citrate CAS No. : 1239908-20-3 Biological Activity：Ixazomib citrate (MLN9708) is a reversible inhibitor of the chymotrypsin-like proteolytic β5 site of the 20S proteasome with an IC50 of 3.4 nM and a Ki of 0.93 nM. Research Area：Cancer Targets：Autophagy|Proteasome Related Screening Libraries:Drug Repurposing Compound Library […]

For research use only. We do not sell to patients. LQZ-7F CAS No. : 354543-09-2 Biological Activity：LQZ-7F, a survivin dimerization inhibitor, induces spontaneous apoptosis and synergizes with Docetaxel in prostate cancer cells. LQZ-7F dose-dependently inhibits survival of both PC-3 and C4-2 cells with IC50s of 2.99 and 2.47 µM, respectively. Research Area：Cancer Targets：Survivin|Apoptosis Related Small […]

For research use only. We do not sell to patients. Musk ketone CAS No. : 81-14-1 Biological Activity：Musk ketone (MK) is a widely used artificial fragrance. Musk ketone shows mutagenic and comutagenic effects in Hep G2 cells and induces neural stem cell proliferation and differentiation in cerebral ischemia via activation of the PI3K/Akt signaling pathway. […]

For research use only. We do not sell to patients. Perifosine CAS No. : 157716-52-4 Biological Activity：Perifosine is an oral Akt inhibitor which inhibits proliferation of different tumor cell lines with IC50s of 0.6-8.9 μM. Research Area：Cancer Targets：Akt|Autophagy|Apoptosis Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Apoptosis Compound Library;Kinase Inhibitor Library;PI3K/Akt/mTOR […]

For research use only. We do not sell to patients. Anticancer agent 69 Biological Activity：Anticancer agent 69 (Compound 34), a potent and selective anticancer agent , potently and selectively inhibits human prostate cancer cell line PC3 (IC50=26 nM). Anticancer agent 69 increases ROS level, down-regulates EGFR and induces apoptosis. Research Area：Cancer Targets：EGFR|Reactive Oxygen Species|Apoptosis Related Small Molecules:D-α-Hydroxyglutaric acid disodium;Physalin A;Bomedemstat ditosylate;Chitoheptaose heptahydrochloride;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;NSC81111;N-Acetyl-D-cysteine;BJE6-106;Dinaciclib;pp60 […]