Rosuvastatin D3

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Rosuvastatin D3

CAS No. : 1133429-16-9

Biological Activity:Rosuvastatin D3 (ZD 4522 D3) is a deuterium labeled Rosuvastatin. Rosuvastatin (ZD 4522) is a competitive HMG-CoA reductase inhibitor with an IC50 of 11 nM. Rosuvastatin potently blocks human ether-a-go-go related gene (hERG) current with an IC50 of 195 nM, delayed cardiac repolarization, and thereby prolonged action potential durations (APDs) and corrected QT interval (QTc) intervals[2].

Research Area:Metabolic Disease|Cardiovascular Disease

Targets:Autophagy|Potassium Channel|HMG-CoA Reductase (HMGCR)

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