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CAS No. : 2074702-04-6

Biological Activity:TNF-α-IN-2 is a potent and orally active inhibitor of tumor necrosis factor alpha (TNFα), with an IC50 of 25 nM in the HTRF assay. TNF-α-IN-2 distorts the TNFα trimer upon binding, leading to aberrant signaling when the trimer binds to TNFR1. TNF-α-IN-2 can be used for the research of rheumatoid arthritis.

Research Area:Inflammation/Immunology

Targets:TNF Receptor

Related Screening Libraries:Bioactive Compound Library Plus;

Related Small Molecules:Akt/NF-κB/JNK-IN-1;AX-024;QNZ;Sinulatumolin E;Epobis;Mulberroside A;Sinulatumolin D;PDE4-IN-10;Ginsenoside Rc;TIC10;Teneliximab;Loganic acid 6′-O-β-D-glucoside;VGX-1027;D-Trimannuronic acid;DCVC;Gamma-glutamylcysteine TFA;Varlilumab;Sinulatumolin C;Thunbergol;Roquinimex;Semapimod tetrahydrochloride;GSK2245035;R-7050;Sinensetin-d3;TNF-α (31-45), human TFA;Cynaropicrin

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