Tag: Modulator

For research use only. We do not sell to patients. 6-Methoxy-2-naphthoic acid CAS No. : 2471-70-7 Biological Activity：6-Methoxy-2-naphthoic acid is an NMDA receptor modulator extracted from patent WO 2012019106 A2. Research Area：Neurological Disease Targets：iGluR Related Screening Libraries:Bioactive Compound Library Plus;Membrane Transporter/Ion Channel Compound Library;Neuronal Signaling Compound Library;Fragment Library;Neurotransmitter Receptor Compound Library;FDA Approved & Pharmacopeial Drug […]

For research use only. We do not sell to patients. LY487379-d3 hydrochloride CAS No. : 2732982-35-1 Biological Activity：LY487379-d3 hydrochloride is the deuterium labeled LY487379 hydrochloride. LY487379 hydrochloride is a selective human mGluR2 positive allosteric modulator (PAM). LY487379 hydrochloride potentiates glutamate-stimulated [35S]GTPγS binding with EC50 values of 1.7 μM and >10 μM for mGlu2 and mGlu3 receptors respectively. LY487379 […]

For research use only. We do not sell to patients. Pomalidomide-C3-adavosertib CAS No. : 2414418-49-6 Biological Activity：Pomalidomide-C3-adavosertib is a rapid and selective Wee1 degrader (IC50=3.58 nM). Pomalidomide-C3-adavosertib shows anti-cancer cell proliferation activity, and induces apoptosis. Research Area：Cancer Targets：Wee1 Related Small Molecules:DB0614;LEB-03-153;WEE1-IN-4;LEB-03-145;PD0166285 dihydrochloride;WEE1-IN-3;RSS0680;WEE1-IN-5;LEB-03-146;Adavosertib;PD 407824;LEB-03-144 Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent […]

For research use only. We do not sell to patients. MPM-1 Biological Activity：MPM-1, a marine Eusynstyelamides mimic, is a potent anticancer agent. MPM-1 can rapidly kill cancer cells in vitro by inducing a necrosis-like death. MPM-1 has the ability to induce immunogenic cell death. MPM-1 causes perturbation of autophagy and lysosomal swelling in cancer cells. […]

For research use only. We do not sell to patients. VU0360172 CAS No. : 1310012-12-4 Biological Activity：VU0360172 is a potent and selective mGlu5 receptor positive allosteric modulator with an EC50 value of 16 nM and a Ki of 195 nM, respectively. VU0360172 stimulates polyphosphoinositide (PI) hydrolysis in vivo, which is abrogated in mGlu5 receptors gene […]

For research use only. We do not sell to patients. Sunobinop CAS No. : 1126793-40-5 Biological Activity：Sunobinop (S 117957) is a modulator of the opioid receptor-like orphan receptor (ORL1). Research Area：Neurological Disease Targets：Opioid Receptor Related Small Molecules:ORL1 antagonist 1;Loperamide-d6 N-Oxide;Deltorphin 2 TFA;Nalfurafine;β-Lipotropin (60-65);GSK1521498 free base;Trimebutine-d5 fumarate;Dynorphin B (1-13) (TFA);Dermorphin Analog;β-Endorphin (6-31), human;JTC-801;Valorphin;Corydaline;TAN-452;Matrine;Naloxonazine dihydrochloride;[Leu5]-Enkephalin;Sec-O-Glucosylhamaudol;DPDPE;EST73502;CTOP;β-Endorphin, equine;Tyr-W-MIF-1;Nociceptin (1-13), […]

For research use only. We do not sell to patients. Dazucorilant CAS No. : 1496508-34-9 Biological Activity：Dazucorilant (CORT113176) is a selective and high affinity non-steroidal glucocorticoid receptor (GR) modulator with a Ki value ＜1 nM in vitro. Dazucorilant can be used for the research of neurological disorders[2]. Research Area：Inflammation/Immunology|Neurological Disease Targets：Glucocorticoid Receptor Related Small Molecules:Deflazacort-D5;Glucocorticoid […]

For research use only. We do not sell to patients. NMDA receptor modulator 2 CAS No. : 2758255-05-7 Biological Activity：NMDA receptor modulator 2 (Compound 1) is a potent NMDA receptor modulator. NMDA receptor modulator 2 can be used for neurological disorder research. Research Area：Neurological Disease Targets：iGluR Related Small Molecules:CIQ;Quinolinic acid-d3;1-Aminocyclobutanecarboxylic acid;Glycine-1-13C,15N;ZL006;PYD-106;NMDA-IN-2;JAMI1001A;(S)-Willardiine;Fanapanel;(S)-AMPA;L-Glutamic acid-15N,d5;PDZ1 Domain inhibitor peptide […]

For research use only. We do not sell to patients. Amebucort CAS No. : 83625-35-8 Biological Activity：Amebucort is a synthetic glucocorticoid corticosteroid, may used for the research of inflammatory disorders. Research Area：Inflammation/Immunology|Endocrinology Targets：Glucocorticoid Receptor Related Screening Libraries:Bioactive Compound Library Plus; Related Small Molecules:Deflazacort-D5;Glucocorticoid receptor agonist-2;AZD2906;Beclometasone dipropionate;ORIC-101;Clobetasone butyrate;Cortisone-d2;Clobetasone butyrate-d7;Cortisone-13C3;Glucocorticoid receptor agonist;Cortodoxone-d2;Hydrocortisone aceponate;Glucocorticoid receptor-IN-2;OP-3633;GW-870086;Nenocorilant;Hydrocortisone cypionate;Corticosterone-d8;21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione;Deflazacort-d5-1;Mapracorat;Hydrocortisone-d4;Hydrocortisone acetate Trending […]

For research use only. We do not sell to patients. RTICBM-189 CAS No. : 551909-15-0 Biological Activity：RTICBM-189 is a potent, brain-penetrant allosteric modulator of the cannabinoid type-1 (CB1) receptor with a pIC50 of 7.54 in Ca2+ mobilization assay. RTICBM-189 has pIC50s of 5.29 and 6.25 for hCB1 and mCB1, respectively. RTICBM-189 significantly and selectively attenuates […]