Tag: Modulator

For research use only. We do not sell to patients. 6-(γ,γ-Dimethylallylamino)purine CAS No. : 2365-40-4 Biological Activity：6-(γ,γ-Dimethylallylamino)purine is a plant growth substance. Research Area：Others Targets：Others Related Screening Libraries:Natural Product Library Plus;Bioactive Compound Library Plus;Natural Product Library;Traditional Chinese Medicine Active Compound Library;Microbial Metabolite Library;Food-Sourced Compound Library ;Human Metabolite Library; Related Small Molecules:Immune initiator-1;Obiltoxaximab;DIBAC-GGFG-NH2CH2-Dxd;Cyanine5.5 maleimide chloride;Cymarin;Z-Glycine;2-Deoxy-2-fluoro-D-glucose-13C,d7;Water-18O;Fmoc-N-Me-D-Ala-OH;3,5-Diiodo-L-tyrosine;N3-Pen-Dde;Zimeldine-d6;Ornidazole diol;Nylidrin […]

For research use only. We do not sell to patients. RA-2 CAS No. : 1867107-62-7 Biological Activity：RA-2 is a negative-gating modulator of KCa2/3 channels with an IC50 of 17 nM. RA-2 inhibits bradykinin-induced endothelium-derived hyperpolarization (EDH)-type relaxation in U46619-precontracted rings. RA-2 can help to define the physiologic and pathomechanistic roles of KCa2/3 in the vasculature, […]

For research use only. We do not sell to patients. Fmoc-leucine-d10 CAS No. : 1190594-22-9 Biological Activity：Fmoc-leucine-d10 is the deuterium labeled Fmoc-leucine. Fmoc-leucine is a selective PPARγ modulator. Fmoc-leucine activates PPARγ with a lower potency but a similar maximal efficacy than rosiglitazone. Fmoc-leucine improves insulin sensitivity in normal, diet-induced glucose-intolerant, and in diabetic db/db mice. […]

For research use only. We do not sell to patients. Raloxifene 6-glucuronide CAS No. : 174264-50-7 Biological Activity：Raloxifene 6-glucuronide is a primary metabolite of Raloxifene. Raloxifene 6-glucuronide is mediated mostly by UGT1A1 and UGT1A8. Raloxifene 6-glucuronide binds to estrogen receptor with an IC50 of 290 μM. Raloxifene is a selective and nonsteroidal estrogen receptor modulator. […]

For research use only. We do not sell to patients. MK-7622 CAS No. : 1227923-29-6 Biological Activity：MK-7622 (M1 receptor modulator) is a muscarinic M1 receptor positive allosteric modulator[2]. Research Area：Neurological Disease Targets：mAChR Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Neuronal Signaling Compound Library;Clinical Compound Library;Drug Repurposing Compound […]

For research use only. We do not sell to patients. N-Hexanoyl-L-homoserine lactone CAS No. : 147852-83-3 Biological Activity：N-Hexanoyl-L-homoserine lactone is a short-chained N-acyl homoserine lactone (AHL). Diatoms are frequently found in association with Proteobacteria, many members of which employ cell-to-cell communication via AHLs in aquatic habitats. Research Area：Infection Targets：Bacterial Related Small Molecules:Sandramycin;LLO (91-99);Gepotidacin;Oritavancin;Azlocillin sodium salt;Herbimycin […]

For research use only. We do not sell to patients. Toremifene CAS No. : 89778-26-7 Biological Activity：Toremifene (Z-Toremifene) is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis. Toremifene also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.07 µM and 2.6 µM, respectively[2]. Research Area：Cancer|Infection Targets：Estrogen Receptor/ERR […]

For research use only. We do not sell to patients. Bazedoxifene-d4 N-Oxide CAS No. : 1794810-68-6 Biological Activity：Bazedoxifene-d4 N-Oxide is the deuterium labeled Bazedoxifene. Bazedoxifene (TSE-424) is an oral, BBB-penetrant nonsteroidal selective estrogen receptor modulator (SERM), with IC50s of 23 nM and 99 nM for ERα and ERβ, respectively. Bazedoxifene can be used for the […]

For research use only. We do not sell to patients. CXCR7 modulator 2 CAS No. : 2227426-37-9 Biological Activity：CXCR7 modulator 2 is a modulator of C-X-C Chemokine Receptor Type 7 (CXCR7), with a Ki of 13 nM. Research Area：Cardiovascular Disease|Endocrinology Targets：CXCR Related Screening Libraries:Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Immunology/Inflammation Compound Library;Small Molecule Immuno-Oncology Compound […]

For research use only. We do not sell to patients. α-Helical CRF(9-41) TFA Biological Activity：α-Helical CRF(9-41) TFA is a competitive CRF2 receptor antagonist with KB of ~100 nM. α-Helical CRF(9-41) TFA is also a partial agonist of CRF1 receptor with an EC50 of 140 nM[2]. Research Area：Neurological Disease Targets：CRFR Related Screening Libraries:Bioactive Compound Library Plus;Peptide […]