Tag: Modulator

For research use only. We do not sell to patients. MRGPRX1 agonist 4 Biological Activity：MRGPRX1 agonist 4 (compound 1t) is a potent and orally active Mas-related G protein-coupled receptor X1 (MRGPRX1) positive allosteric modulator with an EC50 value of 0.1 μM. MRGPRX1 agonist 4 has good metabolic stability and oral bioavailability. MRGPRX1 agonist 4 can […]

For research use only. We do not sell to patients. Bradykinin (1-5) CAS No. : 23815-89-6 Biological Activity：Bradykinin (1-5) is a major stable metabolite of Bradykinin, formed by the proteolytic action of angiotensin-converting enzyme (ACE). Research Area：Cardiovascular Disease|Endocrinology Targets：Bradykinin Receptor Related Screening Libraries:Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Anti-Cardiovascular Disease Compound Library;Endocrinology Compound Library;Neurotransmitter Receptor […]

For research use only. We do not sell to patients. MNI137 CAS No. : 946619-21-2 Biological Activity：MNI137 is a potent and selective negative allosteric modulator for group II mGluRs. MNI137 has IC50s values of 8.3 and 12.6 nM for human and rat mGlu2 inhibition of glutamate-induced calcium mobilization. Research Area：Neurological Disease Targets：mGluR Related Small Molecules:LY3020371 […]

For research use only. We do not sell to patients. Dovitinib-RIBOTAC CAS No. : 2759351-68-1 Biological Activity：Dovitinib RIBOTAC is a targeted RNA degrader that cleaves pre-miR-21 with enhanced potency and selectivity. Research Area：Cancer Targets：PROTACs Related Small Molecules:PROTAC Sirt2 Degrader-1;DB0614;PROTAC VEGFR-2 degrader-2;dTAGV-1-NEG;CCT367766 formic;HDAC6 degrader-1;PROTAC Axl Degrader 2;PhosTAC7;MS98;JPS014;PROTAC PARP1 degrader;MD-224;FKBP12 PROTAC dTAG-7;SJ10542;MS8815;RIP2 Kinase Inhibitor 4;PROTAC EGFR degrader […]

For research use only. We do not sell to patients. ZXH-1-161 CAS No. : 2407654-51-5 Biological Activity：ZXH-1-161 is a potent cereblon (CRBN) modulator with an IC50 value of 39 nM in MM1.S wild type cells. ZXH-1-161 has selective degradation activity towards GSPT1. ZXH-1-161 can be used for researching multiple myeloma. Research Area：Cancer Targets：Ligands for E3 […]

For research use only. We do not sell to patients. Ospemifene-d4-1 CAS No. : 2734564-80-6 Biological Activity：Ospemifene-d4-1 (FC-1271a-d4-1) is the deuterium labeled Ospemifene. Ospemifene is a non-estrogen selective estrogen receptor modulator (SERM), with Kis of 380 and 410 nM for estrogen receptor α (ERα) and ERβ, respectively. Ospemifene can be used for the research of […]

For research use only. We do not sell to patients. N-3-oxo-dodecanoyl-L-homoserine lactone CAS No. : 168982-69-2 Biological Activity：N-3-oxo-dodecanoyl-L-Homoserine lactone (3-oxo-C12-HSL) is a bacterial quorum-sensing signaling molecule produced by P. aeruginosa and strains of the B. cepacia complex[2].Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density.N-3-oxo-dodecanoyl-L-Homoserine […]

For research use only. We do not sell to patients. Emraclidine CAS No. : 2170722-84-4 Biological Activity：Emraclidine (CVL-231) is a muscarinic M4 receptor positive allosteric modulator (WO2018002760, compound 11). Emraclidine can be used for the research of neurological diseases. Research Area：Neurological Disease Targets：mAChR Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library […]

For research use only. We do not sell to patients. YL-109 CAS No. : 36341-25-0 Biological Activity：YL-109 is an antitumor agent that can induce carboxyl terminus of Hsp70-interacting protein (CHIP) expression through aryl hydrocarbon receptor (AhR) signaling. YL-109 has ability to inhibit breast cancer cell growth and invasiveness. Research Area：Cancer Targets：Aryl Hydrocarbon Receptor Related Screening […]

For research use only. We do not sell to patients. Olacaftor CAS No. : 1897384-89-2 Biological Activity：Olacaftor (VX-440) is a cystic fibrosis transmembrane conductance regulator (CFTR) modulator extracted from patent US9782408. Research Area：Inflammation/Immunology Targets：CFTR|Autophagy Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus; Related Small Molecules:PG01;CFTR corrector 8;CP-628006;SRI-37240;Urocortin III (mouse) (free […]