Tag: Modulator

For research use only. We do not sell to patients. JTE-907 CAS No. : 282089-49-0 Biological Activity：JTE-907 is a highly selective, orally active CB2 receptor inverse agonist and exerts anti-inflammatory effects in vivo. Research Area：Inflammation/Immunology Targets：Cannabinoid Receptor Related Screening Libraries:Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Immunology/Inflammation Compound Library;Neuronal Signaling Compound Library; Related Small Molecules:Pregnenolone monosulfate […]

For research use only. We do not sell to patients. Lumacaftor CAS No. : 936727-05-8 Biological Activity：Lumacaftor (VX-809; VRT 826809) is a CFTR modulator that corrects the folding and trafficking of CFTR protein. Research Area：Inflammation/Immunology Targets：CFTR|Autophagy Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;Membrane Transporter/Ion […]

For research use only. We do not sell to patients. Fmoc-leucine CAS No. : 35661-60-0 Biological Activity：Fmoc-leucine is a selective PPARγ modulator. Fmoc-leucine activates PPARγ with a lower potency but a similar maximal efficacy than rosiglitazone. Fmoc-leucine improves insulin sensitivity in normal, diet-induced glucose-intolerant, and in diabetic db/db mice. Fmoc-leucine has a lower adipogenic activity. […]

For research use only. We do not sell to patients. NMDA receptor modulator 3 CAS No. : 2758256-02-7 Biological Activity：NMDA receptor modulator 3 (Compound 99) is a potent NMDA receptor modulator. NMDA receptor modulator 3 can be used for neurological disorder research. Research Area：Neurological Disease Targets：iGluR Related Small Molecules:CIQ;Quinolinic acid-d3;1-Aminocyclobutanecarboxylic acid;Glycine-1-13C,15N;ZL006;PYD-106;NMDA-IN-2;JAMI1001A;(S)-Willardiine;Fanapanel;(S)-AMPA;L-Glutamic acid-15N,d5;PDZ1 Domain inhibitor peptide […]

For research use only. We do not sell to patients. Piracetam-d8 CAS No. : 1329799-64-5 Biological Activity：Piracetam-d8 (UCB-6215-d8) is the deuterium labeled Piracetam. Piracetam (UCB-6215) is a cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA), used in treatment of a wide range of cognitive disorders[2]. Research Area：Neurological Disease Targets：iGluR Related Small Molecules:CIQ;Quinolinic acid-d3;1-Aminocyclobutanecarboxylic acid;Glycine-1-13C,15N;ZL006;PYD-106;NMDA-IN-2;JAMI1001A;(S)-Willardiine;Fanapanel;(S)-AMPA;L-Glutamic acid-15N,d5;PDZ1 […]

For research use only. We do not sell to patients. NS11394 CAS No. : 951650-22-9 Biological Activity：NS11394 is an orally active and unique subtype-selective GABAA positive allosteric receptor (PAM), with a Ki of ~0.5 nM. NS11394 shows a selectivity profile in the order of GABAA-5 > α3 > α2 > α1-containing receptors. NS11394 has anxiolytic […]

For research use only. We do not sell to patients. Asoprisnil CAS No. : 199396-76-4 Biological Activity：Asoprisnil (J867), a selective progesterone receptor modulator, exhibits mixed progesterone agonist and antagonist effects on various progesterone targeted tissues in animal and human. Research Area：Endocrinology Targets：Progesterone Receptor Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library […]

For research use only. We do not sell to patients. Gaboxadol hydrochloride CAS No. : 85118-33-8 Biological Activity：Gaboxadol hydrochloride (Lu 02-030 hydrochloride) is a potent agonist of the GABAA receptor and an antagonist of GABAC receptors (IC50=25 μM). Gaboxadol hydrochloride displays a partial agonist efficacy on subunit α1β2γ2 with an ED50 value of 143 µM, […]

For research use only. We do not sell to patients. Lats-IN-1 CAS No. : 1424635-83-5 Biological Activity：Lats-IN-1 is a potent and ATP-competitive inhibitor of Lats1 and Lats2 kinases. Lats-IN-1 promotes Yap-dependent proliferation in postmitotic mammalian tissues. Research Area：Others Targets：YAP Related Screening Libraries:Bioactive Compound Library Plus;Kinase Inhibitor Library;Stem Cell Signaling Compound Library;Wnt/Hedgehog/Notch Compound Library;Anti-Aging Compound Library;Transcription […]

For research use only. We do not sell to patients. AUT1 CAS No. : 1311136-84-1 Biological Activity：AUT1 is a recombinant human Kv3 channel modulator. AUT1 modulates Kv3.1b and Kv3.2a channels in human recombinant with pEC50 values of 5.33 and 5.31 μM, respectively. AUT1 can be used for the research of disorders associated with dysfunction of […]