Tag: Modulator

For research use only. We do not sell to patients. Betahistine-13C,d3 dihydrochloride Biological Activity：Betahistine-13C,d3 (dihydrochloride) is the 13C- and deuterium labeled Betahistine (dihydrochloride). Betahistine dihydrochloride is an orally active histamine H1 receptor agonist and a H3 receptor antagonist. Betahistine dihydrochloride is used for the study of rheumatoid arthritis (RA)[3]. Research Area：Endocrinology|Inflammation/Immunology|Neurological Disease Targets：Histamine Receptor Related […]

For research use only. We do not sell to patients. PZ-2891 CAS No. : 2170608-82-7 Biological Activity：PZ-2891 is an orally bioavailable, brain penetrant pantothenate kinase (PANK) modulator. PZ-2891 act as an orthosteric inhibitor at high concentrations and an allosteric activator at lower sub-saturating concentrations. PZ-2891 inhibits human pantothenate kinases PANK1β, PANK2, and PANK3 with IC50s […]

For research use only. We do not sell to patients. AZD5423 CAS No. : 1034148-04-3 Biological Activity：AZD5423 is an inhaled, potent, selective, and non-steroidal glucocorticoid receptor (GR) modulator (SGRM). AZD5423 effectively reduces allergen-induced responses in subjects with mild allergic asthma[2]. Research Area：Inflammation/Immunology|Endocrinology Targets：Glucocorticoid Receptor Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound […]

For research use only. We do not sell to patients. RLX-33 CAS No. : 2784577-71-3 Biological Activity：RLX-33 is a potent, selective and blood-brain barrier (BBB) penetrant relaxin family peptide 3 (RXFP3) antagonist, also blocks relaxin-3-induced ERK1/2 phosphorylation, with IC50 values of 2.36 μM for RXFP3, 7.82 and 13.86 μM for ERK1 and ERK2 phosphorylation, respectively. […]

For research use only. We do not sell to patients. Onfasprodil CAS No. : 1892581-29-1 Biological Activity：Onfasprodil is negative allosteric modulator of NR2B. Onfasprodil in combination with GABA receptor regulator has the potential for the research of Alzheimer’s disease (extracted from patent CN111481543A). Research Area：Neurological Disease Targets：iGluR Related Small Molecules:CIQ;Quinolinic acid-d3;1-Aminocyclobutanecarboxylic acid;Glycine-1-13C,15N;ZL006;PYD-106;NMDA-IN-2;JAMI1001A;(S)-Willardiine;Fanapanel;(S)-AMPA;L-Glutamic acid-15N,d5;PDZ1 Domain inhibitor […]

For research use only. We do not sell to patients. Cyclo(RADfK) CAS No. : 756500-23-9 Biological Activity：Cyclo(RADfK) is a selective α(v)β(3) integrin ligand that has been extensively used for research, therapy, and diagnosis of neoangiogenesis. Research Area：Others Targets：Integrin Related Screening Libraries:Bioactive Compound Library Plus;Macrocyclic Compound Library;Peptide Library;Cyclic Peptide Library; Related Small Molecules:GRGDSPK;Integrin Binding Peptide;Cyclo(Arg-Gly-Asp-D-Phe-Cys);Zaurategrast ethyl […]

For research use only. We do not sell to patients. JTP-117968 CAS No. : 2250132-99-9 Biological Activity：JTP-117968, a novel selective glucocorticoid receptor modulator (a non-steroidal SGRM, IC50 of 6.8 nM), exhibits improved transrepression/transactivation dissociation. Research Area：Metabolic Disease Targets：Glucocorticoid Receptor Related Small Molecules:Deflazacort-D5;Glucocorticoid receptor agonist-2;AZD2906;Beclometasone dipropionate;ORIC-101;Clobetasone butyrate;Cortisone-d2;Clobetasone butyrate-d7;Cortisone-13C3;Glucocorticoid receptor agonist;Cortodoxone-d2;Hydrocortisone aceponate;Glucocorticoid receptor-IN-2;OP-3633;GW-870086;Nenocorilant;Hydrocortisone cypionate;Corticosterone-d8;21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione;Deflazacort-d5-1;Mapracorat;Hydrocortisone-d4;Hydrocortisone acetate Trending products：Recombinant […]

For research use only. We do not sell to patients. Fmoc-leucine-13C6,15N CAS No. : 1163133-36-5 Biological Activity：Fmoc-leucine-13C6,15N is a 15N-labeled and 13C-labled Fmoc-leucine. Fmoc-leucine is a selective PPARγ modulator. Fmoc-leucine activates PPARγ with a lower potency but a similar maximal efficacy than rosiglitazone. Fmoc-leucine improves insulin sensitivity Research Area：Metabolic Disease Targets：PPAR Related Small Molecules:Falcarindiol;5-Aminosalicylic Acid-D3 […]

For research use only. We do not sell to patients. LG100754 CAS No. : 180713-37-5 Biological Activity：LG100754 (UVI 2112) is a RXR dimers modulater. LG100754 acts as a RXR:RXR homodimer antagonist, but functions as a agonist towards RXR:PPARα and RXR:PPARγ heterodimers. LG100754 is an insulin sensitizer that functions through RXR. Research Area：Metabolic Disease Targets：RAR/RXR Related […]

For research use only. We do not sell to patients. PROTAC IRAK3 degrade-1 CAS No. : 2712600-00-3 Biological Activity：PROTAC IRAK3 degrade-1 is a potent and selective degrader of IRAK3 (IC50 = 5 nM). Research Area：Others Targets：PROTACs Related Small Molecules:PROTAC Sirt2 Degrader-1;DB0614;PROTAC VEGFR-2 degrader-2;dTAGV-1-NEG;CCT367766 formic;HDAC6 degrader-1;PROTAC Axl Degrader 2;PhosTAC7;MS98;JPS014;PROTAC PARP1 degrader;MD-224;FKBP12 PROTAC dTAG-7;SJ10542;MS8815;RIP2 Kinase Inhibitor 4;PROTAC […]