Tag: Modulator

For research use only. We do not sell to patients. Aceclidine CAS No. : 827-61-2 Biological Activity：Aceclidine is a modulator of M3 muscarinic acetylcholine receptor. Aceclidine is a cycloplegic agent, a surfactant, a tonicity adjustor and optionally a viscosity enhancer and an antioxidant. Aceclidine has the potential for the research of disorders such as refractive […]

For research use only. We do not sell to patients. Efaproxiral CAS No. : 131179-95-8 Biological Activity：Efaproxiral is a haemoglobin (Hb) synthetic allosteric modifier, decreases Hb-oxygen (O2) binding affinity and enhances oxygenation of hypoxic tumours during radiation therapy . Research Area：Cancer Targets：Reactive Oxygen Species Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound […]

For research use only. We do not sell to patients. BPN-15606 besylate Biological Activity：BPN-15606 besylate is a highly potent, orally active γ-secretase modulator (GSM), attenuates the production of Aβ42 and Aβ40 by SHSY5Y neuroblastoma cells with IC50 values of 7 nM and 17nM, respectively. BPN-15606 besylate lowers Aβ42 and Aβ40 levels in the central nervous […]

For research use only. We do not sell to patients. Pantothenate kinase-IN-1 CAS No. : 1024168-48-6 Biological Activity：Pantothenate kinase-IN-1 (Compound 1) is a pantothenate kinase (PANK) modulator with an IC50 of 0.51 µM against PANK3. Pantothenate kinase-IN-1 has a reasonable ligand efficiency (LipE = 2.8). Research Area：Neurological Disease Targets：Others Related Small Molecules:Immune initiator-1;Obiltoxaximab;DIBAC-GGFG-NH2CH2-Dxd;Cyanine5.5 maleimide chloride;Cymarin;Z-Glycine;2-Deoxy-2-fluoro-D-glucose-13C,d7;Water-18O;Fmoc-N-Me-D-Ala-OH;3,5-Diiodo-L-tyrosine;N3-Pen-Dde;Zimeldine-d6;Ornidazole […]

For research use only. We do not sell to patients. Estetrol CAS No. : 15183-37-6 Biological Activity：Estetrol, a natural estrogen synthesized exclusively during pregnancy by the human fetal liver, is a selective nuclear estrogen receptor modulator. Estetrol exerts estrogenic actions on the endometrium or the central nervous system but presents antagonistic effects on the breast[2]. […]

For research use only. We do not sell to patients. SUN13837 CAS No. : 1080650-67-4 Biological Activity：SUN13837 is an orally active, potent and BBB-penetrated FGFR (fibroblast growth factor receptor) modulator. SUN13837 shows neuroprotective activity. SUN13837 can be used for neurodegenerative diseases research. Research Area：Neurological Disease Targets：FGFR Related Small Molecules:Ferulic acid-13C3;FGFR-IN-7;PP58;FGFR3-IN-1;ENMD-2076 Tartrate;R1530;FGFR3-IN-3;Tyrosine kinase-IN-1;Heparan Sulfate;Futibatinib;SU4984;Roblitinib;PD173074;PF 477736;FGFR4-IN-8;Lucitanib;Masitinib;Zoligratinib;FGFR4-IN-4;BLU9931;SM1-71;VSPPLTLGQLLS TFA;TG […]

For research use only. We do not sell to patients. Nesolicaftor CAS No. : 1953130-87-4 Biological Activity：Nesolicaftor (PTI-428) is a specific cystic fibrosis transmembrane conductance regulator (CFTR) amplifier. Research Area：Endocrinology Targets：CFTR|Autophagy Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Membrane Transporter/Ion Channel Compound Library;Clinical Compound Library;Autophagy Compound Library;Drug Repurposing Compound Library;Endocrinology […]

For research use only. We do not sell to patients. Palmitoylglycine CAS No. : 2441-41-0 Biological Activity：Palmitoylglycine (N-palmitoyl glycine), an endogenous lipid that acts as a modulator of calcium influx and nitric oxide (NO) production in sensory neurons. Research Area：Inflammation/Immunology|Neurological Disease Targets：Calcium Channel|NO Synthase Related Screening Libraries:Natural Product Library Plus;Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;Membrane […]

For research use only. We do not sell to patients. VU0422288 CAS No. : 1630936-95-6 Biological Activity：VU0422288 is a positive allosteric modulator of group III mGluRs with EC50 values of 108, 146, and 128 nM for mGluR4, mGluR7, and mGluR8, respectively in calcium mobilization assays. Research Area：Neurological Disease Targets：mGluR Related Small Molecules:LY3020371 hydrochloride;ZJ43;FPTQ;(S)-MCPG;mGluR2 modulator 1;VU6010572;Mavoglurant […]

For research use only. We do not sell to patients. Eltoprazine CAS No. : 98224-03-4 Biological Activity：Eltoprazine(DU28853) is a serenic or antiaggressive agent which as an agonist at the 5-HT1A and 5-HT1B receptors and as an antagonist at the 5-HT2C receptor. IC50 value: Target: 5-HT1A/1B agonist; 5-HT2C antagonist in vitro: The binding of [3H]eltoprazine to […]