Tag: Inhibitor|Inducer|MDM2 Inhibitor

For research use only. We do not sell to patients. Serdemetan CAS No. : 881202-45-5 Biological Activity：Serdemetan(JNJ-26854165) acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells, inhibits cellular proliferation followed by delayed apoptosis in the absence of functional p53. IC50 value: HDM2 ubiquitin ligase Target: in vitro: JNJ […]

For research use only. We do not sell to patients. Alrizomadlin CAS No. : 1818393-16-6 Biological Activity：Alrizomadlin (APG-115) is an orally active MDM2 protein inhibitor binding to MDM2 protein with IC50 and Ki values of 3.8 nM and 1 nM, respectively. Alrizomadlin blocks the interaction of MDM2 and p53 and induces cell-cycle arrest and apoptosis […]