Tag: Inhibitor|Inducer

For research use only. We do not sell to patients. Tofacitinib CAS No. : 477600-75-2 Biological Activity：Tofacitinib is an orally available JAK3/2/1 inhibitor with IC50s of 1, 20, and 112 nM, respectively. Research Area：Inflammation/Immunology|Cancer Targets：JAK|Apoptosis Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Apoptosis Compound Library;Epigenetics Compound Library;Immunology/Inflammation […]

For research use only. We do not sell to patients. MDM2/4-p53-IN-2 Biological Activity：MDM2/4-p53-IN-2 (2q) is a potent dual MDM2/ MDM4 inhibitor and p53 activator with the IC50 values of 70.7 nM for MDM2- p53 and 81.4 nM for MDM4-p53 complexes. MDM2/4-p53-IN-2 regulates the cell cycle, induces cell apoptosis and has anticancer activity. Research Area：Cancer Targets：MDM-2/p53|Apoptosis […]

For research use only. We do not sell to patients. 1-Alaninechlamydocin CAS No. : 141446-96-0 Biological Activity：1-Alaninechlamydocin, a cyclic tetrapeptide, is a potent HDAC inhibitor (IC50=6.4 nM). 1-Alaninechlamydocin induces G2/M cell cycle arrest and apoptosis in MIA PaCa-2 cells. Research Area：Cancer Targets：HDAC|Apoptosis Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;Xevinapant;Mangiferin;Cambinol;Antioxidant agent-5;Apoptosis inducer 9;Bafetinib;Cyclovirobuxine […]

For research use only. We do not sell to patients. Pexidartinib CAS No. : 1029044-16-3 Biological Activity：Pexidartinib (PLX-3397) is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit inhibitor, with IC50s of 20 and 10 nM, respectively. Pexidartinib (PLX-3397) exhibits 10- to 100-fold selectivity for c-Kit and […]

For research use only. We do not sell to patients. Taltobulin CAS No. : 228266-40-8 Biological Activity：Taltobulin (HTI-286), a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Taltobulin inhibits the polymerization of purified tubulin, disrupts microtubule organization in cells, and induces mitotic arrest, […]

For research use only. We do not sell to patients. Isoalantolactone CAS No. : 470-17-7 Biological Activity：Isoalantolactone is an apoptosis inducer, which also acts as an alkylating agent. Research Area：Cancer Targets：Autophagy|Bacterial|Endogenous Metabolite|Apoptosis Related Screening Libraries:Covalent Screening Library Plus;Natural Product Library Plus;Bioactive Compound Library Plus;Anti-Infection Compound Library;Apoptosis Compound Library;Metabolism/Protease Compound Library;Natural Product Library;Anti-Cancer Compound Library;Autophagy Compound […]

For research use only. We do not sell to patients. PROTAC EGFR degrader 7 Biological Activity：PROTAC EGFR degrader 7 (compound 13b) is a potent and selective CRBN-recruiting PROTAC EGFRL858R/T790M degrader, with a DC50 of 13.2 nM. PROTAC EGFR degrader 7 inhibits NCI–H1975 cells proliferation, with an IC50 of 46.82 nM. PROTAC EGFR degrader 7 significantly […]

For research use only. We do not sell to patients. Oxaliplatin CAS No. : 61825-94-3 Biological Activity：Oxaliplatin is a DNA synthesis inhibitor. Oxaliplatin causes DNA crosslinking damage, prevents DNA replication and transcription and induces apoptosis. Oxaliplatin can be used for cancer research[2][3]. Research Area：Cancer Targets：DNA/RNA Synthesis|Apoptosis Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library […]

For research use only. We do not sell to patients. Cucurbitacin E CAS No. : 18444-66-1 Biological Activity：Cucurbitacin E is a natural compound which from Cucurbitaceae plants. Cucurbitacin E significantly suppresses the activity of the cyclin B1/CDC2 complex. Research Area：Cancer Targets：Autophagy|CDK Related Screening Libraries:Natural Product Library Plus;Bioactive Compound Library Plus;Cell Cycle/DNA Damage Compound Library;Kinase Inhibitor […]

For research use only. We do not sell to patients. Docetaxel-d9 CAS No. : 940867-25-4 Biological Activity：Docetaxel-d9 (RP-56976-d9) is the deuterium labeled Docetaxel. Docetaxel (RP-56976) is a microtubule depolymerization inhibitor, with an IC50 of 0.2 μM. Docetaxel attenuates the effects of bcl-2 and bcl-xL gene expression. Docetaxel arrests the cell cycle at G2/M and leads to cell […]