Tag: Inhibitor|Inducer

For research use only. We do not sell to patients. GSK 3 Inhibitor IX CAS No. : 667463-62-9 Biological Activity：GSK 3 Inhibitor IX (6-Bromoindirubin-3′-oxime; BIO) is a potent, selective, reversible and ATP-competitive inhibitor of GSK-3α/β and CDK1-cyclinB complex with IC50s of 5 nM/320 nM/80 nM for (GSK-3α/β)/CDK1/CDK5, respectively. Research Area：Cancer Targets：CDK|GSK-3|Apoptosis Related Screening Libraries:Drug Repurposing […]

For research use only. We do not sell to patients. HDAC1/6-IN-1 CAS No. : 2630989-02-3 Biological Activity：HDAC1/6-IN-1 (compound D7) is a potent multitarget inhibitor of GLP, HDAC6 and HDAC1, with IC50 values of 1.3, 13, and 89 nM, respectively. HDAC1/6-IN-1 can inhibit the methylation and deacetylation of H3K9 on protein level. HDAC1/6-IN-1 induces cancer cell […]

For research use only. We do not sell to patients. Berbamine CAS No. : 478-61-5 Biological Activity：Berbamine is a natural compound extracted from traditional Chinese medicine Phellodendron amurense Rupr. with anti-tumor, immunomodulatory and cardiovascular effects. Berbamine is a calcium channel blocker. Research Area：Cancer Targets：Autophagy|NF-κB Related Screening Libraries:Natural Product Library Plus;Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved […]

For research use only. We do not sell to patients. Palomid 529 CAS No. : 914913-88-5 Biological Activity：Palomid 529 is a potent inhibitor of mTORC1 and mTORC2 complexes. Research Area：Cancer Targets：mTOR|Apoptosis Related Screening Libraries:Clinical Compound Library Plus;Bioactive Compound Library Plus;Apoptosis Compound Library;Kinase Inhibitor Library;PI3K/Akt/mTOR Compound Library;Stem Cell Signaling Compound Library;Anti-Cancer Compound Library;Clinical Compound Library;Autophagy Compound […]

For research use only. We do not sell to patients. PI3Kα-IN-8 Biological Activity：PI3Kα-IN-8 (Compound 9g) is a selective PI3Kα inhibitor with an IC50 of 0.012 μM. PI3Kα-IN-8 increases intracellular reactive oxygen species level, decreases mitochondrial membrane potential and induces apoptosis. Research Area：Cancer Targets：Reactive Oxygen Species|Apoptosis|PI3K Related Small Molecules:D-α-Hydroxyglutaric acid disodium;Physalin A;Bomedemstat ditosylate;Chitoheptaose heptahydrochloride;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;Umbralisib hydrochloride;N-Acetyl-D-cysteine;BJE6-106;Dinaciclib;Ecteinascidin […]

For research use only. We do not sell to patients. Retro-2 CAS No. : 1201652-50-7 Biological Activity：Retro-2 is a selective inhibitor of retrograde protein trafficking at the endosome-trans-Golgi network interface. Retro-2 is an ebolavirus (EBOV) infection inhibitor with an EC50 of 12.2 µM in HeLa cells. Retro-2 induces cell autophagy[2][3]. Research Area：Cancer|Infection Targets：Parasite|Autophagy|Filovirus Related Screening […]

For research use only. We do not sell to patients. Bergapten CAS No. : 484-20-8 Biological Activity：Bergapten is a natural anti-inflammatory and anti-tumor agent. Bergapten is inhibitory towards mouse and human CYP isoforms. Research Area：Cancer Targets：Autophagy|Cytochrome P450 Related Screening Libraries:Natural Product Library Plus;Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Metabolism/Protease Compound Library;Natural […]

For research use only. We do not sell to patients. ZMF-10 CAS No. : 2415295-37-1 Biological Activity：ZMF-10 is a highly potent PAK1 inhibitor, with IC50s of 174 nM, 1.038 μM and 1.372 μM for PAK1, PAK2 and PAK3, respectively. ZMF-10 can inhibit PAK1 activity to affect PAK1-regulated apoptosis, ER-Stress and migration in MDA-MB-231 cells. ZMF-10 […]

For research use only. We do not sell to patients. Thapsigargin CAS No. : 67526-95-8 Biological Activity：Thapsigargin, an endoplasmic reticulum (ER) stress inducer, is an inhibitor of microsomal Ca2+-ATPase. Thapsigargin efficiently inhibits coronavirus (HCoV-229E, MERS-CoV, SARS-CoV-2) replication in different cell types[2][3][4][5]. Research Area：Cancer|Infection Targets：Calcium Channel|Apoptosis|SARS-CoV Related Screening Libraries:Natural Product Library Plus;Bioactive Compound Library Plus; Related […]

For research use only. We do not sell to patients. Pyoluteorin CAS No. : 25683-07-2 Biological Activity：Pyoluteorin is an antibiotic that inhibits Oomycete fungi, including the plant pathogen Pythium ultimum, and suppresses plant diseases caused by this fungus. Pyoluteorin induces human triple-negative breast cancer MDA-MB-231 cells apoptosis in vitro. Pyoluteorin can be used for the […]