Tag: Inhibitor|Inducer

For research use only. We do not sell to patients. TCS JNK 5a CAS No. : 312917-14-9 Biological Activity：TCS JNK 5a is a potent JNK3 inhibitor with a pIC50 of 6.7. TCS JNK 5a also inhibits JNK2 with a pIC50 of 6.5. Research Area：Cancer Targets：Apoptosis|JNK Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Immunology/Inflammation Compound Library;Kinase […]

For research use only. We do not sell to patients. SD-36 CAS No. : 2429877-44-9 Biological Activity：SD-36 is a potent and efficacious STAT3 PROTAC degrader (Kd=~50 nM), and demonstrates high selectivity over other STAT members. SD-36 also effectively degrades mutated STAT3 proteins in cells and suppresses the transcriptional activity of STAT3 (IC50=10 nM). SD-36 exerts […]

For research use only. We do not sell to patients. Topoisomerase II inhibitor 10 CAS No. : 2488208-96-2 Biological Activity：Topoisomerase II inhibitor 10 (compound 32a) is a potent topoisomerase II inhibitor with an IC50 value of 7.45 μM. Topoisomerase II inhibitor 10 causes cell cycle arrest at G2-M phase and induces apoptosis of HepG-2 cells. […]

For research use only. We do not sell to patients. Rabeprazole-d4 CAS No. : 934295-48-4 Biological Activity：Rabeprazole D4 (LY307640 D4) is a deuterium labeled Rabeprazole. Rabeprazole is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H+/K+-ATPase. Rabeprazole induces apoptosis. Rabeprazole acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 […]

For research use only. We do not sell to patients. ACBI1 CAS No. : 2375564-55-7 Biological Activity：ACBI1 is a potent and cooperative SMARCA2, SMARCA4 and PBRM1 degrader with DC50s of 6, 11 and 32 nM, respectively. ACBI1 is a PROTAC degrader. ACBI1 shows anti-proliferative activity. ACBI1 induces apoptosis. Research Area：Cancer Targets：Epigenetic Reader Domain|PROTACs|Apoptosis Related Screening […]

For research use only. We do not sell to patients. Oroxylin A CAS No. : 480-11-5 Biological Activity：Oroxylin A is a natural active flavonoid with strong anticancer effects. IC50 value: Target: In vitro: Oroxylin A suppressed the MDM2-mediated degradation of p53 via downregulating MDM2 transcription in wt-p53 cancer cells [1]. Oroxylin A remarkably reduced the […]

For research use only. We do not sell to patients. SIAIS164018 CAS No. : 2353492-68-7 Biological Activity：SIAIS164018 is a PROTAC-based ALK and EGFR degrader, which is designed from Brigatinib (HY-12857), with IC50 value of 2.5 nM and 6.6 nM for ALK and ALK G1202R, respectively. SIAIS164018 strongly inhibits cancer cells migration and invasion, causes G1 […]

For research use only. We do not sell to patients. Tezacitabine CAS No. : 130306-02-4 Biological Activity：Tezacitabine is a cytostatic and cytotoxic antimetabolite and a nucleoside analogue. Tezacitabine irreversibly inhibits the ribonucleotide reductase and interferes with DNA replication and repair. Tezacitabine effectively induces cells apoptotic. Tezacitabine has the potential for leukemias and solid tumors (carcinomas) […]

For research use only. We do not sell to patients. Dihydrokaempferol CAS No. : 480-20-6 Biological Activity：Dihydrokaempferol is isolated from Bauhinia championii (Benth). Dihydrokaempferol induces apoptosis and inhibits Bcl-2 and Bcl-xL expression. Dihydrokaempferol is a good candidate for new antiarthritic drugs. Research Area：Inflammation/Immunology Targets：Bcl-2 Family|Apoptosis Related Screening Libraries:Natural Product Library Plus;Bioactive Compound Library Plus;Apoptosis Compound […]

For research use only. We do not sell to patients. Glucosamine hydrochloride CAS No. : 66-84-2 Biological Activity：Glucosamine hydrochloride (D-Glucosamine hydrochloride) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine hydrochloride also is a natural constituent of glycosaminoglycans in the […]