Tag: Inhibitor|Inducer

For research use only. We do not sell to patients. Lorlatinib CAS No. : 1454846-35-5 Biological Activity：Lorlatinib (PF-06463922) is a selective, orally active, brain-penetrant and ATP-competitive ROS1/ALK inhibitor. Lorlatinib has Kis of

For research use only. We do not sell to patients. HDAC-IN-46 CAS No. : 2562386-85-8 Biological Activity：HDAC-IN-46 (compound 12c) is a potent HDAC inhibitor with an IC50 value of 0.21 μM and 0.021 μM for HDAC1 and HDAC6, respectively. HDAC-IN-46 upregulates p-p38, and downregulates Bcl-xL and cyclin D1 in MDA-MB-231 cells. HDAC-IN-46 induces significant G2 […]

For research use only. We do not sell to patients. Xantocillin CAS No. : 580-74-5 Biological Activity：Xantocillin (Xanthocillin X) is a marine agent extracted from Penicillium commune, induces autophagy through inhibition of the MEK/ERK pathway. Research Area：Cancer Targets：MEK|Autophagy|ERK Related Small Molecules:Avutometinib;Cobimetinib racemate;Corynoxeine;EBI-1051;Temuterkib;CHMFL-EGFR-202;CKLF1-C27;LM22B-10;ERK5-IN-4;BI-847325;Pachymic acid;MAP855;6-OAU;VX-11e;Pluripotin;2,5-Dihydroxyacetophenone;Astragaloside IV;RGB-286638;ERK1/2 inhibitor 1;Binimetinib;Longdaysin;PD0325901-O-C2-dioxolane;[Tyr8] Bradykinin;Gypenoside L Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  […]

For research use only. We do not sell to patients. Rabeprazole sodium CAS No. : 117976-90-6 Biological Activity：Rabeprazole sodium (LY307640 sodium) is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H+/K+-ATPase. Rabeprazole sodium induces apoptosis. Rabeprazole sodium acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole sodium […]

For research use only. We do not sell to patients. Mezigdomide CAS No. : 2259648-80-9 Biological Activity：Mezigdomide (CC-92480), a cereblon E3 ubiquitin ligase modulating drug (CELMoD), acts as a molecular glue. Mezigdomide shows high affinity to cereblon, resulting in potent antimyeloma activity. Research Area：Cancer Targets：Apoptosis|E1/E2/E3 Enzyme|Molecular Glues Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound […]

For research use only. We do not sell to patients. Copanlisib CAS No. : 1032568-63-0 Biological Activity：Copanlisib (BAY 80-6946) is a potent, selective and ATP-competitive pan-class I PI3K inhibitor, with IC50s of 0.5 nM, 0.7 nM, 3.7 nM and 6.4 nM for PI3Kα, PI3Kδ, PI3Kβ and PI3Kγ, respectively. Copanlisib has more than 2,000-fold selectivity against […]

For research use only. We do not sell to patients. Inavolisib CAS No. : 2060571-02-8 Biological Activity：GDC-0077 (RG6114) is a potent, orally available, and selective PI3Kα inhibitor (IC50=0.038 nM). GDC-0077 (RG6114) exerts its activity by binding to the ATP binding site of PI3K, thereby inhibiting the phosphorylation of PIP2 to PIP3. GDC-0077 (RG6114) is more […]

For research use only. We do not sell to patients. BGT226 CAS No. : 915020-55-2 Biological Activity：BGT226 (NVP-BGT226) is a PI3K (with IC50s of 4 nM, 63 nM and 38 nM for PI3Kα, PI3Kβ and PI3Kγ)/mTOR dual inhibitor which displays potent growth-inhibitory activity against human head and neck cancer cells[2]. Research Area：Cancer Targets：Autophagy|mTOR|PI3K Related Small […]

For research use only. We do not sell to patients. Tubulin polymerization-IN-6 Biological Activity：Tubulin polymerization-IN-6 (compound 5f) is a potent tubulin polymerization inhibitor, with an IC50 of 1.09 μM. Tubulin polymerization-IN-6 inhibits cell migration and tube formation and contributes to the anti-angiogenesis. Tubulin polymerization-IN-6 can greatly inhibit tumor growth on HT29 xenograft Balb/c nude mice. […]

For research use only. We do not sell to patients. Zardaverine CAS No. : 101975-10-4 Biological Activity：Zardaverine is an orally active and selective PDE3/4 inhibitor (IC50)=0.58 uM/0.17 uM) with potent bronchodilator activity. Zardaverine also selectively inhibits the proliferation of HCC cells and induces apoptosis and cycle arrest (G0/G1 phase). Zardaverine has good antitumor potential and […]