Tag: Inhibitor|Inducer

For research use only. We do not sell to patients. Nimustine hydrochloride CAS No. : 55661-38-6 Biological Activity：Nimustine hydrochloride (ACNU) is a DNA cross-linking and DNA alkylating agent, which induces DNA replication blocking lesions and DNA double-strand breaks and inhibits DNA synthesis, commonly used in chemotherapy for glioblastomas[2][3]. Research Area：Cancer Targets：DNA Alkylator/Crosslinker|DNA/RNA Synthesis|Apoptosis Related Screening […]

For research use only. We do not sell to patients. Vincristine sulfate CAS No. : 2068-78-2 Biological Activity：Vincristine sulfate is an antitumor vinca alkaloid which inhibits microtubule formation in mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage. It binds to microtubule with a Ki of 85 nM. Research Area：Cancer Targets：Microtubule/Tubulin|Apoptosis […]

For research use only. We do not sell to patients. DC-CPin711 CAS No. : 2447559-21-7 Biological Activity：DC-CPin711 is a potent and selective inhibitor of CREB-binding protein (CBP) bromodomain with an IC50 of 0.0626 μM. DC-CPin711 arrests cell cycle at G1 phase and induces apoptosis. Research Area：Cancer Targets：Epigenetic Reader Domain|Apoptosis Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;RVX-297;Lobetyolin;BRD4 […]

For research use only. We do not sell to patients. Ganoderic acid DM CAS No. : 173075-45-1 Biological Activity：Ganoderic acid DM, a natural triterpenoid isolated from Ganoderma lucidum, induces DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells. Ganoderic acid DM as a specific inhibitor of osteoclastogenesis[2]. Research Area：Cancer|Metabolic Disease|Inflammation/Immunology Targets：Apoptosis|PI3K […]

For research use only. We do not sell to patients. AKT inhibitor VIII CAS No. : 612847-09-3 Biological Activity：AKT inhibitor VIII (AKTi-1/2) is a cell-permeable quinoxaline compound that has been shown to potently, selectively, allosterically, and reversibly inhibit Akt1, Akt2, and Akt3 activity with IC50s of 58 nM, 210 nM, and 2119 nM, respectively. Research […]

For research use only. We do not sell to patients. Rosuvastatin CAS No. : 287714-41-4 Biological Activity：Rosuvastatin (ZD 4522) is a competitive HMG-CoA reductase inhibitor with an IC50 of 11 nM. Rosuvastatin potently blocks hERG current with an IC50 of 195 nM, delayed cardiac repolarization, and thereby prolonged action potential durations (APDs) and corrected QT […]

For research use only. We do not sell to patients. GEM144 CAS No. : 2487526-28-1 Biological Activity：GEM144 is a potent and orally active DNA polymerase α (POLA1) and HDAC 11 dual inhibitor. GEM144 induces acetylation of p53, activation of p21, G1/S cell cycle arrest, and apoptosis. GEM144 has significant antitumor activity in human orthotopic malignant […]

For research use only. We do not sell to patients. α-Lipoic Acid-d5 CAS No. : 1189471-66-6 Biological Activity：α-Lipoic Acid-d5 (Thioctic acid-d5) is the deuterium labeled α-Lipoic Acid. α-Lipoic Acid is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation[2][3]. α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated […]

For research use only. We do not sell to patients. PCI-34051 CAS No. : 950762-95-5 Biological Activity：PCI-34051 is a potent and selective HDAC8 inhibitor with IC50 of 10 nM, with >200-fold selectivity over the other HDAC isoforms. Research Area：Cancer Targets：HDAC|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Cell Cycle/DNA Damage Compound Library;Epigenetics Compound Library;Histone Modification […]

For research use only. We do not sell to patients. Cystamine (dihydrochloride） CAS No. : 56-17-7 Biological Activity：Cystamine (dihydrochloride) is the disulfide form of the free thiol, cysteamine. Cystamine is an orally active transglutaminase (Tgase) inhibitor. Cystamine also has inhibition activity for caspase-3 with an IC50 value of 23.6 μM. Cystamine can be used for […]