Tag: Inhibitor|Inducer

For research use only. We do not sell to patients. Vandetanib-d4 CAS No. : 1215100-18-7 Biological Activity：Vandetanib-d4 (ZD6474-d4) is the deuterium labeled Vandetanib. Vandetanib (ZD6474) is a potent, orally active inhibitor of VEGFR2/KDR tyrosine kinase activity (IC50=40 nM). Vandetanib also has activity versus the tyrosine kinase activity of VEGFR3/FLT4 (IC50=110 nM) and EGFR/HER1 (IC50=500 nM)[2]. […]

For research use only. We do not sell to patients. Selumetinib-d4 CAS No. : 2364350-70-7 Biological Activity：Selumetinib-d4 (AZD6244-d4) is the deuterium labeled Selumetinib. Selumetinib (AZD6244) is selective, non-ATP-competitive oral MEK1/2 inhibitor, with an IC50 of 14 nM for MEK1. Selumetinib (AZD6244) inhibits ERK1/2 phosphorylation. Research Area：Cancer Targets：MEK|Apoptosis Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Avutometinib;Lobetyolin;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II […]

For research use only. We do not sell to patients. Afatinib-d6 dimaleate Biological Activity：Afatinib-d6 dimaleate (BIBW 2992MA2-d6) is the deuterium labeled Afatinib dimaleate. Afatinib dimaleate is an irreversible EGFR family inhibitor with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively[2]. Research Area：Cancer Targets：EGFR|Autophagy Related Small […]

For research use only. We do not sell to patients. K-7174 dihydrochloride CAS No. : 191089-60-8 Biological Activity：K-7174 dihydrochloride is an orally active proteasome and GATA inhibitor. K-7174 dihydrochloride is a cell adhesion inhibitor. K-7174 dihydrochloride induces cell apoptosis. K-7174 dihydrochloride shows antitumor activities, it can be used for the research of cancer[2][3]. Research Area：Cancer|Inflammation/Immunology […]

For research use only. We do not sell to patients. (R)-(-)-Gossypol acetic acid CAS No. : 866541-93-7 Biological Activity：(R)-(-)-Gossypol acetic acid (AT-101 (acetic acid)) is the levorotatory isomer of a natural product Gossypol. AT-101 is determined to bind to Bcl-2, Mcl-1 and Bcl-xL proteins with Kis of 260±30 nM, 170±10 nM, and 480±40 nM, respectively. […]

For research use only. We do not sell to patients. Momelotinib-d8 CAS No. : 1619927-68-2 Biological Activity：Momelotinib-d8 (CYT387-d8) is the deuterium labeled Momelotinib (HY-10961). Momelotinib (CYT387) is an orally acitve and ATP-competitive inhibitor of JAK1/JAK2 with IC50a of 11 nM and 18 nM,respectively, shows much less activity against JAK3[2]. Research Area：Cancer Targets：JAK|Autophagy|Apoptosis Related Small Molecules:Physalin […]

For research use only. We do not sell to patients. XL388 CAS No. : 1251156-08-7 Biological Activity：XL388 is a highly potent and ATP-competitive mTOR inhibitor with an IC50 of 9.9 nM. XL388 simultaneously inhibits both mTORC1 and mTORC2. Research Area：Cancer Targets：Autophagy|mTOR Related Screening Libraries:Bioactive Compound Library Plus;Kinase Inhibitor Library;PI3K/Akt/mTOR Compound Library;Stem Cell Signaling Compound Library;Anti-Cancer […]

For research use only. We do not sell to patients. NSC 107512 CAS No. : 22242-89-3 Biological Activity：NSC 107512 is a potent inhibitor of cyclin-dependent kinase 9 (CDK9). NSC 107512 is a class of sangivamycin-like molecules (SLM). NSC 107512 inhibits growth and induces apoptosis of multiple myeloma tumors. Research Area：Cancer Targets：CDK|Apoptosis Related Screening Libraries:Bioactive Compound […]

For research use only. We do not sell to patients. Tiplaxtinin CAS No. : 393105-53-8 Biological Activity：Tiplaxtinin is a selective and orally efficacious inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC50 of 2.7 μM. Research Area：Metabolic Disease|Cancer Targets：PAI-1|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Metabolism/Protease Compound Library;Anti-Cancer Compound Library;Orally Active Compound Library;Angiogenesis-Related Compound Library;Coagulation […]

For research use only. We do not sell to patients. ZDLD13 CAS No. : 2762278-95-3 Biological Activity：ZDLD13, a β-carboline, is an orally active and selective CDK4/CycD3 inhibitor with an IC50 value of 0.38 μM. ZDLD13 exhibits potent anti-HCT116 activity including inhibition of colony formation, inhibition of invasion and migration, inducing of apoptosis, and arresting of […]