Tag: Inhibitor|Inducer

For research use only. We do not sell to patients. Oprozomib CAS No. : 935888-69-0 Biological Activity：Oprozomib (PR-047) is an orally bioavailable and selective peptide epoxyketone proteasome inhibitor with IC50s of 36 and 82 nM for proteasome (β5) and immunoproteasome (LMP7), respectively. Oprozomib (ONX 0912) induces apoptosis in MM cells. Research Area：Cancer Targets：Autophagy|Proteasome|Apoptosis Related Screening […]

For research use only. We do not sell to patients. STAT3-IN-13 CAS No. : 2248552-86-3 Biological Activity：STAT3-IN-13 (compound 6f) is a potent STAT3 inhibitor. STAT3-IN-13 has anti-proliferative effects and binds to the STAT3 SH2 domain with a KD of 0.46 μM. STAT3-IN-13 inhibits the phosphorylation of STAT3 Y705 and downstream target gene expression. STAT3-IN-13 induces […]

For research use only. We do not sell to patients. Docetaxel CAS No. : 114977-28-5 Biological Activity：Docetaxel (RP-56976) is a microtubule depolymerization inhibitor, with an IC50 of 0.2 μM. Docetaxel attenuates the effects of bcl-2 and bcl-xL gene expression. Docetaxel arrests the cell cycle at G2/M and leads to cell apoptosis. Docetaxel has anti-cancer activity[3]. Research Area：Cancer […]

For research use only. We do not sell to patients. Capmatinib CAS No. : 1029712-80-8 Biological Activity：Capmatinib (INC280; INCB28060) is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor (IC50=0.13 nM). Capmatinib can inhibit phosphorylation of c-MET as well as c-MET pathway downstream effectors such as ERK1/2, AKT, FAK, GAB1, and STAT3/5. Capmatinib […]

For research use only. We do not sell to patients. K-252c CAS No. : 85753-43-1 Biological Activity：K-252c, a staurosporine analog isolated from Nocardiopsis sp., is a cell-permeable PKC inhibitor, with an IC50 of 2.45 µM. K-252c induces apoptosis in human chronic myelogenous leukemia cancer cells. K-252c also inhibits β-lactamase, chymotrypsin, and malate dehydrogenase[2][3]. Research Area：Cancer|Infection […]

For research use only. We do not sell to patients. LDN-57444 CAS No. : 668467-91-2 Biological Activity：LDN-57444 is a reversible, competitive and site-directed inhibitor of ubiquitin C-terminal hydrolase L1 (UCH-L1), with an IC50 of 0.88 μM and a Ki of 0.40 μM; LDN-57444 also suppresses UCH-L3 activity, with an IC50 of 25 μM. Research Area：Neurological […]

For research use only. We do not sell to patients. Benzbromarone-d5 Biological Activity：Benzbromarone-d5 is deuterium labeled Benzbromarone. Research Area：Metabolic Disease Targets：Xanthine Oxidase|Apoptosis Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;Xevinapant;Mangiferin;Cambinol;Antioxidant agent-5;Apoptosis inducer 9;Bafetinib;Cyclovirobuxine D;STAT3-IN-10;Rigosertib sodium Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  […]

For research use only. We do not sell to patients. (R)-(-)-Gossypol CAS No. : 90141-22-3 Biological Activity：(R)-(-)-Gossypol (AT-101) is the levorotatory isomer of a natural product Gossypol. AT-101 is determined to bind to Bcl-2, Mcl-1 and Bcl-xL proteins with Kis of 260±30 nM, 170±10 nM, and 480±40 nM, respectively. Research Area：Cancer Targets：Autophagy|Bcl-2 Family Related Small […]

For research use only. We do not sell to patients. Veliparib CAS No. : 912444-00-9 Biological Activity：Veliparib (ABT-888) is a potent PARP inhibitor, inhibiting PARP1 and PARP2 with Kis of 5.2 and 2.9 nM, respectively. Research Area：Cancer Targets：PARP|Autophagy Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Cell Cycle/DNA Damage Compound Library;Epigenetics […]

For research use only. We do not sell to patients. Levobupivacaine hydrochloride CAS No. : 27262-48-2 Biological Activity：Levobupivacaine hydrochloride ((S)-(-)-Bupivacaine monohydrochloride) is a long-acting amide local anaesthetic. Levobupivacaine hydrochloride exerts anaesthetic and analgesic effects through reversible blockade of neuronal sodium channel. Levobupivacaine hydrochloride can inhibit impulse transmission and conduction in cardiovascular and other tissues, possessing […]