Tag: Inhibitor|Inducer

For research use only. We do not sell to patients. PTD-p65-P1 Peptide Biological Activity：PTD-p65-P1 Peptide is a potent, selective nuclear transcription factor NF-κB inhibitor and derives from the p65 subunit of NF-κB amino acid residues 271-282, which selectively inhibits NF-κB activation induced by various inflammatory stimulation, down-regulate NF-κB-mediated gene expression and up-regulate apoptosis[2]. Research Area：Cancer|Inflammation/Immunology […]

For research use only. We do not sell to patients. Damnacanthal-d3 CAS No. : 2733158-65-9 Biological Activity：Damnacanthal-d3 is the deuterium labeled Damnacanthal. Damnacanthal is an anthraquinone isolated from the root of Morinda citrifolia. Damnacanthal is a highly potent, selective inhibitor of p56lck tyrosine kinase activity. Natural Damnacanthal inhibits p56 lck autophosphorylation and phosphorylation of exogenous […]

For research use only. We do not sell to patients. SID 3712249 CAS No. : 522606-67-3 Biological Activity：SID 3712249 (MiR-544 Inhibitor 1) is a miR-544 biogenesis inhibitor. SID 3712249 binds directly to the precursor miRNA. SID 3712249 blocks production of the mature microRNA and decreases miR-544, HIF-1α, and ATM transcripts. SID 3712249 can be used […]

For research use only. We do not sell to patients. NSC 33994 CAS No. : 82058-16-0 Biological Activity：NSC 33994 (G6) is a selective JAK2 inhibitor, with an IC50 of 60 nM. Research Area：Cancer Targets：JAK|Autophagy Related Small Molecules:AZ-3;JAK3/BTK-IN-1;AT9283;Benzene hexabromide;(E/Z)-Zotiraciclib;JAK-IN-10;Baricitinib-d3;JAK3-IN-6;Coumermycin A1;Deucravacitinib;Momelotinib-3,3,5,5-d4;SJ10542;Delgocitinib;Upadacitinib;α7 nAchR-JAK2-STAT3 agonist 1;Filgotinib-d4;AZD-1480;JAK-IN-20;JAK3 covalent inhibitor-1;JAK3-IN-12;(R)-Reticuline-d3;JAK-IN-23;TCJL37;JAK-IN-5;NSC 42834 Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  […]

For research use only. We do not sell to patients. Gefitinib CAS No. : 184475-35-2 Biological Activity：Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. […]

For research use only. We do not sell to patients. PARP1-IN-10 CAS No. : 2494001-21-5 Biological Activity：PARP1-IN-10 (compound 12c) is a no-cytotoxicity and potent PARP1 inhibitor with an IC50 value of 50.62 nM in vitro. PARP1-IN-10 causes cell cycle arrest at G2/M phase and apoptosis, and enhances the cytotoxicity of temozolomide (TMZ) . Research Area：Cancer […]

For research use only. We do not sell to patients. Tigecycline hydrate CAS No. : 1229002-07-6 Biological Activity：Tigecycline (GAR-936) hydrate is a broad-spectrum glycylcycline antibiotic. The mean inhibitory concentration (MIC) of Tigecycline hydrate for E. coli (MG1655 strain) is approximately 125 ng/mL. MIC50 and MIC90 are 1 and 2 mg/L for Acinetobacter baumannii (A. baumannii), […]

For research use only. We do not sell to patients. G4/HDAC-IN-1 Biological Activity：G4/HDAC-IN-1 (compound a6) is a G4/HDAC dual-targeting compound. G4/HDAC-IN-1 inhibits intracellular HDAC activity with an IC50 value of 1.1 μM, and induces G4 formation. G4/HDAC-IN-1 inhibits TNBC proliferation and tumor growth in TNBC xenograft model. G4/HDAC-IN-1 can be used for the research of […]

For research use only. We do not sell to patients. AS-99 free base CAS No. : 2323623-93-2 Biological Activity：AS-99 is a first-in-class, potent and selective ASH1L histone methyltransferase inhibitor (IC50= 0.79 µM, Kd= 0.89 µM) with anti-leukemic activity. AS-99 blocks cell proliferation, induces apoptosis and differentiation, downregulates MLL fusion target genes, and reduces the leukemia burden in vivo. Research […]

For research use only. We do not sell to patients. SKI V CAS No. : 24418-86-8 Biological Activity：SKI V is a noncompetitive and potent non-lipid sphingosine kinase (SPHK; SK) inhibitor with an IC50 of 2 μM for GST-hSK. SKI V potently inhibits PI3K with an IC50 of 6 μM for hPI3k. SKI V decreases formation […]