Tag: Inhibitor|Inducer

For research use only. We do not sell to patients. Amiloride CAS No. : 2609-46-3 Biological Activity：Amiloride (MK-870) is an inhibitor of both epithelial sodium channel (ENaC) and urokinase-type plasminogen activator receptor (uTPA[2]). Amiloride is a blocker of polycystin-2 (PC2; TRPP2[3]) channel. Research Area：Metabolic Disease|Cardiovascular Disease Targets：TRP Channel|Sodium Channel|Apoptosis Related Small Molecules:Physalin A;Bomedemstat ditosylate;V116517;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;GSK2332255B;Pregnenolone […]

For research use only. We do not sell to patients. Enniatin A1 CAS No. : 4530-21-6 Biological Activity：Enniatin A1 isolated from Fusarium mycotoxins is a cyclic hexadepsipeptide consisting of alternating D-α-hydroxyisovaleric acids and N-methyl-L-amino acids. Enniatin A1 possesses anticarcinogenic properties by induction of apoptosis and disruption of ERK signalling pathway. Enniatin A1 inhibits ACAT with […]

For research use only. We do not sell to patients. Polyphyllin G CAS No. : 76296-75-8 Biological Activity：Polyphyllin G is isolated from the rhizomes of Paris yunnanensis, with antimicrobial and anticancer activity. Polyphyllin G prevents the growth of both Gram-positive and Gram-negative bacteria with minimum inhibitory concentrations (MICs). Polyphyllin G induces apoptosis dependent on the […]

For research use only. We do not sell to patients. Omipalisib CAS No. : 1086062-66-9 Biological Activity：Omipalisib (GSK2126458) is an orally active and highly selective inhibitor of PI3K with Kis of 0.019 nM/0.13 nM/0.024 nM/0.06 nM and 0.18 nM/0.3 nM for p110α/β/δ/γ, mTORC1/2, respectively. Omipalisib has anti-cancer activity[2][3]. Research Area：Cancer Targets：Autophagy|mTOR|PI3K Related Screening Libraries:Clinical Compound […]

For research use only. We do not sell to patients. HDAC-IN-37 Biological Activity：HDAC-IN-37 is a potent HDAC inhibitor with IC50s of 0.0551 μM, 1.24 μM, 0.948 μM and 34.2 μM for HDAC1, HDAC3, HDAC8 and HDAC6, respectively. HDAC-IN-37 induces histone acetylation in a slow-off manner. HDAC-IN-37 prevents cell transition from G1 phase to S phase […]

For research use only. We do not sell to patients. Disitertide TFA Biological Activity：Disitertide (P144) TFA is a peptidic transforming growth factor-beta 1 (TGF-β1) inhibitor specifically designed to block the interaction with its receptor. Disitertide TFA is also a PI3K inhibitor and an apoptosis inducer[2][3][4][5]. Research Area：Cancer Targets：TGF-beta/Smad|Apoptosis|PI3K Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;Umbralisib hydrochloride;BJE6-106;Dinaciclib;Ecteinascidin […]

For research use only. We do not sell to patients. Prexasertib dimesylate CAS No. : 1234015-58-7 Biological Activity：Prexasertib dimesylate (LY2606368 dimesylate) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of

For research use only. We do not sell to patients. Topotecan-d6 CAS No. : 1044904-10-0 Biological Activity：Topotecan-d6 is the deuterium labeled Topotecan. Topotecan (SKF 104864A; NSC 609669) is a Topoisomerase I inhibitor. The IC50 values of Topotecan at 24 h are 2.73±0.25 μM of U251 cells, 2.95±0.23 μM of U87 cells, 5.46±0.41 μM of GSCs-U251 […]

For research use only. We do not sell to patients. Licofelone-d4 CAS No. : 1189427-04-0 Biological Activity：Licofelone-d4 (ML-3000-d4) is the deuterium labeled Licofelone. Licofelone (ML-3000) is a dual COX/5-lipoxygenase (5-LOX) inhibitor (IC50=0.21/0.18 μM, respectively) for the treatment of osteoarthritis. Licofelone exerts anti-inflammatory and anti-proliferative effects. Licofelone induces apoptosis, and decreases the production of proinflammatory leukotrienes […]

For research use only. We do not sell to patients. Irigenin CAS No. : 548-76-5 Biological Activity：Irigenin is a is a lead compound, and mediates its anti-metastatic effect by specifically and selectively blocking α9β1 and α4β1 integrins binding sites on C-C loop of Extra Domain A (EDA). Irigenin shows anti-cancer properties. It sensitizes TRAIL-induced apoptosis […]