Tag: Inhibitor|Inducer

For research use only. We do not sell to patients. Rutin hydrate CAS No. : 207671-50-9 Biological Activity：Rutin (Rutoside) hydrate is a flavonoid found in many plants and shows a wide range of biological activities including anti-inflammatory, antidiabetic, antioxidant, neuroprotective, nephroprotective, hepatoprotective and reducing Aβ oligomer activities. Rutin hydrate can cross the blood brain barrier. […]

For research use only. We do not sell to patients. PARP1/2/TNKS1/2-IN-1 Biological Activity：PARP1/2/TNKS1/2-IN-1 (Compound I-9) is a dual PARP-1, PARP-2, TNKS1 and TNKS2 inhibitor with IC50 values of 0.25 nM, 1.2 nM, 13.5 nM and 4.15 nM against PARP-1, PARP-2, TNKS1 and TNKS2, respectively. PARP1/2/TNKS1/2-IN-1 exhibits favorable synergistic antitumor efficacy and induces apoptosis. Research Area：Cancer […]

For research use only. We do not sell to patients. c-Met/HDAC-IN-3 CAS No. : 2439175-23-0 Biological Activity：c-Met/HDAC-IN-3 (Compound 15f) is a dual c-Met and HDAC inhibitor with IC50 values of 12.50 nM and 26.97 nM against c-Met and HDAC1, respectively. c-Met/HDAC-IN-3 induces apoptosis and cause cell cycle arrest in G2/M phase. Research Area：Cancer Targets：HDAC|c-Met/HGFR|Apoptosis Related […]

For research use only. We do not sell to patients. KTX-582 CAS No. : 2573298-13-0 Biological Activity：KTX-582 is a potent IRAK4 degrader with DC50 values of 4 nM and 5 nM for IRAK4 and Ikaros, respectively. KTX-582 can induce apoptosis in MYD88MT DLBCL, and is efficient to induce in vivo tumor regressions in lymphoma model[2][3]. […]

For research use only. We do not sell to patients. PND-1186 CAS No. : 1061353-68-1 Biological Activity：PND-1186 (VS-4718) is a potent, highly-specific and reversible inhibitor of FAK with an IC50 of 1.5 nM. PND-1186 selectively promotes tumor cell apoptosis. Research Area：Cancer Targets：FAK|Apoptosis Related Screening Libraries:Clinical Compound Library Plus;Bioactive Compound Library Plus;Apoptosis Compound Library;Kinase Inhibitor Library;Protein […]

For research use only. We do not sell to patients. Momelotinib CAS No. : 1056634-68-4 Biological Activity：Momelotinib (CYT387) is an ATP-competitive inhibitor of JAK1/JAK2 with IC50a of 11 nM and 18 nM,respectively. CYT387 shows much less activity against JAK3. Research Area：Cancer Targets：JAK|Autophagy|Apoptosis Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Apoptosis […]

For research use only. We do not sell to patients. KS100 CAS No. : 2408477-54-1 Biological Activity：KS100 is a potent ALDH inhibitor with IC50s of 230, 1542, 193 nM for ALDH1A1, ALDH2, and ALDH3A1, respectively. KS100 shows antiproliferative and anticancer effects with low low toxic. KS100 significantly increases ROS activity, lipid peroxidation and toxic aldehyde […]

For research use only. We do not sell to patients. Irinotecan hydrochloride trihydrate CAS No. : 136572-09-3 Biological Activity：Irinotecan hydrochloride trihydrate ((+)-Irinotecan hydrochloride trihydrate) is a topoisomerase I inhibitor with antitumor activity. Research Area：Cancer Targets：Topoisomerase|Autophagy Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini; Bioactive Compound Library Plus;Cell Cycle/DNA Damage Compound […]

For research use only. We do not sell to patients. Tubulysin A CAS No. : 205304-86-5 Biological Activity：Tubulysin A(TubA) is a myxobacterial product that can function as an antiangiogenic agent in many in vitro assays; anti-microtubule, anti-mitotic, an apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative. IC50 value: Target: microtubule Tubulysin A is a novel antibiotic, which […]

For research use only. We do not sell to patients. Capecitabine CAS No. : 154361-50-9 Biological Activity：Capecitabine is an oral prodrug that is converted to its active metabolite, 5-FU, by thymidine phosphorylase. Research Area：Cancer Targets：Nucleoside Antimetabolite/Analog|DNA/RNA Synthesis|Apoptosis Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Apoptosis Compound Library;Cell […]