Tag: Inhibitor|Inducer

For research use only. We do not sell to patients. AES-350 CAS No. : 847249-57-4 Biological Activity：AES-350 is a potent and orally active HDAC6 inhibitor with an IC50 and a Ki of 0.0244 μM and 0.035 μM, respectively. AES-350 is also against HDAC3, HDAC8 in an enzymatic activity assay with IC50 values of 0.187 μM […]

For research use only. We do not sell to patients. Lonafarnib CAS No. : 193275-84-2 Biological Activity：Lonafarnib (Sch66336) is a potent and orally active farnesyl transferase (FTase) inhibitor. Lonafarnib inhibits the activities of H-ras, K-ras and N-ras with IC50 values of 1.9 nM, 5.2 nM and 2.8 nM, respectively. Lonafarnib also has anti-hepatitis delta virus […]

For research use only. We do not sell to patients. Gambogic Acid CAS No. : 2752-65-0 Biological Activity：Gambogic Acid (Beta-Guttiferrin) is derived from the gamboges resin of the tree Garcinia hanburyi. Gambogic Acid (Beta-Guttiferrin) inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50s of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM […]

For research use only. We do not sell to patients. Griseofulvin CAS No. : 126-07-8 Biological Activity：Griseofulvin(Gris-PEG; Grifulvin) is a spirocyclic fungal natural product used in treatment of fungal dermatophytes; Antifungal drug. Research Area：Infection|Cancer Targets：Fungal|Antibiotic|Endogenous Metabolite|Apoptosis Related Screening Libraries:Natural Product Library Plus;Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Anti-Infection […]

For research use only. We do not sell to patients. PDGFR-IN-1 CAS No. : 2644673-07-2 Biological Activity：PDGFR-IN-1 (compound 7m) is a potent and orally active PDGFR (platelet-derived growth factor receptor) inhibitor, with IC50 values of 2.4 and 0.9 nM for PDGFRα and PDGFRβ, respectively. PDGFR-IN-1 displays robust antitumor effects and low toxicity, and can be […]

For research use only. We do not sell to patients. GSK-843 CAS No. : 1601496-05-2 Biological Activity：GSK-843 (GSK’843) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC50 of 8.6 nM, and inhibits kinase activity with an IC50 of 6.5 nM. GSK-843 can be used for the […]

For research use only. We do not sell to patients. Salvigenin CAS No. : 19103-54-9 Biological Activity：Salvigenin is a natural polyphenolic compound, with neuroprotective effect. Salvigenin has antitumor cytotoxic and immunomodulatory properties. Salvigenin inhibits H2O2-induced cell apoptosis[2]. Research Area：Cancer|Inflammation/Immunology|Neurological Disease Targets：Autophagy|ROS Kinase|Apoptosis Related Screening Libraries:Natural Product Library Plus;Bioactive Compound Library Plus;Apoptosis Compound Library;Immunology/Inflammation Compound Library;Kinase […]

For research use only. We do not sell to patients. Icariside D2 CAS No. : 38954-02-8 Biological Activity：Icariside D2, isolated from Annona glabra fruit, inhibits angiotensin-converting enzyme. Icariside D2 shows significant cytotoxic activity on the HL-60 cell line with the IC50 value of 9.0 ± 1.0 μM. Icariside D2 induces apoptosis [2]. Research Area：Cancer|Infection|Inflammation/Immunology Targets：Angiotensin-converting […]

For research use only. We do not sell to patients. Gartanin CAS No. : 33390-42-0 Biological Activity：Gartanin is a natural xanthone of mangosteen, with antioxidant, anti-inflammatory, antifungal, neuroprotective and antineoplastic properties. Gartanin induces cell cycle arrest and autophagy and suppresses migration in human glioma cells[2]. Research Area：Cancer Targets：Fungal|Autophagy Related Screening Libraries:Natural Product Library Plus;Bioactive Compound […]

For research use only. We do not sell to patients. TMI-1 CAS No. : 287403-39-8 Biological Activity：TMI-1 is a potent inhibitor of disintegrin metalloenzyme 17 (ADAM17) and other MMPs. TMI-1 inhibits LPS-induced TNF-α secretion in human primary monocytes, and human whole blood. TMI-1 selectively induces caspase-dependent apoptosis in triple negative (TN) and ERBB2-overexpressing breast tumor […]