Tag: Inhibitor|Inducer

For research use only. We do not sell to patients. S65487 sulfate CAS No. : 2416937-01-2 Biological Activity：S65487 (VOB560) sulfate, a potent and selective Bcl-2 inhibitor, is a prodrug of S55746. S65487 sulfate is also active on BCL-2 mutations, such as G101V and D103Y. S65487 sulfate has poor affinity with MCL-1, BFL-1 and BCL-XL. S65487 […]

For research use only. We do not sell to patients. Lactoferrin (17-41) CAS No. : 146897-68-9 Biological Activity：Lactoferrin 17-41 (Lactoferricin B), a peptide corresponding to residues 17-41 of bovine lactoferrin, has antimicrobial activity against a wide range of microorganisms, including Gram-positive and Gramnegative bacteria, viruses, protozoa, and fungi. Lactoferrin 17-41 has antitumor activities[2]. Research Area：Cancer|Infection […]

For research use only. We do not sell to patients. Copanlisib dihydrochloride CAS No. : 1402152-13-9 Biological Activity：Copanlisib dihydrochloride (BAY 80-6946 dihydrochloride) is a potent, selective and ATP-competitive pan-class I PI3K inhibitor, with IC50s of 0.5 nM, 0.7 nM, 3.7 nM and 6.4 nM for PI3Kα, PI3Kδ, PI3Kβ and PI3Kγ, respectively. Copanlisib dihydrochloride has more […]

For research use only. We do not sell to patients. Docetaxel Trihydrate CAS No. : 148408-66-6 Biological Activity：Docetaxel Trihydrate (RP-56976 Trihydrate) is an antineoplastic agent and inhibits microtubule depolymerization with an IC50 value of 0.2 μM. Docetaxel Trihydrate is a semisynthetic analog of taxol and attenuates the effects of bcl-2 and bcl-xL gene expression. Docetaxel Trihydrate arrests the cell cycle […]

For research use only. We do not sell to patients. TAS6417 CAS No. : 1661854-97-2 Biological Activity：TAS6417 (CLN-081) is a highly effective, orally active and pan-mutation-selective EGFR tyrosine kinase inhibitor with a unique scaffold fitting into the ATP-binding site of the EGFR hinge region, with IC50 values ranging from 1.1-8.0 nM[2]. Research Area：Cancer Targets：EGFR|Apoptosis Related […]

For research use only. We do not sell to patients. Nimbolide CAS No. : 25990-37-8 Biological Activity：Nimbolide is a triterpene derived from the leaves and flowers of neem (Azadirachta indica). Nimbolide induces apoptosis through inactivation of NF-κB. Nimbolide inhibits CDK4/CDK6 kinase activity. Nimbolide suppresses the NF-κB, Wnt, PI3K-Akt, MAPK and JAK-STAT signaling pathways. Research Area：Cancer […]

For research use only. We do not sell to patients. Ixabepilone CAS No. : 219989-84-1 Biological Activity：Ixabepilone (BMS-247550) is an orally bioavailable microtubule inhibitor, which binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arrests cells in the G2-M phase of the cell cycle and induces tumor cell apoptosis. Research Area：Cancer Targets：Microtubule/Tubulin|Bacterial|Apoptosis Related Screening Libraries:Drug […]

For research use only. We do not sell to patients. Antimycin A3 CAS No. : 522-70-3 Biological Activity：Antimycin A3, an antibiotic isolated from a number of Streptomyces species, shows antifungal activities. Antimycin A3 is a potent inhibitor of respiration. Antimycin A3 inhibits the electron transfer activity of ubiquinol-cytochrome c oxidoreductase. Antimycin A3 inhibits ATP-citrate lyase […]

For research use only. We do not sell to patients. Cobimetinib CAS No. : 934660-93-2 Biological Activity：Cobimetinib (GDC-0973, RG7420) is a potent, selective and oral MEK1 inhibitor with an IC50 of 4.2 nM for MEK1. Research Area：Cancer Targets：MEK|Apoptosis Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Apoptosis Compound […]

For research use only. We do not sell to patients. LRRK2-IN-1 CAS No. : 1234480-84-2 Biological Activity：LRRK2-IN-1 is a potent and selective LRRK2 inhibitor with IC50 of 6 nM and 13 nM for LRRK2 (G2019S) and LRRK2 (WT), respectively. Research Area：Neurological Disease|Cancer Targets：Apoptosis|LRRK2 Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Kinase Inhibitor Library;Anti-Cancer Compound Library;Autophagy Compound Library;Anti-Parkinson’s Disease Compound […]