Tag: Inhibitor|Inducer

For research use only. We do not sell to patients. Felodipine-d3 CAS No. : 1219795-30-8 Biological Activity：Felodipine-d3 is the deuterium labeled Felodipine. Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. […]

For research use only. We do not sell to patients. Antitumor agent-45 CAS No. : 2581082-74-6 Biological Activity：Antitumor agent-45 (Compound 21) could induce and stimulate A549 cells apoptosis in G0/G1 and G2/M phase. Antitumor agent-45 (Compound 21) inhibits c-Met expression to regulate the growth of tumor cells. Research Area：Cancer Targets：c-Met/HGFR|Apoptosis Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic […]

For research use only. We do not sell to patients. Dihydroeponemycin CAS No. : 126463-64-7 Biological Activity：Dihydroeponemycin, an analogue of the antitumor and antiangiogenic natural product eponemycin, selectively targets the 20S proteasome. Dihydroeponemycin covalently modifies a subset of catalytic proteasomal subunits, binding preferentially to the IFN-gamma-inducible subunits LMP2 and LMP7. Dihydroeponemycin-mediated proteasome inhibition induces a […]

For research use only. We do not sell to patients. Capmatinib hydrochloride CAS No. : 1029714-89-3 Biological Activity：Capmatinib (INC280; INCB28060) hydrochloride is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor (IC50=0.13 nM). Capmatinib hydrochloride can inhibit phosphorylation of c-MET as well as c-MET pathway downstream effectors such as ERK1/2, AKT, FAK, GAB1, […]

For research use only. We do not sell to patients. USP7-IN-9 Biological Activity：USP7-IN-9 is a highly potent ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 value of 40.8 nM. USP7-IN-9 can induce apoptosis and arrest cell progression at G0/G1 and S phases in RS4; 11 cells. USP7-IN-9 reduces the protein levels of oncoproteins MDM2 and […]

For research use only. We do not sell to patients. HDAC-IN-48 Biological Activity：HDAC-IN-48 is a potent HDAC inhibitor. HDAC-IN-48 is a hybrid molecule with great cytotoxic profile (GI50~20 nM). HDAC-IN-48 consists of harmacophores of SAHA and CETZOLE molecules. HDAC-IN-48 induces ferroptosis and inhibits HDAC proteins. Research Area：Cancer Targets：Ferroptosis|HDAC Related Small Molecules:CIL56;DB0614;Ciclopirox-d11;Ciclopirox olamine;Curcumin;Pivanex;Crotonoside;MPT0B390;RSC133;HDAC1/6-IN-1;HDAC/HSP90-IN-4;JPS014;HDAC-IN-4;(-)-Epicatechin;HDAC-IN-27;Eugenol-d3;1-Alaninechlamydocin;SKLB-23bb;Tacedinaline;Artemisinin-d3;MMRi62;HPOB;HDAC-IN-28 Trending products：Recombinant Proteins  […]

For research use only. We do not sell to patients. Metronidazole CAS No. : 443-48-1 Biological Activity：Metronidazole is an orally active nitroimidazole antibiotic. Metronidazole can cross blood brain barrier. Metronidazole can be used for the research of anaerobic infections[2][3][4]. Research Area：Cancer|Infection|Inflammation/Immunology Targets：Parasite|Bacterial|Antibiotic|Apoptosis Related Screening Libraries:Natural Product Library Plus;Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved […]

For research use only. We do not sell to patients. [8]-Shogaol CAS No. : 36700-45-5 Biological Activity：[8]-Shogaol, one of the pungent phenolic compounds in ginger, exhibits anti-platelet activity (IC50=5 μM) and inhibits COX-2 (IC50=17.5 μM). [8]-Shogaol induces apoptosis in human leukemia cells[2][3][4]. Research Area：Cancer Targets：Apoptosis|COX Related Screening Libraries:Natural Product Library Plus;Bioactive Compound Library Plus;Apoptosis Compound […]

For research use only. We do not sell to patients. Mepazine CAS No. : 60-89-9 Biological Activity：Mepazine (Pecazine) is a potent and selective MALT1 protease inhibitor with IC50s of 0.83 and 0.42 μM for GSTMALT1 full length and GSTMALT1 325-760, respectively. Mepazine affects viability of ABC-DLBCL cells by enhancing apoptosis. Research Area：Cancer Targets：MALT1|Apoptosis Related Screening […]

For research use only. We do not sell to patients. CCT241161 CAS No. : 1163719-91-2 Biological Activity：CCT241161 is an orally active pan-RAF inhibitor with IC50s of 3, 6, 10, 15 and 30 nM for LCK, CRAF, SRC, V600E-BRAF and BRAF, respectively. CCT241161 shows good activity to in BRAF and NRAS mutant melanomas. CCT241161 also exhibits […]